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May 26, 2020; 94 (21) Article

Aerobic exercise improves cognition and cerebrovascular regulation in older adults

Veronica Guadagni, Lauren L. Drogos, Amanda V. Tyndall, Margie H. Davenport, Todd J. Anderson, Gail A. Eskes, R. Stewart Longman, Michael D. Hill, David B. Hogan, Marc J. Poulin
First published May 13, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009478
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Article Information

vol. 94 no. 21 e2245-e2257
DOI: 
https://doi.org/10.1212/WNL.0000000000009478
PubMed: 
32404355
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received July 9, 2019
  • Accepted in final form November 22, 2019
  • First Published May 13, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Veronica Guadagni, PhD,
    2. Lauren L. Drogos, PhD,
    3. Amanda V. Tyndall, PhD,
    4. Margie H. Davenport, PhD,
    5. Todd J. Anderson, MD,
    6. Gail A. Eskes, PhD,
    7. R. Stewart Longman, PhD,
    8. Michael D. Hill, MD, PhD,
    9. David B. Hogan, MD and
    10. Marc J. Poulin, PhD, DPhil
  1. Veronica Guadagni, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer Society of Canada Postdoctoral Fellowship, 2 years (September 2018-August 2020)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Lauren L. Drogos, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Amanda V. Tyndall, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Margie H. Davenport, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Heart and Stroke Foundation of Canada National New Investigator award.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Todd J. Anderson, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Local PI - Amgen Fourier Study Local PI - Dal-cor Dalgene study

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Gail A. Eskes, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Nova Scotia Health Research Foundation,co-PI, 2018-2020 (2) Research Nova Scotia, co-I, 201nine-2020 (3) Nova Scotia Health Authority Translating Research into Care (TRIC) operating grant, PI, 2016-2018 (4) Innovacorp Early Stage Commercialization Fund, PI, 2017-2018 (5) Canadian Institutes for Health Research, co-I, 2015-2020 Immediate Family Member:: (1)NSERC operating grant,RGPIN0305, PI, 2013-2020 (2) Hong Kong Research Grants Council,co-I,2017-2020 (3) CIHR Community Development Program, co-I, 2015-2020

    Research Support, Academic Entities:

    1. (1)Dalhousie University

    Research Support, Foundations and Societies:

    1. (1) Centre for Aging and Brain Health Innovation (2) Heart & Stroke Foundation Canadian Partnerships for Stroke Recovery (3) Heart & Stroke Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. R. Stewart Longman, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. Private practice in neuropsychological assessment

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Michael D. Hill, MD, PhD,
    9. Scientific Advisory Boards:

    1. Vernalis Group Ltd Advisory board - 2008 Genentech Ltd Advisory board - 2007 Sanofi Canada Ltd Advisory board - 2009 Hoffmann-La Roche Canada Ltd advisory board - 2010 Bayer Canada Advisory Board - 2011 Boehringer-Ingelheim Canada Advisory Board - 2011 BMS-Pfizer Alliance Advisory Board - 2015 Columbus Registry Steering Committee (Boehringer-Ingelheim) - 2018-2019 Tenecteplase Ad Board - Boehringer Ingehelheim 2019-present ARUBA study DSMB - ended 2013 SHINE study DSMB - ended 2019 Aldagen study DSMB - ended 2014 BRAIN-AF study DSMB - ongoing ARTESIA study DSMB - ongoing RACECAT study DSMB - ongoing

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board - Stroke (ongoing), Can J Neurological, Sciences (ongoing), International Journal of Stroke (ongoing), Neurology (ended 2010) Editor - Stroke Rounds (Canada) (ended 2010) Associate Editor - International Journal of Stroke (2017 - ongoing)

    Patents:

    1. Patent granted. 62/086,077 Systems and Methods for Assisting in Decision-Making and Triaging for Acute Stroke Patients

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Heart & Stroke Foundation Alberta/NWT/NU Board of Directors - 2009-2011 [Charitable sector] Heart & Stroke Foundation Alberta/NWT/NU Advisory Board of Directors (Past-Chair) - 2011-2015 [Charitable sector] Canadian Neuroscience Federation - 2012-2016 Board of Directors [Not-for-profit sector] QuikFLO Health Inc. - 2015-2016 - Board of Directors [For profit sector]. Today, no longer a board member due to resignation. Circle NVI - 2019-onwards - Board of Directors

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Grant funding from industry - Hoffmann-La Roche Canada 2004 & 2009, Bayer Canada 2007, Merck Canada 2003-2007, Covidien(Medtronic) 2013-2017, Boehringer- Ingelheim 2016-present,Stryker 2017-present, NoNO Inc 2019- present

    Research Support, Government Entities:

    1. NIH (NINDS) (2001-ongoing) CIHR (1999-ongoing) (Public funding sector) Alberta Heritage Foundation for Medical Research (2007-2014) (Public funding sector) Alberta Innovates Health Solutions 2014-2020 (Public funding sector)

    Research Support, Academic Entities:

    1. Canadian Stroke Network (2008-2013) [Public funding sector]

    Research Support, Foundations and Societies:

    1. Heart & Stroke Foundation Alberta (1999-ongoing) [Charitable funding sector] Stock/Stock Options, Medical Equipment & Materials: Calgary Scientific Incorporated (hold stock).

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. David B. Hogan, MD and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. CIHR (One of 9 PIs on Team Grant titled "Broad and Deep Analyses in Neurodegeneration [BRAIN]"; amount $4,224,487 over 5 years [2016-17 tp 2019-20]); $300,000 provided for project I lead 2. CIHR (Calgary site PI for Canadian Longitudinal Study on Health and Aging; total amount for all study sites participating $80,606,000 [2015-2021]) 3. Centre for Aging and Brain Health Innovation (Local PI); total amount received $14,851.25

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Marc J. Poulin, PhD, DPhil
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  1. Correspondence
    Dr. Poulin poulin{at}ucalgary.ca
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