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August 06, 2019; 93 (6) Article

Motor cortex inhibition and modulation in children with ADHD

Donald L. Gilbert, David A. Huddleston, Steve W. Wu, Ernest V. Pedapati, Paul S. Horn, Kathryn Hirabayashi, Deanna Crocetti, Eric M. Wassermann, Stewart H. Mostofsky
First published July 17, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007899
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Article Information

vol. 93 no. 6 e599-e610
DOI: 
https://doi.org/10.1212/WNL.0000000000007899
PubMed: 
31315973
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 4, 2018
  • Accepted in final form March 20, 2019
  • First Published July 17, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Donald L. Gilbert, MD, MS,
    2. David A. Huddleston, BA,
    3. Steve W. Wu, MD,
    4. Ernest V. Pedapati, MD, MS,
    5. Paul S. Horn, PhD,
    6. Kathryn Hirabayashi,
    7. Deanna Crocetti,
    8. Eric M. Wassermann, MD and
    9. Stewart H. Mostofsky, MD
  1. Donald L. Gilbert, MD, MS,
    2. Scientific Advisory Boards:

    1. Tourette Association of America Scientific Advisory Board - non-profit

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Tourette Association of America / Centers for Disease Control and Prevention: Honoraria, travel expenses for educational talks to physicians and affected patients and families. American Academy of Pediatrics - travel expenses, honorarium for teaching. Child Neurology Society for service on executive board.

    Editorial Boards:

    1. Associate editor for Pediatric Neurology.

    Patents:

    1. NONE

    Publishing Royalties:

    1. Royalties for: Movement Disorders in Childhood, 2nd edition. Author(s): Harvey S. Singer, MD, Jonathan W. Mink, MD, PhD, Donald L. Gilbert, MD, and Joseph Jankovic, MD Elsevier 2015. Pediatric Brain Stimulation. Editors: Adam Kirton, Donald L Gilbert. Elsevier 2016. Up to Date - Wolters Kluwer.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Psyadon Pharmaceuticals, site investigator. EryDel Pharmaceuticals. Clinical trials site investigator. Research work only, plus travel to investigator start up meetings.

    Research Support, Government Entities:

    1. R01 NS096207 2016-2021 Co-PI; R01 MH095014 2012-2018 Co- PI; R01 NS085023 2014-2019 Researcher;

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Tourette Association of America, research grant.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Expert Testimony: the U.S. National Vaccine Injury Compensation Program, through the Department of Health and Human Services

  2. David A. Huddleston, BA,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Steve W. Wu, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Medtronic

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Site PI for multi-center clinical trial for Ataxia Telangiectasis (EryDel, S.p.A.).

    Research Support, Government Entities:

    1. (1) NIH-NINDS, R01NS096207, sub-investigator, year 3 of 5, (2) NIH-NIMH, R01MH115962, sub-investigator, year 1 of 5

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Tourette Association of America

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Ernest V. Pedapati, MD, MS,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Textbook. Contemporary Psychodynamic Psychotherapy for Children and Adolescents: Integrating Intersubjectivity and Neuroscience. Springer.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1. Commercial (No relationship or conflict with the current manuscript) Proctor & Gamble < 4 hours a month (consumer, non- pharmaceutical consulting) Eccerine Systems < 10 hours a month (non-pharmaceutical, medical device consulting) Autism Speaks < 5 hours month (contract parent education textbook)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. K23MH112936 (Pedapati, PI) 5 year career development award

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Academy of Child and Adolescent Psychiatry Junior Investigator Award

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Paul S. Horn, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Reference Intervals: A User?s Guide, American Association of Clinical Chemistry Press, 2005.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NINDS, R01 NS103824-01A1, Role: Biostatistician, July 1, 2018 ? June 30, 2023. NIH/NINDS, R01NS096207, Role: Biostatistician, April 15, 2016 ? March 31, 2021. NIH, U54 HD082008, Role: Biostatistician, June 1, 2016 ? May 31, 2019.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Autism Speaks, SPR 200682 The John Merck Fund

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Kathryn Hirabayashi,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Deanna Crocetti,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Eric M. Wassermann, MD and
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neuromodulation, section editor 2014-present Cortex, associate editor, 2018-present

    Patents:

    1. Co-inventor: US Patent # 9,861,287; Hematoma detector. Handheld, near-infrared device for detecting intracranial fluid collections

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS intramural support, all years ?Restoring critical connections after brain injury with repetitive transcranial magnetic stimulation.? Pilot project, Center for Neuroscience and Restorative Medicine CNRM-70-3904 Stock/Stock Options, Medical Equipment & Materials: Currently held ALXN ALEXION PHARMS INC BAYRY BAYER AG SP ADR BIIB BIOGEN INC CELG CELGENE CORP COM CVS CVS HEALTH CORP XRAY DENTSPLY SIRONA INC ECL ECOLAB INC PFE PFIZER INC PG PROCTER & GAMBLE CO REGN REGENERON PHARMACTCLS RHHBY ROCHE HLDG LTD SPN ADR GENERAL ELEC CAP CORP SER NOTZ

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Stewart H. Mostofsky, MD
    10. Scientific Advisory Boards:

    1. Served on a scientific advisory board assembled by Bristol-Myers Squibb to examine preliminary studies of efficacy of Abilify in children with autism spectrum disorders

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaking Honorarium from National Academy of Neuropsychology, 2008 Speaking Honorarium from University of Maryland, 2009 Speaking Honorarium from Maryland Psychiatric Society 2009 Speaking Honorarium, Learning & The Brain 2010 Speaking Honorarium from Philips 2010 Speaking Honorarium from National Academy of Neuropsychology, 2011 Speaking Honorarium, MIND Institute, 2014 Speaking Honorarium, University of Connecticut, 2014 Speaking Honorarium, University of Florida, 2014 Speaking Honorarium, NYU, 2015 Speaking Honorarium, University of Manchester, 2015

    Editorial Boards:

    1. Editorial Board Member, Neurocase, since 2003.

    Patents:

    1. Pending: U.S. Patent Application No. 15/310,637

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Served on a scientific advisory board assembled by Bristol-Myers Squibb to examine preliminary studies of efficacy of Abilify in children with autism spectrum disorders Clarion Healthcare Consulting, LLC, 2019

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 5 K23 MH101322-05 (PI: Rosch) 09/13/13 ? 08/31/19 n.c.e. NIH / NIMH $145,688 *0% (Mentor) Role: Mentor 5 R01 MH085328-13 (PI: Mostofsky) 07/01/15 ? 06/30/20 NIH / NIMH $855,800 20% (2.40 calendar) Role: Principal Investigator 3 R01 MH085328-13S1 (PI: Mostofsky) 07/17/18 ? 06/30/19 NIH / NIMH $159,346 *5% (0.60 calendar) Role: Principal Investigator 5 K23 MH107734-03 (PI: Seymour) 09/01/15 ? 06/30/20 NIH / NIMH $71,758 *0% (Mentor) Role: Mentor (PI of subcontract) 5 R01 MH106564-03 (PI: Edden) 01/18/16 ? 11/30/20 NIH / NIMH $316,514 10% (1.20 calendar) Role: Co-Investigator (PI of subcontract) 5 R01 NS096207-03 (MPI: Mostofsky & Gilbert) 04/15/16 ? 03/31/21 NIH / NINDS $570,832 25% (3.00 calendar) Role: Principal Investigator 5 K01 MH109766-03 (PI: Nebel) 05/13/16 ? 03/31/21 NIH / NIMH $150,675 *0% (Mentor) Role: Mentor 5 R01 ES026961 (PI: Volk) 09/30/16 ? 08/31/21 NIH / NIEHS $25,822 7.50% (0.90 calendar) Role: Co-Investigator (PI of subcontract) 5 R01 EB020062-03 (MPI: Miller, Mostofsky, Paulsen, Wang) 09/30/16 - 07/31/20 NIH / NIBIB $70,136 2% (0.24 calendar) Role: Co-Investigator (PI of subcontract) 5 R01 MH113652-02 (PI: Ewen) 09/01/17 ? 07/31/22 NIH / NIMH $529,137 10% (1.20 calendar) Role: Co-Investigator 5 R01 HD090266-02 (PI: Suskauer) 02/13/18 ? 01/31/23 NIH / NICHD $727,272 5% (0.60 calendar) Role: Co-Investigator 4 R00 MH107719-03 (PI: Puts) 07/01/18 ? 06/30/19 NIH / NIMH $50,550 *5% (0.60 calendar) Role: Mentor # 1822581 (MPI: Venkataraman & Mostofsky) 10/01/18 ? 09/30/21 National Science Foundation $44,584 4.16% (0.50 calendar) Role: Co-Principal Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 23825 (PI: Seymour) 01/15/16 ? 01/14/20 n.c.e. Brain & Behavior Research Fdn $28,437 *0% (Mentor) Role: Mentor (PI of subcontract) 412720_GR412622-KKI (PI: Ullman) 10/01/17 ? 09/30/19 Tourette Syndrome Association $19,236 2% (0.24 calendar) Role: Co-Investigator (PI of subcontract)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. In 2007 I reviewed records from a legal case proceeding in the state of Florida. I did not serve as a witness in that case and did not prepare an affidavit.

  1. From the Division of Neurology (D.L.G., D.A.H., S.W.W., E.V.P., P.S.H.) and Department of Psychiatry (E.V.P.), Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH; Center for Neurodevelopmental and Imaging Research (K.H., D.C., S.H.M.), Kennedy Krieger Institute, Baltimore; Behavioral Neurology Unit (E.M.W.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda; and Departments of Neurology and Psychiatry (S.H.M.), Johns Hopkins University School of Medicine, Baltimore, MD.
  1. Correspondence
    Dr. Gilbert Donald.gilbert{at}cchmc.org
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