Association of CD14 with incident dementia and markers of brain aging and injury

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.