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April 21, 2020; 94 (16) Article

Dietary flavonols and risk of Alzheimer dementia

Thomas M. Holland, Puja Agarwal, Yamin Wang, Sue E. Leurgans, David A. Bennett, Sarah L. Booth, Martha Clare Morris
First published January 29, 2020, DOI: https://doi.org/10.1212/WNL.0000000000008981
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Article Information

vol. 94 no. 16 e1749-e1756
DOI: 
https://doi.org/10.1212/WNL.0000000000008981
PubMed: 
31996451
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received May 24, 2019
  • Accepted in final form November 12, 2019
  • First Published January 29, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Thomas M. Holland, MD,
    2. Puja Agarwal, PhD,
    3. Yamin Wang, PhD,
    4. Sue E. Leurgans, PhD,
    5. David A. Bennett, MD,
    6. Sarah L. Booth, PhD and
    7. Martha Clare Morris, ScD
  1. Thomas M. Holland, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1)National Institute on Aging 2)RF1AG051641 3)Post Doctoral Fellow, 3 years

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Puja Agarwal, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. California Strawberry Commission: 02/01/2019- 01/31/20 Amount: $70,575 Project title: Association of Strawberry Consumption with Cognitive and Motor Decline as well as Brain Neuropathologies in Older Adults 2. Michael J. Fox Foundation for Parkinson’s Research: 05/2019- 05/2021 Amount: $220,489.37 Project Title: Association of dietary patterns including MIND, Mediterranean, DASH and Western diet with parkinsonian signs and presence of Lewy bodies, cerebral infarcts and other vascular neuropathologies in a community population of older adults Project

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Yamin Wang, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Sue E. Leurgans, PhD,
    5. Scientific Advisory Boards:

    1. NIH R21 to David A. Gallo, University of Chicago. I serve on the DSMB

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Neurology, Associate Editor for Statistics, 2015-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH: P30 AG010161 (ADC), core Leader and statistician, 2007-present (2) NIH: R01 AG042210, statistician, 2011-present (3) NIH: R01 NS078009, statistician, 2012-present (4) NIH: P20 MD006886, statistician 2013-present (5) NIH: RF1 AG015819, statisician, 2015-present (6) NIH: U02 AG046152-S1, statisician, 2015-Aug, 2018 (7) NIH R01 AG034374, statistician, 2015-present (8) NIH: R01 AG047976, statistician, 2014-present (9) NIH: R01 AG033570, statistician, 2015-present (10) NIH: R01 AG051641, statistician, 2016-present (11) NIH: R01 AG054476, statistician, 2016-present (12) NIH: R01 AG054057, statistician, 2016-present (13) NIH: UH2NS100599, statistician, 2016-present (14) NIH: R01 AG054058, statistician, 2017-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. David A. Bennett, MD,
    6. Scientific Advisory Boards:

    1. (1) Vigorous Minds, Scientific Advisory Board (2) AbbVie - Data Monitoring Committee (3) EABs: India Institute of Science; MCSA; Columbia ADRC; CCNA; CIMA-Q, WFU, Emory, MODEL-AD, REGARDS (4) DMCs: HRS, MIDUS (5) National Advisory Council on Aging

    Gifts:

    1. $100,000 Potamkin Prize from the American Brain Foundation

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Neurology, Editorial Board; (2) Current Alzheimer Research, Editorial Board; (3) Neuroepidemiology, Editorial Board (4) Journal of the Prevention of Alzheimer's Disease, Editorial Board (5) Journal of Alzheimer's Disease, Editorial Board (6) Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH: P30AG10161, PI; R01AG15819, PI; R01AG17917, PI; R01AG36042, MPI; R01AG54058, PI; U01AG61356, MPI; R01AG52476, MPI,

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Sarah L. Booth, PhD and
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Current Developments in Nutrition, Deputy Editor, 2016 to current

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 08/16/15-07/31/17 Abbott Laboratories Biomarkers of Healthy Brain Aging in the Illinois Elderly Adult Cohort The major goal of the project is to identify distinct nutrient biomarker patterns and examine association between these patterns and cognitive indices of brain health Role: Co-Investigator JohnsonIllinois2017 Johnson (PI)

    Research Support, Government Entities:

    1. 1R01AG051641-01A1 Booth/Morris (MPI) 09/01/16-08/30/21 NIH/NIA Vitamins D and K and Neuropathologically-Defined Alzheimer and Other Dementias in Older Persons The major goal of this project is to understand vitamin D and K’s role in Alzheimer's disease and related dementias of aging. Role: Contact PI 1950-51000-069-02S Booth (PI) 09/15/14-09/14/19 USDA/ARS Vitamin K and Vitamin K-Dependent Proteins During Aging The major goal of this project is to enhance scientific knowledge on the physiological benefits of increased vitamin K consumption in order to develop more precise vitamin K intake recommendations. Role: PI R01AR066378 McAlindon (PI) 04/01/15- 09/30/18 NIH/ NIAMS Constitutional and Metabolic Factors associated with the development of Hand OA The goal of this project is to evaluate and contrast the roles of structural and metabolic characteristics in the development of radiographic, symptomatic and erosive hand osteoarthritis. Role: Consortium PI Illinois2017 Booth (PI) K01 AR063167 Shea (PI) 08/01/12-07/31/17 NIH/NIAMS Identifying Vitamin K Dependent Pathways in Osteoarthritis Progression The purpose of the study is to determine the effect of vitamin K and D on osteoarthritis progression and elucidate mechanisms through which vitamins D & K influences cartilage homeostasis. Role: Mentor and Co-Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Martha Clare Morris, ScD
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIH/NIA - AG052583, PI, 2016-2021 2.NIH/NIA - AG054476, PI, 2017-2022 3. NIH/NIA - AG054057, MPI, 2016-2021 4. NIH/NIA - AG051641, MPI, 2016-2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From Rush Institute for Healthy Aging (T.M.H., P.A., Y.W., M.C.M.), Rush Alzheimer's Disease Center (S.E.L., D.A.B.), and Neurological Sciences (S.E.L., D.A.B.), Rush University Medical Center, Chicago, IL; and Jean Mayer USDA Human Nutrition Research Center on Aging (S.L.B.), Tufts University, Boston, MA.
  1. Correspondence
    Dr. Holland thomas_holland{at}rush.edu

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