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March 17, 2020; 94 (11) ArticleOpen Access

Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men

View ORCID ProfileChristian Benedict, Kaj Blennow, Henrik Zetterberg, View ORCID ProfileJonathan Cedernaes
First published January 8, 2020, DOI: https://doi.org/10.1212/WNL.0000000000008866
Christian Benedict
From the Departments of Neuroscience (C.B., J.C.) and Medical Sciences (J.C.), Uppsala University; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; and UK Dementia Research Institute at UCL (H.Z.), London, UK.
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Kaj Blennow
From the Departments of Neuroscience (C.B., J.C.) and Medical Sciences (J.C.), Uppsala University; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; and UK Dementia Research Institute at UCL (H.Z.), London, UK.
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Henrik Zetterberg
From the Departments of Neuroscience (C.B., J.C.) and Medical Sciences (J.C.), Uppsala University; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; and UK Dementia Research Institute at UCL (H.Z.), London, UK.
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Jonathan Cedernaes
From the Departments of Neuroscience (C.B., J.C.) and Medical Sciences (J.C.), Uppsala University; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; and UK Dementia Research Institute at UCL (H.Z.), London, UK.
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Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
Christian Benedict, Kaj Blennow, Henrik Zetterberg, Jonathan Cedernaes
Neurology Mar 2020, 94 (11) e1181-e1189; DOI: 10.1212/WNL.0000000000008866

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    Figure 1 Effect of acute sleep loss on diurnal changes in plasma levels of total tau (t-tau)

    (A) Change in plasma levels of t-tau, comparing the percent change from evening at 19:30 hours to the morning at 07:30 hours, between the normal sleep (absolute levels in the evening: 3.87 ± 0.52 pg/mL) and acute sleep loss condition (evening absolute levels: 3.00 ± 0.42 pg/mL) in 15 healthy young men. (B) The evening to morning change in plasma levels of t-tau across individuals, in response to normal sleep (black bars) and acute sleep loss (orange bars) (individuals arbitrarily numbered along the x axis; n = 15). *p < 0.05; grouped values shown as mean ± SEM.

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    Figure 2 Effect of acute sleep loss on diurnal changes in plasma levels of amyloid β40 (Aβ40) and amyloid β42 (Aβ42)

    (A) Change in plasma levels of Aβ40 from evening to 12 hours later in the morning (expressed as % change), after each of 2 overnight interventions, i.e., normal sleep (absolute levels in the evening: 29.9 ± 2.3 pg/mL) and acute sleep loss (evening: 28.3 ± 2.3 pg/mL) (n = 14). (B) Data from A shown at the individual level (participants arbitrarily numbered along the x axis), as the evening to morning change, in response to normal sleep (black bars) and acute sleep loss (orange bars). (C) Corresponding evening to morning change at the group level for plasma levels of Aβ42 (n = 14), across normal sleep (evening: 2.63 ± 0.13 pg/mL) and sleep loss (evening: 2.98 ± 0.16 pg/mL); also shown in D at the individual level (as in B).

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    Figure 3 Effect of acute sleep loss on diurnal changes in plasma levels of neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP)

    (A) Evening to morning change (expressed as % change) in plasma levels of NfL after normal sleep (absolute levels in the evening: 14.9 ± 2.0 pg/mL), and acute sleep loss (evening: 15.2 ± 2.3 pg/mL) (n = 13). (B) Individual evening to morning changes across the studied participants in plasma levels of NfL in response to normal sleep (black bars) or acute sleep loss (orange bars). (C) Change in plasma levels of GFAP in evening to morning after normal sleep (evening: 120 ± 50 pg/mL) and acute sleep loss (evening: 115 ± 42 pg/mL). (D) Individual evening to morning changes in plasma levels of GFAP in response to normal sleep and acute sleep loss (n = 15). Grouped values shown as mean ± SEM.

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    Figure 4 Analysis of diurnal changes across sleep conditions in plasma levels of amyloid β40 (Aβ40), amyloid β42 (Aβ42), and glial fibrillary acid protein (GFAP)

    Evening to morning change (expressed as % change) in plasma levels of (A) Aβ40 (n = 28), (B) Aβ42 (n = 28), and (C) GFAP (n = 30). Samples were pooled across conditions and are shown as mean ± SEM. ***p < 0.001.

Disputes & Debates: Rapid online correspondence

  • Reader response: Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
    • Wei Liu, Neurosurgeon, Weihai Municipal Hospital
    • Dong-Yan Yu, Physician, Weihai Third Municipal Hospital
    Submitted January 18, 2020
  • Reader response: Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
    • Vinod K. Gupta, Physician-Director, Migraine-Headache Institute, Gupta Medical Centre (New Delhi, India)
    Submitted January 15, 2020
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