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March 17, 2020; 94 (11) ArticleOpen Access

Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men

Christian Benedict, Kaj Blennow, Henrik Zetterberg, Jonathan Cedernaes
First published January 8, 2020, DOI: https://doi.org/10.1212/WNL.0000000000008866
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Article Information

vol. 94 no. 11 e1181-e1189
DOI: 
https://doi.org/10.1212/WNL.0000000000008866
PubMed: 
31915189
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 20, 2019
  • Accepted in final form September 27, 2019
  • First Published January 8, 2020.

Article Versions

Copyright & Usage: 
© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Disclosures

    1. Christian Benedict, PhD,
    2. Kaj Blennow, MD, PhD,
    3. Henrik Zetterberg, MD, PhD and
    4. Jonathan Cedernaes, MD, PhD
  1. Christian Benedict, PhD,
    2. Scientific Advisory Boards:

    1. 2017-2019 Member of the Data Safety Management Monitoring Board for: A Phase II; Single Center, Randomized, DoubleBlind, Placebo-Controlled Study of the Safety and the Therapeutic Effectiveness of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s disease.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 2018-present: Associate Editor at Frontiers in Endocrinology

    Patents:

    1. NONE

    Publishing Royalties:

    1. I have written a popular-scientific book about the role of sleep on health and performance. This book has been published by the Swedish publisher Bonnier Fakta in November 2018. In September 2019, my book has been published in Germany (by the German publishing house Eden Books). Once a year, I receive royalty for sold books.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Kaj Blennow, MD, PhD,
    3. Scientific Advisory Boards:

    1. Dr Blennow has served as a consultant or at advisory boards for Alector, Alzheon, Biogen, CogRx, Lilly, Novartis and Roche Diagnostics

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Lundbeck, Roche Diagnostics

    Research Support, Government Entities:

    1. LUA/ALF project, Västra Götalandsregionen, Sweden (project # ALFGBG- 11019)

    Research Support, Academic Entities:

    1. Dr. Blennow holds the Torsten Söderberg professorship in Medicine.

    Research Support, Foundations and Societies:

    1. The Torsten Söderberg Foundation at the Royal Swedish Academy of Sciences, the Alzheimer Foundation, Sweden, the Stiftelsen för Gamla Tjänarinnor, Stockholm, Sweden and Hjärnfonden, Sweden.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Henrik Zetterberg, MD, PhD and
    4. Scientific Advisory Boards:

    1. HZ has served at advisory boards for Roche Diagnostics, Samumed, CogRx and Wave.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer's Disease, Associate Editor Alzheimer's & Dementia, Associate Editor DADM, Associate Senior Editor Molecular and Cellular Neuroscience, Editor Scandinavian Journal of Clinical and Laboratory Investigation, Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. HZ is co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Swedish State Support for Clinical Research (ALFGBG- 144341) and (2) the Knut and Alice Wallenberg Foundation

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Jonathan Cedernaes, MD, PhD
    5. Scientific Advisory Boards:

    1. (1) Victoria University PhD thesis evaluation committee member (400 AUD reimbursement)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) American College of Sports medicine, honoraria (400 USD)

    Editorial Boards:

    1. (1) Frontiers in Nutrition, Associate Editor, 2019 (just started)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Göran Gustafsson foundation; the Lars Hierta Memorial foundation; the Lisa and Johan Grönberg foundation; the Magnus Bergvall foundation; the Mats Kleberg’s foundation; the Sweden- America Foundation; the Swedish Brain foundation; the Swedish Society of Medicine; the Swedish Society for Medical Research; the Tore Nilson foundation; the Åke Wiberg Foundation.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neuroscience (C.B., J.C.) and Medical Sciences (J.C.), Uppsala University; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; and UK Dementia Research Institute at UCL (H.Z.), London, UK.
  1. Correspondence
    Dr. Cedernaes jonathan.cedernaes{at}medsci.uu.se
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