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December 03, 2019; 93 (23) ArticleOpen Access

Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults

A 10-year cohort

Bang Zheng, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Mi Zhou, Ling Yang, Yiping Chen, Xiaojun Li, Ju Zou, Feng Ning, Junshi Chen, Zhengming Chen, Liming Li, on behalf of the China Kadoorie Biobank Collaborative Group
First published November 6, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008581
Bang Zheng
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Canqing Yu
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Jun Lv
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Yu Guo
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Zheng Bian
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Mi Zhou
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Ling Yang
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Yiping Chen
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Xiaojun Li
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Ju Zou
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Feng Ning
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Junshi Chen
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Zhengming Chen
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Liming Li
From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
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Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults
A 10-year cohort
Bang Zheng, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Mi Zhou, Ling Yang, Yiping Chen, Xiaojun Li, Ju Zou, Feng Ning, Junshi Chen, Zhengming Chen, Liming Li, on behalf of the China Kadoorie Biobank Collaborative Group
Neurology Dec 2019, 93 (23) e2110-e2120; DOI: 10.1212/WNL.0000000000008581

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Article Information

vol. 93 no. 23 e2110-e2120
DOI: 
https://doi.org/10.1212/WNL.0000000000008581
PubMed: 
31694922

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 31, 2019
  • Accepted in final form July 5, 2019
  • First Published November 6, 2019.

Article Versions

  • Previous version (November 6, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Disclosures

    1. Bang Zheng, MD, MSc,
    2. Canqing Yu, PhD,
    3. Jun Lv, PhD,
    4. Yu Guo, MSc,
    5. Zheng Bian, MSc,
    6. Mi Zhou, BSc,
    7. Ling Yang, PhD,
    8. Yiping Chen, DPhil,
    9. Xiaojun Li, BSc,
    10. Ju Zou, BSc,
    11. Feng Ning, PhD,
    12. Junshi Chen, MD,
    13. Zhengming Chen, DPhil,
    14. Liming Li, MD;
    15. on behalf of the China Kadoorie Biobank Collaborative Group
  1. Bang Zheng, MD, MSc,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Canqing Yu, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Jun Lv, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Yu Guo, MSc,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Zheng Bian, MSc,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Mi Zhou, BSc,
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Ling Yang, PhD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Yiping Chen, DPhil,
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Xiaojun Li, BSc,
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Ju Zou, BSc,
  20. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Feng Ning, PhD,
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  23. Junshi Chen, MD,
  24. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  25. Zhengming Chen, DPhil,
  26. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  27. Liming Li, MD;
  28. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  29. on behalf of the China Kadoorie Biobank Collaborative Group
  1. From the Department of Epidemiology and Biostatistics (B.Z., C.Y., J.L., M.Z., L.L.), School of Public Health, Peking University Health Science Center, Beijing, China; Neuroepidemiology and Aging Research Unit (B.Z.), School of Public Health, Imperial College London, UK; Chinese Academy of Medical Sciences (Y.G., Z.B., L.L.), Beijing; Clinical Trial Service Unit & Epidemiological Studies Unit (L.Y., Y.C., Z.C.), Nuffield Department of Population Health, University of Oxford, UK; Jili Community Health Service (X.L., J.Z.), Liuyang, Hunan; Qingdao Center for Disease Control and Prevention (F.N.), Shandong; and China National Center for Food Safety Risk Assessment (J.C.), Beijing.
  1. Correspondence
    Dr. L. Li lmlee{at}vip.163.com or Dr. Yu yucanqing{at}pku.edu.cn
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