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February 04, 2020; 94 (5) Editorial

Brain frailty and small vessel disease for stroke outcome prediction

Are we there yet?

Nawaf Yassi, Leon Flicker, Bruce C.V. Campbell
First published December 27, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008880
Nawaf Yassi
From the Department of Medicine and Neurology (N.Y, B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health (N.Y, B.C.V.C.), University of Melbourne; Population Health and Immunity Division (N.Y.), Walter and Eliza Hall Institute of Medical Research, Parkville; and Western Australian Centre for Health & Ageing (L.F.), Medical School, University of Western Australia, Perth, Australia.
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Leon Flicker
From the Department of Medicine and Neurology (N.Y, B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health (N.Y, B.C.V.C.), University of Melbourne; Population Health and Immunity Division (N.Y.), Walter and Eliza Hall Institute of Medical Research, Parkville; and Western Australian Centre for Health & Ageing (L.F.), Medical School, University of Western Australia, Perth, Australia.
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Bruce C.V. Campbell
From the Department of Medicine and Neurology (N.Y, B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health (N.Y, B.C.V.C.), University of Melbourne; Population Health and Immunity Division (N.Y.), Walter and Eliza Hall Institute of Medical Research, Parkville; and Western Australian Centre for Health & Ageing (L.F.), Medical School, University of Western Australia, Perth, Australia.
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Citation
Brain frailty and small vessel disease for stroke outcome prediction
Are we there yet?
Nawaf Yassi, Leon Flicker, Bruce C.V. Campbell
Neurology Feb 2020, 94 (5) 191-192; DOI: 10.1212/WNL.0000000000008880

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In patients with acute stroke, early prognostication and prediction of treatment response are key components of routine care and form an important part of communication with patients and their families. Traditionally, the prognostic factors that drive this clinical process can be roughly classified into stroke-specific factors such as stroke severity, infarct volume, or intracerebral hematoma volume and patient-specific factors such as age, comorbid medical conditions, and premorbid disability. In addition to these considerations, a prognostic tool that measures brain resilience or vulnerability to stroke would have clear clinical utility.

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • See page 195

  • © 2019 American Academy of Neurology
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