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September 22, 2020; 95 (12) Article

Clinician-judged hearing impairment and associations with neuropathologic burden

Willa D. Brenowitz, Lilah M. Besser, Walter A. Kukull, C. Dirk Keene, M. Maria Glymour, Kristine Yaffe
First published August 5, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010575
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Article Information

vol. 95 no. 12 e1640-e1649
DOI: 
https://doi.org/10.1212/WNL.0000000000010575
PubMed: 
32759190
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 9, 2019
  • Accepted in final form March 30, 2020
  • First Published August 5, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Willa D. Brenowitz, PhD, MPH,
    2. Lilah M. Besser, PhD, MSPH,
    3. Walter A. Kukull, PhD,
    4. C. Dirk Keene, MD, PhD,
    5. M. Maria Glymour, ScD and
    6. Kristine Yaffe, MD
  1. Willa D. Brenowitz, PhD, MPH,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIA T32AG049663, trainee, 2017-2019 NIH/NIA K01AG062722, PI, 2019-current UCSF Claude D. Pepper Older Americans Independence Center funded by National Institute on Aging, P30 AG044281, REC scholar, 2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association, AARF-18-565846

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Lilah M. Besser, PhD, MSPH,
    3. Scientific Advisory Boards:

    1. (1) National Institute on Aging Scientific Review Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) International Journal of Environmental Research and Public Health, section editor, 2019-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Walter A. Kukull, PhD,
    4. Scientific Advisory Boards:

    1. Special Emphasis Panels for grant review of NIH and CDC applications; External Advisory Committees for Alzheimer's disease centers: UCI, USC, U Kansas, Mt Sinai(NY), Boston U and Biocard study at JHU

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Univ of Florida, Gainesville. travel and lodging to give a talk on Alzheimer's disease. Feb, 2012. Travel for talk at Changchun University, China,2015 Travel for talk at Dongzhimen Hospital, Beijing, China 2016 honorarium: PKU Peoples hospital,Beijing, China 2018, 2019

    Editorial Boards:

    1. Editorial board member 2002-present: Alzheimer's Disease and Associated Disorders (no pay) Senior Associate Editor, Alzheimer's and Dementia, 2015 - present. (no pay)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. 1) External Advisory committee: UC Irvine ADRC 2)External Advisory committee: Mt Sinai ADRC 3) External Advisory committee:University of Kansas ADRC 4) Scientific Advisory Committee: Biocard Study, JHU 5) External advisory committee Boston U. ADRC 6)External Advisory Committee, USC ADRC

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institute on Aging, U01 AG016976,1999-present, PI as obtained through the University of Washington Co-investigator, Alzheimer's Disease Genetics Consortium (NIA grant; G. Schellenberg, U Penn, PI) co-investigator B-val study (NIH/NIA Michael Weiner, UCSF, PI; Co-Investigator ADOPIC study (NIH/NIA C. Masters, U Melbourne, PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association, Lumbar puncture survey study LPSS 11-219245 Principal Investigator

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. C. Dirk Keene, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. American Journal of Pathology, Editorial Board, 2013- present

    Patents:

    1. NONE

    Publishing Royalties:

    1. UpToDate, 2016-present

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH U01 AG006781 co-I 2015-20 NIH P50 AG05136 co-I 2015-20 NIH P30 AG049638 co-I 2016-21 NIH U01 NS086625 co-I 2014-17 NIH R01 ES026187-01A1 co-I, 2016-21

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Paul Allen Family Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. M. Maria Glymour, ScD and
    6. Scientific Advisory Boards:

    1. Organizing committee for the MEthods in Longitudinal Research on DEMentia (MELODEM) initiative (no compensation; paid travel expenses and lodging at the meeting)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. J Causal Inference, Associate editor, 2016- PLOS one, Academic editor, 2012- American Journal of Epidemiology, Associate Editor 2015-2019 (no compensation for any) Am J Epi, Associate Editor 2019-

    Patents:

    1. NONE

    Publishing Royalties:

    1. Social Epidemiology, 2nd edition, Oxford University Press 2014

    Employment, Commercial Entity:

    1. I have been a full time employee of the University of California, San Francisco, as an associate professor or professor, for over 6 years.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Past: NIH/NIA, Co-I, 9/31/2011-8/31/2016; (6) NIH/NICHD, Co- I; 7/1/10 - 6/31/12; (7) Office for Minority Health and Health Disparities, NIH; Role: Co-I; (8) NIH/NIA, Co-I, 9/1/2011-8/31/2016; NIH/NIA, Co-I, 10/1/2010-9/31/2012; Current: No number available 04/01/18-03/31/20 Robert Wood Johnson Foundation Evidence for Action National Program Office Associate Director 1R01AG051170 09/15/15-05/31/20 NIH/NIA Co-I 1RF1AG052132 06/01/16-05/31/21 NIH/NIA mPI RF1AG056164 09/01/16-06/30/21 NIH/NIA Co-I 1RF1AG050782-01A1 01/01/17-12/31/21 NIH/NIA Co-I RF1AG055486 06/15/17-05/31/21 NIH/NIA mPI R01EY027004 07/01/2017-05/31/2021 NIH/NEI co-I RF1AG056519 (Whitmer) 07/01/2017-06/30/2022 NIH/NIA Co-I P01AG041710 (Berkman) 09/30/2017-05/31/2022 NIH/NIA Co-I 1R01AG054066-01A1 (Berkman) 9/1/2018- 8/31/2023 NIH/NIA Co-I R01AG057869 (Glymour/Power) 09/01/2018-04/30/2023 NIH/NIA mPI R01AG059872 (Glymour) 08/15/2018-04/30/2022 NIH/NIA PI R56AG062165 (Portacolone) 09/01/2018 – 08/31/2019 NIH/NIA Co-I R01DK116738 (Jorgenson/Ahituv) 09/15/2018-08/31/2021 NIH/NEI Co-I 1R01HD090014 (Osypuk) 09/19/2017-05/31/2021 NIH/NICHD Co-I 7R01AG056360-02 (Yen) 07/01/2017-06/30/2021 NIH/NIA Co-I 1R01AG063385-01A1 (Hamad) 04/01/2019 – 03/31/2024 NIH/NIA Co-I P30 AG062422 (Miller) 04/01/2019 – 03/31/2024 NIH/NIA Co-I Additional NIH/NIA

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) American Heart Association Scientist Development Grant #10SDG2640243, PI, 1/1/10 – 12/31/14 (2) Robert Wood Johnson Foundation, Evidence for Action Grants Program, associate director, 2015-(this supports part of my salary)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Kristine Yaffe, MD
    7. Scientific Advisory Boards:

    1. 1)DSMB for Eli Lilly 2)DSMB for NIH sponsored trial 3)Beeson Scientific Advisory Board 4)Global Council on Brain Health 5)Board member of Alector

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry -Editorial Board Member 2014-, Journal of Prevention of Alzheimer’s Disease - Editorial Board Member 2017-, Alzheimer’s & Dementia: Translational Research & Clinical Interventions - Editorial Board Member 2018-, Translational Neurodegeneration

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIA K24 AG031155 06/13-11/20 PI:Yaffe Predictors of cognitive aging across the lifecourse 2. Sierra-Pacific VISN 10/09-09/23 Director Mental Illness Research, Educational and Clinical Center Psychiatric Fellowship 3. Sierra-Pacific VISN 10/09-09/23 PI of Dementia Research at SFVA Mental Illness Research, Educational and Clinical Center 4. Department of Defense W81XWH-16-1-0507 08/16-08/20 PI:Yaffe Risk and Resiliency for Dementia: Comparison of Male and Female Veterans 5. NIA RF1 AG054443 05/17-04/21 Multiple PI: Yaffe/ Zeki-Al Hazzouri Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment 6. NIA R01 AG057508 09/17-11/21 Multiple PI: Yaffe/Larson Systematic Multidomain Alzheimers Risk Reduction Trial (SMARRT) 7. NIA R01 AG054073 09/17-05/22 Multiple PI: Yaffe/O’Bryant/Toga Health Disparities in Alzheimer’s Disease and Mild Cognitive Impairment among Mexican Americans 8. NIA R01 AG058537 06/18-05/21 Multiple PI: Yaffe/O’Bryant An Alzheimer’s Blood Test for Primary Care 9. Department of Army W81XWH-18-1-0692 09/18-09/21 Multiple PI: Yaffe/Plassman Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia 10. NIA R01 AG063887 09/19-05/23 Multiple PI: Yaffe/Sidney Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer’s and Dementia Prevention 11. NIA R01 AG066137 09/19-06/24 Multiple PI: Yaffe/O’Bryant Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic Whites (HABLE-Dormir) 12. Department of Defense W81XWH-19-1-0669 10/19-09/23 Multiple PI: Yaffe/Gardner/Tosun Neuroimaging Endophenotypes & Predictors Post-TBI Dementia in A Nationwide Cohort of Veterans 13. Department of Defense/VA W81XWH-18-PH/TBIRP-LIMBIC I01CX002096 10/19-09/24 PI: Yaffe Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiological Study

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists 2) Alzheimer’s Drug Discovery Foundation Connection Between Depressive Symptoms and Dementia:When Best to Intervene?

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Psychiatry and Behavioral Sciences (W.D.B., K.Y.) and Neurology (K.Y.), Weill Institute for Neurosciences, and Department of Epidemiology & Biostatistics (M.M.G., K.Y.), University of California, San Francisco; Florida Atlantic University (L.M.B.), Institute for Human Health and Disease Intervention, School of Urban and Regional Planning, Boca Raton; National Alzheimer's Coordinating Center (W.A.K.), Department of Epidemiology, and Department of Pathology (C.D.K.), University of Washington, Seattle; and San Francisco VA Health Care System (K.Y.), CA.
  1. Correspondence
    Dr. Brenowitz willa.brenowitz{at}ucsf.edu
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