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May 26, 2020; 94 (21) Article

Effect of yoga as add-on therapy in migraine (CONTAIN)

A randomized clinical trial

View ORCID ProfileAnand Kumar, Rohit Bhatia, Gautam Sharma, Dhanlika Dhanlika, Sreenivas Vishnubhatla, Rajesh Kumar Singh, Deepa Dash, Manjari Tripathi, M.V. Padma Srivastava
First published May 6, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009473
Anand Kumar
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Rohit Bhatia
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Gautam Sharma
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Dhanlika Dhanlika
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Sreenivas Vishnubhatla
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Rajesh Kumar Singh
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Deepa Dash
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Manjari Tripathi
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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M.V. Padma Srivastava
From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.
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Effect of yoga as add-on therapy in migraine (CONTAIN)
A randomized clinical trial
Anand Kumar, Rohit Bhatia, Gautam Sharma, Dhanlika Dhanlika, Sreenivas Vishnubhatla, Rajesh Kumar Singh, Deepa Dash, Manjari Tripathi, M.V. Padma Srivastava
Neurology May 2020, 94 (21) e2203-e2212; DOI: 10.1212/WNL.0000000000009473

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Abstract

Objective To evaluate the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine.

Methods CONTAIN was a prospective, randomized, open-label superiority trial with blinded endpoint assessment carried out at a single tertiary care academic hospital in New Delhi, India. Patients enrolled were aged 18–50 years with a diagnosis of episodic migraine and were randomized into medical and yoga groups (1:1). Randomization was computer-generated with a variable block size and concealed. A predesigned yoga intervention was given for 3 months. Outcomes were recorded by a blinded assessor. The primary endpoint was a decrease in headache frequency, headache intensity, and Headache Impact Test (HIT)–6 score. Secondary outcomes included change in Migraine Disability Assessment (MIDAS) score, pill count, and proportion of headache free patients.

Results Between April 2017 and August 2018, 160 patients with episodic migraine were randomly assigned to medical and yoga groups. A total of 114 patients completed the trial. Baseline measures were comparable except for a higher mean headache frequency in the yoga group. Compared to medical therapy, the yoga group showed a significant mean delta value reduction in headache frequency (delta difference 3.53 [95% confidence interval 2.52–4.54]; p < 0.0001), headache intensity (1.31 [0.60–2.01]; p = 0.0004), HIT score (8.0 [4.78–11.22]; p < 0.0001), MIDAS score (7.85 [4.98–10.97]; p < 0.0001), and pill count (2.28 [1.06–3.51]; p < 0.0003).

Conclusion Yoga as an add-on therapy in migraine is superior to medical therapy alone. It may be useful to integrate a cost-effective and safe intervention like yoga into the management of migraine.

Clinicaltrials.gov identifier CTRI/2017/03/008041.

Classification of evidence This study provides Class III evidence that for patients with episodic migraine, yoga as adjuvant to medical therapy improves headache frequency, intensity, impact, and disability.

Glossary

AIIMS=
All India Institute of Medical Sciences;
CGRP=
calcitonin gene-related peptide;
CI=
confidence interval;
CIMR=
Centre for Integrated Medicine and Research;
HIT=
Headache Impact Test;
ICHD-3 beta=
International Classification of Headache Disorders, 3rd edition (beta version);
ITT=
intention to treat;
MIDAS=
Migraine Disability Assessment questionnaire;
NO=
nitric oxide;
PP=
per protocol

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Class of Evidence: NPub.org/coe

  • CME Course: NPub.org/cmelist

  • Received May 31, 2019.
  • Accepted in final form November 22, 2019.
  • © 2020 American Academy of Neurology
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