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August 27, 2019; 93 (9) ArticleOpen Access

Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

Frank J. Wolters, Hazel I. Zonneveld, Silvan Licher, Lotte G.M. Cremers, on behalf of the Heart Brain Connection Collaborative Research Group, M. Kamran Ikram, Peter J. Koudstaal, Meike W. Vernooij, M. Arfan Ikram
First published July 31, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008003
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  • Figure 1
    Figure 1 Hemoglobin in relation to structural connectivity and volume of white matter hyperintensities (WMH)

    (A, B) Hemoglobin in relation to structural connectivity and (C) volume of WMHs. Solid black lines represent the association of hemoglobin levels with mean diffusivity (A), fractional anisotropy (B), and volume of WMH (C). Dotted lines reflect the 95% confidence interval (CI). The inline figures show the values per quintile of hemoglobin, as compared to the middle (reference) quintile. Higher mean diffusivity and lower fractional anisotropy indicate worse structural connectivity.

  • Figure 2
    Figure 2 Hemoglobin and cerebral perfusion

    Cerebral perfusion per quintile of hemoglobin (A), and continuously, stratified by severity of white matter hyperintensities (WMHs) on MRI (B; the dashed lines represent the 95% confidence limits). CI = confidence interval.

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