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April 28, 2020; 94 (17) Resident & Fellow Section

Mystery Case: Anti-NMDAR encephalitis with overlapping demyelinating syndrome

Hyun Woo Kim, Christopher Lamb, Sheheryar Jamali, Alfonso Sebastian Lopez Chiriboga
First published March 31, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009320
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    Brain MRI findings in anti-NMDAR encephalitis with overlapping MOG-IgG–associated demyelinating syndrome (A) Axial T2-FLAIR brain MRI from September 2018 showing right greater than left T2 hyperintensities in the mesial temporal lobes, (B) in the right posterior limb of the internal capsule, and (C) in the right periventricular white matter tracts. (D) Axial T1 gadolinium-enhanced brain MRI showing right pontine crescent-shaped contrast enhancement and (E) punctate enhancement in the right pons and (F) in the right posterior limb of the internal capsule and thalamus. (G and H) Axial T2-FLAIR brain MRI from June 2007 showing T2 hyperintensities in the right subcortical region and periventricular white matter tracts. (I and J) Axial T2-FLAIR brain MRI from November 2007 showing largely resolved lesions.

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