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September 29, 2020; 95 (13) Article

Short- and long-term outcome of patients with aneurysmal subarachnoid hemorrhage

View ORCID ProfileJaume Roquer, Elisa Cuadrado-Godia, Leopoldo Guimaraens, Gerardo Conesa, Ana Rodríguez-Campello, Jaume Capellades, María P. García-Arnillas, Juan L. Fernández-Candil, Carla Avellaneda-Gómez, Eva Giralt-Steinhauer, Jordi Jiménez-Conde, View ORCID ProfileCarolina Soriano-Tárraga, Gloria Villalba-Martínez, Rosa M. Vivanco-Hidalgo, Elio Vivas, View ORCID ProfileAngel Ois
First published August 13, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010618
Jaume Roquer
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Elisa Cuadrado-Godia
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Leopoldo Guimaraens
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Gerardo Conesa
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Ana Rodríguez-Campello
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Jaume Capellades
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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María P. García-Arnillas
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Juan L. Fernández-Candil
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Carla Avellaneda-Gómez
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Eva Giralt-Steinhauer
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Jordi Jiménez-Conde
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Carolina Soriano-Tárraga
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Gloria Villalba-Martínez
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Rosa M. Vivanco-Hidalgo
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Elio Vivas
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Angel Ois
From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei d’Anestèsia i Reanimació (J.L.F.-C.), IMIM–Hospital del Mar, Barcelona; and Departament de Medicina (J.R., E.C.-G., A.R.-C., A.O.), Universitat Autònoma de Barcelona i DCEXS-Universitat Pompeu Fabra, Spain.
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Short- and long-term outcome of patients with aneurysmal subarachnoid hemorrhage
Jaume Roquer, Elisa Cuadrado-Godia, Leopoldo Guimaraens, Gerardo Conesa, Ana Rodríguez-Campello, Jaume Capellades, María P. García-Arnillas, Juan L. Fernández-Candil, Carla Avellaneda-Gómez, Eva Giralt-Steinhauer, Jordi Jiménez-Conde, Carolina Soriano-Tárraga, Gloria Villalba-Martínez, Rosa M. Vivanco-Hidalgo, Elio Vivas, Angel Ois
Neurology Sep 2020, 95 (13) e1819-e1829; DOI: 10.1212/WNL.0000000000010618

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Abstract

Objective To describe short-term and 5-year rates of mortality and poor outcome in patients with spontaneous aneurysmal subarachnoid hemorrhage (aSAH) who received repair treatment.

Methods In this prospective observational study, mortality and poor outcome (modified Rankin Scale score 3–6) were analyzed in 311 patients with aSAH at 3 months, 1 year, and 5 years follow-up. Sensitivity analysis was performed according to treatment modality. In-hospital and 5-year complications were analyzed.

Results Of 476 consecutive patients with spontaneous subarachnoid hemorrhage, 347 patients (72.9%) had aSAH. Of these, 311 (89.6%) were treated (242 endovascular, 69 neurosurgical), with a mean follow-up of 43.4 months (range, 1 to 145). Three-month, 1-year, and 5-year mortality was 18.4%, 22.9%, and 29.0%, and poor outcome was observed in 42.3%, 36.0%, and 36.0%, respectively. Adjusted poor outcome was lower in endovascular than in neurosurgical treatment at 3 months (odds ratio [OR] 0.36 [95% confidence interval [CI] 0.18-0.74]), with an absolute difference of 15.8% (number needed to treat = 6.3), and at 1 year (OR = 0.40 [95% CI 0.20-0.81]), with an absolute difference of 15.9% (number needed to treat = 6.3). Complications did not differ between the 2 procedures. However, mechanical ventilation was less frequent with the endovascular technique (OR 0.67 [95% CI 0.54–0.84]).

Conclusions Patients with aSAH treated according to current guidelines had a short-term mortality of 18.4% and 5-year mortality of 29%. The majority (64.0%) of patients remained alive without disabilities at 5-year follow-up. Patients prioritized to endovascular treatment had better outcomes than those referred to neurosurgery because endovascular coiling was not feasible.

Glossary

aSAH=
aneurysmal subarachnoid hemorrhage;
BRAT=
Barrow Ruptured Aneurysm Trial;
CI=
confidence interval;
DCI=
delayed cerebral ischemia;
ICU=
intensive care unit;
OR=
odds ratio;
ISAT=
International Subarachnoid Aneurysm Trial;
mRS=
modified Rankin Scale;
NNT=
number needed to treat;
SAH=
subarachnoid hemorrhage

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Patient page e1915

  • Received October 6, 2019.
  • Accepted in final form June 8, 2020.
  • © 2020 American Academy of Neurology
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