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April 28, 2020; 94 (17) Article

Long-term exposure to air pollution and trajectories of cognitive decline among older adults

Erin R. Kulick, Gregory A. Wellenius, Amelia K. Boehme, Nina R. Joyce, Nicole Schupf, Joel D. Kaufman, Richard Mayeux, Ralph L. Sacco, Jennifer J. Manly, Mitchell S.V. Elkind
First published April 8, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009314
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Article Information

vol. 94 no. 17 e1782-e1792
DOI: 
https://doi.org/10.1212/WNL.0000000000009314
PubMed: 
32269113
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received October 7, 2018
  • Accepted in final form November 22, 2019
  • First Published April 8, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Erin R. Kulick, PhD, MPH,
    2. Gregory A. Wellenius, ScD,
    3. Amelia K. Boehme, PhD, MSPH,
    4. Nina R. Joyce, PhD,
    5. Nicole Schupf, PhD,
    6. Joel D. Kaufman, MD, MPH,
    7. Richard Mayeux, MD, MSc,
    8. Ralph L. Sacco, MD, MS,
    9. Jennifer J. Manly, PhD and
    10. Mitchell S.V. Elkind, MD, MS
  1. Erin R. Kulick, PhD, MPH,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Heart, Lung, and Blood Institute of the National Institutes of Health under award number T32HL134625, postdoctoral fellow, 2018-2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Gregory A. Wellenius, ScD,
    3. Scientific Advisory Boards:

    1. 1) Health Effects Institute

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1) Epidemiology, Editorial Board Member 2017 - Present 2) Environmental Epidemiology, Editorial Board Member, 2017- Present

    Patents:

    1. NONE

    Publishing Royalties:

    1. 1) Savitz DA, Wellenius GA. Interpreting Epidemiologic Evidence: Connecting Research to Applications. Oxford University Press; 2016.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Health Effects Institute

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIH, 2) US Department of Defense, 3) US Federal Aviation Administration

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) Robert Wood Johnson Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Amelia K. Boehme, PhD, MSPH,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS NIH R03 NS101417, NIH NIMHD R21 MD012451

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Consultant and expert testimony

  4. Nina R. Joyce, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Agency for Healthcare Research and Quality (AHRQ) K12 HS022998

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Nicole Schupf, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Non-profit entity. University of Southern California. Consult on the development of a clinical trials network for adults with Down syndrome

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1.NIH U01AG051412;PI, 09/30/2015-04/30/20 2.NIH R56AG034189; co-Invest 07/01/2009-08/31/2018 3.NIH R01AG049810; co-invest 03/15/2016-02/28/2021 4.NIH U01AG023749; co-invest 06/01/2004 - 05/31/2019 5.NIH 1RF1AG054070; co-invest 09/01/2016-06/30/2021 6. NIH RF1AG054023; co-invest 08/01/2016 - 06/30/2021 7. NIH P50AG008702; ADRC member,06/15/1997-05/31/2020 8. NIH R01AG043679; co-invest,09/01/2014-05/31/2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association: DSAD-15-364171: PI, 11/01/2015-10/31/2018

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Joel D. Kaufman, MD, MPH,
    7. Scientific Advisory Boards:

    1. (1) SPOUSE: Merck (2) SPOUSE: X-Vax (3) SPOUSE: Gilead Sciences

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) SPOUSE: Innovative Molecules (2) Amarin

    Editorial Boards:

    1. (1) American Journal of Respiratory and Critical Care Medicine, editorial board 2007-present (2) SPOUSE: STI, editorial board member (3) SPOUSE: STD, editorial board member (4) SPOUSE: Journal of Infectious Diseases, associate editor (5) SPOUSE: Journal Watch Women's Health, associate editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) SPOUSE: UpToDate (Wolters Kluwer), continuous, ongoing (2) SPOUSE: Journal Watch Women's Health (Massachusetts Medical Society), continuous, ongoing

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) SPOUSE: AiCuris

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) SPOUSE is funded as investigator in a clinical trial for Sanofi Pasteur

    Research Support, Government Entities:

    1. National Institutes of Health US Environmental Protection Agency US Department of Defense

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Richard Mayeux, MD, MSc,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant to the Alzheimer's Disease Center at Rush University Medical School

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. RF1AG054023 Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's Disease

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Ralph L. Sacco, MD, MS,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Ed Boards: Stroke, Neuroepidemiology

    Patents:

    1. NONE

    Publishing Royalties:

    1. Grotta J, Albers G, Broderick J, Kasner S, Lo E, Mendelow A, Sacco R, Wong L. Stroke, Pathophysiology, Diagnosis, and Management (6th ed.). Linn, MO: Elsevier, 2016

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Boehringer Ingelheim - Institutional research support for Steering Committee of Secondary Stroke Prevention Trial with Dabigatran (RESPECT ESUS Trial)

    Research Support, Government Entities:

    1. (1) NINDS, Northern Manhattan Study, PI, 1993-present R01 NS29993 (2) NINDS, Family Study, CoI, 2004-present R01 NS040807 (3) NINDS Stroke Prevention Intervention Research Program, PI, 2013-2018 (4) NCATS, Clinical Translational Science Award, PI, 2018- present (5) Florida Department of Health, Florida Stroke Registry

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Evelyn McKnight Brain Institute

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Jennifer J. Manly, PhD and
    10. Scientific Advisory Boards:

    1. Reimbursement of travel costs and AAIC registration associated with serving on the Medical and Scientific Advisory Board of the Alzheimer's Association

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. National Academies of Medicine - 2014 and 2017 National Academy of Sciences, 2018 - 2019

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIA R01AG016495, co-investigator, 09/15/2012- 06/30/2017 (2) NIDDK U01DK098246, co-investigator, 12/01/2012- 7/31/2017 (3) NIA R56AG034189, co-investigator, 09/01/2016 – 08/31/2017 (4) NINDS U01NS041588, co-investigator, 09/01/2001- 11/30/2017 (5) NIA R00AG47963, co-investigator, 09/01/2016- 08/31/2019 (6) NIA U01AG032984, co-investigator, 07/01/2015- 06/30/2020 (7) NIA U01DK048404, co-investigator, 08/15/1994- 01/31/2021 (8) NIA U54AG052427, co-investigator, 04/15/2016- 02/28/2021 (9) NIA R01AG049810, co-investigator, 03/15/2016- 02/28/2021 (10) NIA RF1AG054070, co-PI, 07/01/2016-03/31/2021 (11) NIA RF1AG056164, PI, 09/15/2016-06/30/2021 (12) NIA RF1AG054023, co-investigator, 09/01/2016- 06/30/2021 (13) NIA P30AG059303, co-PI, 04/01/18 - 03/31/23

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Mitchell S.V. Elkind, MD, MS
    11. Scientific Advisory Boards:

    1. Vascular Dynamics, interventional treatment for hypertension (2018-2019)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Stroke, Editor of International Stroke Early Career and Training Section, published by AHA (2017-2019)

    Patents:

    1. NONE

    Publishing Royalties:

    1. UpToDate, 2015-2019, chapters on cryptogenic stroke and hemicraniectomy for acute stroke

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Abbott, consulting regarding cryptogenic stroke (2017- 2018)

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. (1) American Heart Association National Board of Directors (2014-2022); (2) American Heart Association Founders Affiliate Board of Directors(2008-2016); (2) American Heart Association NY City Board of Directors (2011-2017)

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) BMS-Pfizer Alliance, provides drug in kind for support of clinical trial of aspirin vs apixaban for cryptogenic stroke; (2) Roche, provides lab support for support of clinical trial of aspirin vs apixaban for cryptogenic stroke and stroke (2014-2016)

    Research Support, Government Entities:

    1. (1) NIH/NINDS R01 29993, PI, 2007-2020 (2) NIH/NINDS P50 NS049060, Project 1, PI, NeuSTART, 2004- 2016 (3) NIH/NINDS U01 NS095869, PI, ARCADIA, 2017-2022

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. (1) Organon/Merck, NuvaRing and stroke litigation, 2009- 2018; (2) Auxilium, testosterone and stroke litigation (2017-2018); (3) Sorin (LivaNova), cardiac surgical devices and stroke (2018-2019)

  1. From the Department of Epidemiology (E.R.K., G.A.W., N.R.J.), Brown University School of Public Health, Providence, RI; Departments of Neurology (E.R.K., A.K.B., N.S., M.S.V.E.) and Psychiatry (R.M.) and Gertrude H. Sergievsky Center (N.S., R.M., J.J.M., M.S.V.E.), Vagelos College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health (E.R.K., A.K.B., N.S., R.M., J.J.M., M.S.V.E.), and Taub Institute for Research on Alzheimer Disease and the Aging Brain (N.S., R.M., J.J.M.), Columbia University, New York, NY; Departments of Environmental and Occupational Health Sciences, Medicine, and Epidemiology (J.D.K.), University of Washington, Seattle; and Departments of Neurology, Public Health Sciences, and Human Genetics (R.L.S.), Evelyn McKnight Brain Institute, Miller School of Medicine, University of Miami, FL.
  1. Correspondence
    Dr. Kulick erin_kulick{at}brown.edu
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