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January 07, 2020; 94 (1) Article

NOTCH3 cysteine-altering variant is an important risk factor for stroke in the Taiwanese population

Yi-Chung Lee, Chih-Ping Chung, Ming-Hong Chang, Shuu-Jiun Wang, Yi-Chu Liao
First published December 2, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008700
Yi-Chung Lee
From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
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Chih-Ping Chung
From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
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Ming-Hong Chang
From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
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Shuu-Jiun Wang
From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
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Yi-Chu Liao
From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
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NOTCH3 cysteine-altering variant is an important risk factor for stroke in the Taiwanese population
Yi-Chung Lee, Chih-Ping Chung, Ming-Hong Chang, Shuu-Jiun Wang, Yi-Chu Liao
Neurology Jan 2020, 94 (1) e87-e96; DOI: 10.1212/WNL.0000000000008700

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Article Information

vol. 94 no. 1 e87-e96
DOI: 
https://doi.org/10.1212/WNL.0000000000008700
PubMed: 
31792094

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 17, 2019
  • Accepted in final form June 27, 2019
  • First Published December 2, 2019.

Article Versions

  • Previous version (December 2, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Yi-Chung Lee, MD, PhD,
    2. Chih-Ping Chung, MD, PhD,
    3. Ming-Hong Chang, MD,
    4. Shuu-Jiun Wang, MD, PhD and
    5. Yi-Chu Liao, MD, PhD
  1. Yi-Chung Lee, MD, PhD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) World Congress of Neurology 2017, speaker honoraria, USD$1000 (2)The Asian Oceanian Congress of Neurology 2018, speaker honoraria, USD$800

    Editorial Boards:
    1. (1) Acta Neurologica Taiwanica, Acting Editor, 2012 till now

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. (1) Ministry of Science and Technology, Taiwan, 105-2628-B-075 -002 - MY3, Principal investigator, 2016/8-2019/7 (2) Ministry of Science and Technology, Taiwan, 107-2314-B-075 -014 - MY3, Principle investigator, 2018/8-2021/7 (3)Ministry of Science and Technology, Taiwan, 108-2312-B-075 -001,Principle investigator, 2019/1-2019/12

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Taiwan Motor Neuron Disease Association

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Chih-Ping Chung, MD, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Ming-Hong Chang, MD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Shuu-Jiun Wang, MD, PhD and
  8. Scientific Advisory Boards:
    1. (1) Allergan (Commercial) (2) Eli Lilly (Commercial) (3) Daiichi-Sankyo (Commercial) (4) Norvastis Taiwan (Commercial)

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Pfizer Taiwan (Speaking honoraria, commercial) (2) Eli Lilly Taiwan (Speaking honoraria, commercial) (3) GSK Taiwan (Speaking honoraria, commercial)

    Editorial Boards:
    1. Editor, Journal of the Chinese Medical Association, 2005- Associate editor, Cephalalgia, 2009- Associate editor for headache, MedLink Neurology, 2009- Associate editor, Headache, 2013- Associate editor, Journal of Headache and Pain, 2012-

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. (1) Ministry of Science and Technology of Taiwan [MOST 107- 2321-B-010-001,MOST 106-2321-B-010-009-, MOST 106-2314-B- 010 -019 -MY2] (2) Ministry of Health and Welfare, Taiwan [MOHW 107-TDU-B- 211-123001, MOHW 108-TDU-B-211-133001] (2) Taipei-Veterans General Hospital [V108C-105, V107C-13] (3) Brain Research Center, National Yang-Ming University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. (1) Taiwan Headache Society

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Yi-Chu Liao, MD, PhD
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.
  1. Correspondence
    Dr. Liao ycliao5{at}vghtpe.gov.tw
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Cited By...

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Disputes & Debates: Rapid online correspondence

  • Reader response: NOTCH3 cysteine-altering variant is an important risk factor for stroke in the Taiwanese population
    • Xingshun Xu, Neurologist, Department of Neurology, the First Affiliated Hospital of Soochow University
    • Miao Sun, Genetic scientist, Institute of Fetology, the First Affiliated Hospital of Soochow University
    Submitted January 11, 2020
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