Share

March 24, 2020; 94 (12) Article

Thrombolysis for acute ischemic stroke in the unwitnessed or extended therapeutic time window

Georgios Tsivgoulis, Aristeidis H. Katsanos, Konark Malhotra, Amrou Sarraj, Andrew D. Barreto, Martin Köhrmann, Christos Krogias, Niaz Ahmed, Valeria Caso, Peter D. Schellinger, Andrei V. Alexandrov
First published December 31, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008904
Full PDF
Short Form
Citation
Permissions

Make Comment

See Comments

Downloads
920

Share

Article Information

vol. 94 no. 12 e1241-e1248
DOI: 
https://doi.org/10.1212/WNL.0000000000008904
PubMed: 
31892636
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 3, 2019
  • Accepted in final form September 30, 2019
  • First Published December 31, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Georgios Tsivgoulis, MD,
    2. Aristeidis H. Katsanos, MD,
    3. Konark Malhotra, MD,
    4. Amrou Sarraj, MD,
    5. Andrew D. Barreto, MD, MS,
    6. Martin Köhrmann, MD,
    7. Christos Krogias, MD,
    8. Niaz Ahmed, MD,
    9. Valeria Caso, MD,
    10. Peter D. Schellinger, MD and
    11. Andrei V. Alexandrov, MD
  1. Georgios Tsivgoulis, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Neuroimaging, Associate Editor for Neurosonology, 2009- Stroke, Editorial Board Member, 2015-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Aristeidis H. Katsanos, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Neuroimaging, Editorial Board Member Stroke, Editorial Board Member PLOS One, Guest Academic Editor Frontiers in Neurology, Guest Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Konark Malhotra, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Amrou Sarraj, MD,
    5. Scientific Advisory Boards:

    1. Stryker Neurovascular - Commercial

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Stryker Neurovascular - Commercial

    Editorial Boards:

    1. Frontiers in Neurology - Associate Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Stryker Neurovascular - Commercial

    Speakers' Bureaus:

    1. Stryker Neurovascular - Commercial

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Stryker Neurovascular - Commercial

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Andrew D. Barreto, MD, MS,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Martin Köhrmann, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Christos Krogias, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. honoraria for oral presentations or travel grants for scientific meetings from Bayer Vital, Daiichi-Sankyo, none related to this manuscript.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Niaz Ahmed, MD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I am chairman of SITS International, which received grant from Boehringer-Ingelheim. SITS is currently conducting studies supported by Boehringer-Ingelheim as well as in collaboration with Karolinska Institutet, supported by Stryker, Covidien and Phenox.

    Research Support, Government Entities:

    1. I am coordinating a phase III clinical trial for which we have received grants provided by the Swedish Research Council

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. I am chairman of SITS International, which is financed directly and indirectly by grants from Karolinska Institutet, Stockholm County Council, the Swedish Heart-Lung Foundation, the Swedish Order of St. John, Friends of Karolinska Institutet, and private donors. I am also supported by grants provided by the Stockholm County Council.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Valeria Caso, MD,
    10. Scientific Advisory Boards:

    1. Respect ESUS Bayer SPI

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Daichi-Sankyo BI Servier

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. speaker’s bureau of Boehringer Ingelheim, Bayer, daichi- Sankyo, Ever Pharma

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Peter D. Schellinger, MD and
    11. Scientific Advisory Boards:

    1. (1) Boehringer Ingelheim since 2003 (2) Daiichi Sankyo since 2014 (3) Cerevast until 2016 (4) Takeda 2017 (5) Portola 2019

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Boehringer Ingelheim since 2003 (2) Medtronic since 2015 (3) BMS/Pfizer since 2012 (4) Daiichi Sankyo since 2014 (5) Sun Pharma since 2016 (6) Cerevast until 2016 (7) Covidien until 2017

    Editorial Boards:

    1. (1) Stroke (2006-2009) (2) Journal of Stroke (2012-today)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NeuroIntensiv eds 1-3, Springer, since 2008

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Boehringer Ingelheim since 2003 (2) Daiichi Sankyo since 2014 (3) Cerevast until 2016

    Speakers' Bureaus:

    1. (1) Boehringer Ingelheim since 2003 (2) Medtronic since 2015 (3) BMS/Pfizer since 2012 (4) Daiichi Sankyo since 2014 (5) Sun Pharma since 2016 (6) Cerevast until 2016 (7) Covidien until 2017

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS, NIH 2003-2004

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Andrei V. Alexandrov, MD
    12. Scientific Advisory Boards:

    1. Commercial entity: Cerevast Therapeutics, Inc

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Cerebrovascular Diseases, Editorial Board member, 2011- present Interventional Neurology, EB Member, 2016-present

    Patents:

    1. “Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue” Inventors: Alexandrov AV, Aronowski J, Wojner AW US patent 6,733,450 (May 11, 2004) Assignee: Texas Systems, Board of Reagents

    Publishing Royalties:

    1. Alexandrov AV. Cerebrovascular Ultrasound in Stroke Prevention and Treatment. New York: Futura / Blackwell Publishing. 2003. ISBN 1- 4051-0381-7 Alexandrov AV. Cerebrovascular Ultrasound in Stroke Prevention and Treatment. Oxford: Blackwell Publishing (in Chinese) 2007. ISBN 7- 117-07389-6 Alexandrov AV. Cerebrovascular Ultrasound in Stroke Prevention and Treatment. (2nd Edition) Oxford: Wiley-Blackwell Publishers. 2011. 9781405195768.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Commercial entity: Cerevast Therapeutics, Inc.

    Speakers' Bureaus:

    1. Genentech, Inc

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Commercial entity: Cerevast Therapeutics, Inc.

    Research Support, Government Entities:

    1. ZODIAC trial, NINR (R01 pending)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Commercial entity: Cerevast Therapeutics, Inc.

    License fee payments, Technology or Inventions:

    1. “Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue” Inventors: Alexandrov AV, Aronowski J, Wojner AW US patent 6,733,450 (May 11, 2004) Assignee: Texas Systems, Board of Reagents Source of payment: Cerevast Therapeutics, Inc.

    Royalty Payments, Technology or Inventions:

    1. “Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue” Inventors: Alexandrov AV, Aronowski J, Wojner AW US patent 6,733,450 (May 11, 2004) Assignee: Texas Systems, Board of Reagents Source of payment: Cerevast Therapeutics, Inc.

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Second Department of Neurology (G.T., A.H.K.), “Attikon” University Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece; Department of Neurology (G.T., A.V.A.), University of Tennessee Health Science Center, Memphis; Department of Neurology (A.H.K., C.K.), St. Josef Hospital, Ruhr University Bochum, Germany; Department of Neurology (K.M.), Allegheny Health Network, Pittsburgh, Pennsylvania; Department of Neurology (A.S., A.D.B.), University of Texas Health Science Center, Houston; Department of Neurology (M.K.), Universitaetsklinikum Essen, Germany; Department of Neurology (N.A.), Karolinska University Hospital; Department of Clinical Neuroscience (N.A.), Karolinska Institute, Stockholm, Sweden; Stroke Unit and Division of Cardiovascular Medicine (V.C.), University of Perugia, Italy; and Departments of Neurology and Neurogeriatry (P.D.S.), Johannes Wesling Medical Center, Ruhr University Bochum, Minden, Germany.
  1. Correspondence
    Dr. Tsivgoulis tsivgoulisgiorg{at}yahoo.gr
View Full Text

Article usage

Article usage: December 2019 to January 2021

AbstractFullPdfSource
Dec 201910803Highwire
Jan 202024680157Highwire
Feb 2020600072Highwire
Mar 20201584227151Highwire
Apr 20205875979Highwire
May 20204311774Highwire
Jun 20202941344Highwire
Jul 20201841548Highwire
Aug 20202491245Highwire
Sep 20202701741Highwire
Oct 20202361058Highwire
Nov 20202741152Highwire
Dec 2020227454Highwire
Jan 20212071642Highwire

Cited By...

Disputes & Debates: Rapid online correspondence

Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

  • No related articles found.

Topics Discussed

Alert Me