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September 29, 2020; 95 (13) Null Hypothesis

Internet-based self-help randomized trial for motor functional neurologic disorder (SHIFT)

Jeannette M. Gelauff, Judith G.M. Rosmalen, Alan Carson, Joke M. Dijk, Martijn Ekkel, Glenn Nielsen, Jon Stone, Marina A.J. Tijssen
First published July 20, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010381
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Article Information

vol. 95 no. 13 e1883-e1896
DOI: 
https://doi.org/10.1212/WNL.0000000000010381
PubMed: 
32690783
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 23, 2019
  • Accepted in final form April 7, 2020
  • First Published July 20, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Jeannette M. Gelauff, MD,
    2. Judith G.M. Rosmalen, PhD,
    3. Alan Carson, MBChB, MPhil, MD,
    4. Joke M. Dijk, MD, PhD,
    5. Martijn Ekkel, MD,
    6. Glenn Nielsen, PhD,
    7. Jon Stone, MB ChB, FRCP, PhD* and
    8. Marina A.J. Tijssen, MD, PhD*
  1. Jeannette M. Gelauff, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Non-profit: 2019 and 2020 financial compensation for lectures to 2nd year medical students in Groningen University

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Allready listed in the manucript: Stichting MIND (previously: Fonds Psychische Gezondheid), with an unrestricted grant.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Judith G.M. Rosmalen, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaker fees of training institutes, always under 1000 USD and always paid to my employer and not to me personally

    Editorial Boards:

    1. (1) Journal of Psychosomatic Research, Advisory editor and special issue editor, 2012-current

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Handboek behandeling van somatisch onvoldoende verklaarde lichamelijke klachten, Lannoo Campus, 2017, less than 1000USD and paid to my employer and not to me personally

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. (1) I am seconded for one day a week to perform research at Dimence, a Dutch mental health care institute

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Nedap Healthcare: we develop an eHealth system for persistent physical symptoms in a collaboration between the UMCG and Nedap. We do not receive financial support but we both invest personnel in this development. Immediate family members: My husband is a scientist in a completely different field and has certainly obtained financial or material research support but this is not relevant at all to my work

    Research Support, Government Entities:

    1. (1) ZonMW Gender en Gezondheid – Algemene onderzoeksronde Sex and gender inequalities in medical trajectories of patients with common somatic symptoms. Grantnr 80-84900-98-189, PI, 2017-2021 (2) ZonMW OnderzoeksProgramma GGz - Middellanglopend Onderzoek. Master Your symptoms: personalized e-health for Self-management of somatic symptom disorder (MYSelf). Grantnr 60-63600-98-342, PI, 2017-2021 (3) H2020-SC1-2016-2017. Towards evidence-based tailored implementation strategies for eHealth (ImpleMentAll). Grantnr: 733025, local PI, 2016-2021 (4) EIT Health PERSPECTIVE. EIT Health - Personalised & patient centred healthcare. Grantnr 681282, local PI, 2016 (5) Innovatiefonds Zorgverzekeraars. Grip op onbegrepen klachten: een innovatief online persoonlijk patiëntsysteem voor geïntegreerde diagnostiek, verwijzing en behandeling van SOLK. Innovation Fund Health Insurances, the Netherlands, grant number 2619, 2013-2018. Immediate family members: My husband is a scientist in a completely different field and has certainly obtained financial or material research support but this is not relevant at all to my work

    Research Support, Academic Entities:

    1. My husband is a scientist in a completely different field and has certainly obtained financial or material research support but this is not relevant at all to my work

    Research Support, Foundations and Societies:

    1. My husband is a scientist in a completely different field and has certainly obtained financial or material research support but this is not relevant at all to my work

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Alan Carson, MBChB, MPhil, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Not for profit Harvard Concussion Forum travel and $1000 honorarium Alberta Psychiatric Association travel $1000 honorarium Neurodegeneration Poland travel $1000 honorarium

    Editorial Boards:

    1. Journal of Neurology Neurosurgery and Psychiatry

    Patents:

    1. NONE

    Publishing Royalties:

    1. Handbook of Neurology : Functional Neurological Disorders

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Unpaid treasurer Functional Neurological Disorders Society Provide indepedent testimony in Court on a range of neuropsychiatric topics 50% pursuer:50% defender

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIHR (UK) CODES trial Physio4FND

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Joke M. Dijk, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. A grant for an RCT studying botulinum toxin in functional jerky movement disorders from the

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Martijn Ekkel, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Glenn Nielsen, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) National Institute for Health Research (NIHR), HTA Project: 16/31/63, Chief Investigator, 3 years

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Jon Stone, MB ChB, FRCP, PhD* and
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaker honoraria from the Movement Disorders Society

    Editorial Boards:

    1. Editorial Board for Journal of Neurology, Neurosurgery and Psychiatry and Journal of Psychosomatic research

    Patents:

    1. NONE

    Publishing Royalties:

    1. Conversion Disorder (4 articles) - UptoDate since 2014

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Research Strategy Career Fellow with NHS Scotland

    Research Support, Academic Entities:

    1. runs a free self-help website for patients with functional disorders www.neurosymptoms.org.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Expert witness work in relation to personal injury and medical negligence.

  8. Marina A.J. Tijssen, MD, PhD*
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. AOP Orphan Pharmaceuticals AG travel and honorarium for scientific presentation.

    Editorial Boards:

    1. Frontiers of movement disorders editorial board 2014-nowClinical Movement Disorders editorial board 2015-nowBasal Ganglia journal 2016-2018

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Actelion for collaborative studies

    Research Support, Government Entities:

    1. the Netherlands Organisation for Health Research and Development ZonMW Topsubsidie (91218013)the European Fund for Regional Development from the European Union (01492947)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 2018-2021 the province of Friesland2017-2019 Dystonia medical research Foundation2015-2017 Healthy aging projects UMCG2015-2018Phelps Stichting. 2015-2017Prinses Beatrix kinderfonds UMCG2015-2017 wetenschapsfonds dystonie vereniging2016-2018Hersenstichting 2015-2017Fonds Psychische gezondheid

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (J.M.G., M.E., M.A.J.T.), Psychiatry (J.G.M.R.), and Internal Medicine (J.G.M.R.), University Medical Center Groningen, University of Groningen, the Netherlands; Centre for Clinical Brain Sciences (A.C., J.S.), University of Edinburgh, UK; Department of Neurology (J.M.D.), University of Amsterdam, Amsterdam University Medical Center, the Netherlands; and Neurosciences Research Centre (G.N.), Molecular and Clinical Sciences Research Institute, St George's University of London, UK.
  1. Correspondence
    Dr. Tijssen m.a.j.de.koning-tijssen{at}umcg.nl
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