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December 10, 2019; 93 (24) ArticleOpen Access

Migraine progression in subgroups of migraine based on comorbidities

Results of the CaMEO Study

Richard B. Lipton, Kristina M. Fanning, Dawn C. Buse, Vincent T. Martin, Lee B. Hohaia, Aubrey Manack Adams, Michael L. Reed, Peter J. Goadsby
First published November 5, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008589
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Article Information

vol. 93 no. 24 e2224-e2236
DOI: 
https://doi.org/10.1212/WNL.0000000000008589
PubMed: 
31690685
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 10, 2019
  • Accepted in final form June 26, 2019
  • First Published November 5, 2019.

Article Versions

Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Richard B. Lipton, MD,
    2. Kristina M. Fanning, PhD,
    3. Dawn C. Buse, PhD,
    4. Vincent T. Martin, MD,
    5. Lee B. Hohaia, PharmD,
    6. Aubrey Manack Adams, PhD,
    7. Michael L. Reed, PhD and
    8. Peter J. Goadsby, MD
  1. Richard B. Lipton, MD,
    2. Scientific Advisory Boards:

    1. Allergan, e-Neura, Merck

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Serves as consultant, advisory board member, or has received honoraria from: American Academy of Neurology, Alder, Allergan, American Headache Society, Amgen, Autonomic Technologies, Avanir, Biohaven, Biovision, Boston Scientific, Dr. Reddy?s, Electrocore, Eli Lilly, eNeura Therapeutics, GlaxoSmithKline, Merck, Pernix, Pfizer, Supernus, Teva, Trigemina, Vector, Vedanta

    Editorial Boards:

    1. Neurology, Editorial Board, 2017-

    Patents:

    1. NONE

    Publishing Royalties:

    1. Wolff's Headache, 8th Edition, Oxford University Press; Informa

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Serves as consultant, advisory board member, or has received honoraria from: American Academy of Neurology, Alder, Allergan, American Headache Society, Amgen, Autonomic Technologies, Avanir, Biohaven, Biovision, Boston Scientific, Dr. Reddy?s, Electrocore, Eli Lilly, eNeura Therapeutics, GlaxoSmithKline, Merck, Pernix, Pfizer, Supernus, Teva, Trigemina, Vector, Vedanta

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Vedanta Research Migraine epidemiology and Progression June 2010 - present Boston Scientific Occipital Nerve Stimulation in Migraine March 2013 - present ElectroCore Vagal Nerve Stimulation for Migraine and Cluster May 2013 Novartis Sleep and Migraine September 2012 - present Allergan Botox in Migraine April 2012 - present Allergan Chronic Migraine Epidemiology and Outcome Study January 2012 - present

    Research Support, Government Entities:

    1. NIH/NIA 2P01 AG003949 (PI: R. Lipton) 9/1/16-5/31/21 Einstein Aging Study Sachdev, P. (PI) (COSMIC) 09/15/17 – 06/30/22 1RF1AG057531-01 Site PI: Lipton R DeCarli, C. (PI) 7/15/17 – 6/30/22 RF1AG054548 Role: Co-Investigator 1R01AG048642 (Gonzalez) 9/1/2015 - 4/30/20 Role: Co-Investigator 1R01AG048642 (Gonzalez) 7/15/18-6/30/19 Role: Co-Investigator R56 AG057548 Verghese (PI) 9/30/17-8/31/19 Role: Co-Investigator K23 NS107643 Liberman (PI) 7/1/18-6/30/23 No salary support Role: Mentor K23 AG049466 Pavlovic (PI) 9/30/16-5/31/21 No salary support Role: Mentor K23 NS096107 Seng (PI) 4/16/16-3/31/21 No salary support Role: Mentor

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. S & L Marx Foundation Alzheimer's Research Czap Foundation Alzheimer's Research

    Stock/Stock Options/Board of Directors Compensation:

    1. eNeura Pharma; Biohaven Inc.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Wolff’s Headache 7th and 8th Edition, Oxford Press University, 2009, Wiley and Informa.

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Kristina M. Fanning, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Kristina M. Fanning is an employee of Vedanta Research, which has received support funded by Allergan, Inc., Amgen, CoLucid, Dr. Reddy’s Laboratories, Endo Pharmaceuticals, GlaxoSmithKline, MAP Pharmaceuticals, Merck & Co., Inc., NuPathe, Novartis, Ortho-McNeil, and Zogenix via grants to the National Headache Foundation.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Dawn C. Buse, PhD,
    4. Scientific Advisory Boards:

    1. (1) Allergan, Inc., Amgen, Eli Lilly, Biohaven Pharmaceuticals, Promeius.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1. Current Pain and Headache Reports, section editor, 2012-current 2. Journal of Headache and Pain, editorial board, 2012- current 3. Pain Pathways Magazine, advisory board, 2014-current 4. Pain Medicine News, advisory board, 2014-current

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Allergan, Inc., Amgen, Avanir, Eli Lilly, Biohaven Pharmaceuticals.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Allergan, Inc., Amgen, Lilly, Promeius.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Headache Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Vincent T. Martin, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Allergan, Eli Lilly, Teva, Amgen, Alder, Biohaven,Promius

    Editorial Boards:

    1. Headache, Associate Editor

    Patents:

    1. Weather models for predicting heqadache

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. University of Cincinnati, Professor of Medicine, 29 yrs UC Health, Physician, 29 yrs

    Consultancies:

    1. Eli Lilly,Biohaven, Teva,Allergan, Amgen

    Speakers' Bureaus:

    1. Eli Lilly, Teva, Allergan, Amgen

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Allergan- Chronic Migraine study for Atogepant

    Research Support, Government Entities:

    1. PCORI Grant- MOTS Trial

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Lee B. Hohaia, PharmD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. CHC Group, LLC; Senior Medical Writer; 3 years

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. An employee of CHC Group, LLC, an ICON plc company, which has received funding form Allergan for manuscript development

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Aubrey Manack Adams, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Allergan, VP, Medical Affairs, 15 years

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I am an employee of Allergan

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. I am an employee of Allergan

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. Allergan, 15 years

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Michael L. Reed, PhD and
    8. Scientific Advisory Boards:

    1. (1) Allergan Inc. CaMEO Study Advisory Committee (2) Eli Lilly and Company, OVERCOME Study Advisory Board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Allergan Inc. (2) Promius Pharmaceuticals (3) Eli Lilly and Company (4) Amgen

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) National Headache Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Peter J. Goadsby, MD
    9. Scientific Advisory Boards:

    1. I have consulted for the following commercial entities Alder Bio Allergan Amgen Autonomic Technologies Inc Dr Reddy's Laboratories Eli-Lilly Electrocore LLC eNeura Inc Impel Neuropharma MundiPharma Novartis Teva Pharmaceuticals Trigemina WL Gore

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Up-to-Date Massachusetts Medical Society

    Patents:

    1. NONE

    Publishing Royalties:

    1. Lance JW, Goadsby PJ. Mechanism and Management of Headache. (7th ed.) New York: Elsevier, 2005

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Amgen, Eli-Lilly

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Trigemina, Inc, stock options

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. MedicoLegal work

  1. From the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
  1. Correspondence
    Dr. Lipton Richard.Lipton{at}einstein.yu.edu

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