Article Figures & Data
Figures
- Figure 1 Effect of acute sleep loss on diurnal changes in plasma levels of total tau (t-tau)
(A) Change in plasma levels of t-tau, comparing the percent change from evening at 19:30 hours to the morning at 07:30 hours, between the normal sleep (absolute levels in the evening: 3.87 ± 0.52 pg/mL) and acute sleep loss condition (evening absolute levels: 3.00 ± 0.42 pg/mL) in 15 healthy young men. (B) The evening to morning change in plasma levels of t-tau across individuals, in response to normal sleep (black bars) and acute sleep loss (orange bars) (individuals arbitrarily numbered along the x axis; n = 15). *p < 0.05; grouped values shown as mean ± SEM.
- Figure 2 Effect of acute sleep loss on diurnal changes in plasma levels of amyloid β40 (Aβ40) and amyloid β42 (Aβ42)
(A) Change in plasma levels of Aβ40 from evening to 12 hours later in the morning (expressed as % change), after each of 2 overnight interventions, i.e., normal sleep (absolute levels in the evening: 29.9 ± 2.3 pg/mL) and acute sleep loss (evening: 28.3 ± 2.3 pg/mL) (n = 14). (B) Data from A shown at the individual level (participants arbitrarily numbered along the x axis), as the evening to morning change, in response to normal sleep (black bars) and acute sleep loss (orange bars). (C) Corresponding evening to morning change at the group level for plasma levels of Aβ42 (n = 14), across normal sleep (evening: 2.63 ± 0.13 pg/mL) and sleep loss (evening: 2.98 ± 0.16 pg/mL); also shown in D at the individual level (as in B).
- Figure 3 Effect of acute sleep loss on diurnal changes in plasma levels of neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP)
(A) Evening to morning change (expressed as % change) in plasma levels of NfL after normal sleep (absolute levels in the evening: 14.9 ± 2.0 pg/mL), and acute sleep loss (evening: 15.2 ± 2.3 pg/mL) (n = 13). (B) Individual evening to morning changes across the studied participants in plasma levels of NfL in response to normal sleep (black bars) or acute sleep loss (orange bars). (C) Change in plasma levels of GFAP in evening to morning after normal sleep (evening: 120 ± 50 pg/mL) and acute sleep loss (evening: 115 ± 42 pg/mL). (D) Individual evening to morning changes in plasma levels of GFAP in response to normal sleep and acute sleep loss (n = 15). Grouped values shown as mean ± SEM.
- Figure 4 Analysis of diurnal changes across sleep conditions in plasma levels of amyloid β40 (Aβ40), amyloid β42 (Aβ42), and glial fibrillary acid protein (GFAP)
Evening to morning change (expressed as % change) in plasma levels of (A) Aβ40 (n = 28), (B) Aβ42 (n = 28), and (C) GFAP (n = 30). Samples were pooled across conditions and are shown as mean ± SEM. ***p < 0.001.
Disputes & Debates: Rapid online correspondence
- Reader response: Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
- Reader response: Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within the last 8 weeks.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.