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May 05, 2020; 94 (18) Resident & Fellow Section

Teaching NeuroImages: Infantile-onset Krabbe disease with tigroid appearance of the white matter

E. Corina Andriescu, S. Nicholas Russo, View ORCID ProfileCarlos A. Pérez
First published April 8, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009380
E. Corina Andriescu
From the McGovern Medical School (E.C.A.), Division of Child and Adolescent Neurology, Department of Pediatrics (S.N.R.), and Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology (C.A.P.), University of Texas Health Science Center at Houston.
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S. Nicholas Russo
From the McGovern Medical School (E.C.A.), Division of Child and Adolescent Neurology, Department of Pediatrics (S.N.R.), and Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology (C.A.P.), University of Texas Health Science Center at Houston.
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Carlos A. Pérez
From the McGovern Medical School (E.C.A.), Division of Child and Adolescent Neurology, Department of Pediatrics (S.N.R.), and Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology (C.A.P.), University of Texas Health Science Center at Houston.
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Teaching NeuroImages: Infantile-onset Krabbe disease with tigroid appearance of the white matter
E. Corina Andriescu, S. Nicholas Russo, Carlos A. Pérez
Neurology May 2020, 94 (18) e1964-e1965; DOI: 10.1212/WNL.0000000000009380

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    Figure Imaging

    (A–D) Axial T2-weighted views. (A, B) Bilateral symmetric hyperintensity of the periventricular and deep cerebral white matter with a tigroid appearance. (C) Bilateral T2 thalamic hypointensities (arrowheads) and predominant parieto-occipital white matter involvement. (D) Normal, nonenlarged optic nerves. (E–H) Coronal T2-weighted views. (E) Bilateral symmetric hyperintensity of the periventricular and deep cerebral white matter with a tigroid appearance. (F) Peridentate cerebellar white matter hyperintensities (arrows). (G) Bilateral T2 thalamic hypointensities (arrowheads). (H) Normal, nonenlarged optic nerves.

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