Notable from Our Podcast
The April 23, 2019, podcast interview highlighted a Neurology® Clinical Practice article on the Montreal Cognitive Assessment as a screening tool. For our What's Trending feature of the week, you'll hear an interview discussing serum neurofilament dynamics prediction of neurodegeneration and clinical progression in presymptomatic Alzheimer disease.
Author Tip
Neurology recently adopted the following policy in support of the movement to promote data transparency: Data not provided in a Neurology article because of space limitations must be made available in a trusted data repository or shared at the request of other investigators for purposes of replicating procedures and results. Neurology created a mechanism for editors and peer reviewers to review data deposited in the Dryad public repository at the time of manuscript submission. Authors will pay a nominal fee for depositing data in a public repository (waivers exist for submissions from authors based in countries classified by the World Bank as low- or middle-income economies).
From the AAN Press Room
Visit AAN.com/pressroom for the latest press releases
What comes first, beta-amyloid plaques or thinking and memory problems?
The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer's disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. “Our research was able to detect subtle thinking and memory differences in study participants and these participants had faster amyloid accumulation on brain scans over time, suggesting that amyloid may not necessarily come first in the Alzheimer's disease process,” said study author Kelsey R. Thomas, PhD, of the VA San Diego Healthcare System in San Diego. “Much of the research exploring possible treatments for Alzheimer's disease has focused on targeting amyloid. But based on our findings, perhaps that focus needs to shift to other possible targets.”
Thomas KR, Bangen KJ, Weigand AJ et al. Neurology 2019:94;e397–e406. doi.org/10.1212/WNL.0000000000008838
CME
Vegetarian diet and incidence of total, ischemic, and hemorrhagic stroke in 2 cohorts in Taiwan
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Posttraumatic vs nontraumatic headaches: A phenotypic analysis in a military population
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Most-Read Articles
As of October 2, 2019
Quantity and quality of mental activities and the risk of incident mild cognitive impairment
J. Krell-Roesch, J.A. Syrjanen, M. Vassilaki, et al. Neurology 2019;93:e548–e558. doi.org/10.1212/WNL.0000000000007897
Clinical Reasoning: A misdiagnosis of atypical trigeminal neuralgia
J.R. Duvall, C.E. Robertson. Neurology 2019;93:124–131. doi.org/10.1212/WNL.0000000000007790
Clinical Reasoning: A 47-year-old man with diffuse white matter disease and rapidly progressive dementia
D.G. Di Luca, J. Landman, M.R. Ortega, S.H. Gultekin, X. Sun. Neurology 2019;92:e2832–e2837. doi.org/10.1212/WNL.0000000000007655
SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies
C. Verducci, F. Hussain, E. Donner, et al. Neurology 2019;93:e227–e236. doi.org/10.1212/WNL.0000000000007778
How I learned to stop researching and live in the moment
B. Sadler, J.E. Sadler. Neurology 2019;92:1157–1158.
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