Diet pattern and prodromal features of Parkinson disease
Citation Manager Formats
Make Comment
See Comments

Article Information
- Received November 18, 2019
- Accepted in final form April 28, 2020
- First Published August 19, 2020.
Article Versions
- Previous version (August 19, 2020 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Samantha Molsberry, PhD,
- Kjetil Bjornevik, MD, PhD,
- Katherine C. Hughes, ScD,
- Brian Healy, PhD,
- Michael Schwarzschild, MD, PhD and
- Alberto Ascherio, MD, DrPH
- Samantha Molsberry, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Kjetil Bjornevik, MD, PhD,
NONE
NONE
NONE
Frontiers in Neurology, Editorial board, 2017 - present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
The ALS Association
NONE
NONE
NONE
NONE
NONE
NONE
- Katherine C. Hughes, ScD,
NONE
NONE
NONE
NONE
NONE
NONE
UnitedHealth Group, Epidemiologist, 1 year
NONE
NONE
NONE
NONE
NONE
Department of Defense, grant number W81XWH-14-0131, graduate student/postdoctoral fellow, 2014-2018 Stock/Stock Options, Medical Equipment & Materials: UnitedHealth Group, 1 year
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Brian Healy, PhD,
NONE
NONE
NONE
(1) Statistical methods in medical research, editorial board, 2007-present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
(1) Merck Serono, S.A. (2) Novartis (3) Genzyme (4) Verily Life Sciences (5) Analysis Group
(1) NIH, 1R21NR018738, Biostatistician, 2020-present (2) NIH, P50MH115846-01A1, Biostatistician, 2019-present (3) NIH, 5UL1TR002541, Biostatistician, 2018-present (4) NIH, R01HL133149-03, Biostatistician, 2017-present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Michael Schwarzschild, MD, PhD and
(1) Michael J. Fox Foundation for Parkinson's Research SAB (New York, NY) [2017-2019] (2) Cure Parkinson's Trust foundation Linked Clinical Trials program SAB (London, UK) [∼2012- ] (3) Corticobasal Degeneration Solutions Foundation SAB (Stockholm, Sweden) (4) NINDS/Udall Center of the Brigham & Womens Hospital -- Internal Advisory Committee (Boston, MA) (5) Eli Lilly & Company (clinical trial DSMB service); 2018- (6) Prevail Therapeutics (clinical advisory board); 2018-2019 (7) Parkinson's Foundation (Genetics initiative advisory board); 2018- (8) X-linked Dystonia Parkinsonism Clinical Center; 2018- (9) Denali Therapeutics (clinical advisory board); 2019 (10) Chase Therapeutics (clinical development advisory board); 2019-2020
NONE
ÂDenali Therapeutics, seminar speaker (2019) All others are non-profit entities: ÂKrembil Conference (Toronto) lecture (2019) ÂXuanwu Hospital (Beijing) symposium lecture (2018) ÂThomas Jefferson University, grand rounds lecture (2018) ÂInternational Association of Parkinson's disease and Related Disorder, Melvin Yahr lecture (2018) ÂWorld Parkinson Congress, travel/honorarium (2006,2010,2013,2016,2019) ÂParkinson Study Group symposium/meeting Âfor Cure Parkinson's Trust program SAB mtg. (Windsor, UK; Grand Rapids, MI) Âfor Cure Parkinson's Trust program SAB mtg. (Grand Rapids, MI); (travel)
Journal of Adenosine and Caffeine Research, Editorial advisory board (2018-) Parkinsonism and Related Disorders, Editorial advisory board (2018-)
NONE
NONE
Massachusetts General Hospital (sole employer; non-profit)
(1) Harvard University (Parkinson's disease case reviews and epidemiology research); ∼2002-present (2) New Beta-Innovations, Inc (Hong Kong); 2016 (3) Eli Lilly & Company (clinical trial DSMB service); 2018- (4) Prevail Therapeutics, Inc (New York City); 2018-2019 (5) nQ Medical (Cambridge, MA); 2019 (6) Denali Therapeutics (Nice, France); 2019 (7) Chase Therapeutics (Washington, DC); 2019
NONE
NONE
NONE
NONE
ÂNIH R01 NS110879 (PI) 08/01/19  05/31/24 ÂNIH U01 NS107009 (a PI) 07/01/18 to 04/30/23 ÂNIH R13 NS111953 (PI) 04/01/19  03/31/22 ÂNIH U01 NS090259 (PI) 9/1/2015 to 6/30/2020 ÂNIH U13 NS103523 (PI) 07/01/17 - 06/30/18 ÂNIH R13 NS098746 (PI) 07/01/16 - 06/30/17 ÂDoD W81XWH-14-1-0131 (Collaborator [A. Ascherio, PI]) 05/15/14 - 05/14/15 ÂNIH R21 NS090246 (Co-Investigator [Xiqun Chen, PI]) 04/01/15 - 03/31/17 ÂNIH R01 (Collaborator [A. Ascherio, PI]) ÂNIH R13 NS090879 (PI) 09/22/14 - 08/31/15 ÂR21 NS084710 (dual PI: Schwarzschild) 7/1/13-6/30/15 NIH/NINDS ÂRole of urate in protecting mitochondrial function in the brain ÂK24 NS060991 (PI: Schwarzschild) 7/1/08-6/30/13 NIH/NINDS "Pursuing Puringergic Pathways to Clinical Trials for Parkinson's Disease" ÂDoD NETRP W81XWH-11-1-0150 (PI: Schwarzschild) 1/17/11  1/16/16 Dept of Defense / USAMRAA (ParkinsonÂs research program) "Protection by Purines in Toxin Models of Parkinson's Disease" ÂNIH/NINDS RO1 NS061858 (PI: A. Ascherio) 4/15/2009 - 3/31/2014 ÂUrate predictor Parkinson's Disease Risk and Progression Role: Collaborator
NONE
grant support via my institution (MGH) on projects for which I am the Principal Investigator: (1) Michael J. Fox Foundation (2) Parkinson's Foundation (3) Farmer Family Foundation
NONE
NONE
(1) Adenosine A2A receptor knockout mice, MGH (which receives payments from The Jackson Laboratory via licensing agreements); ∼2001-present (2) floxed urate oxidase mice, MGH; 2020-
NONE
NONE
NONE
- Alberto Ascherio, MD, DrPH
University of Rochester - Scientific Advisory Board of NIH-funded study "At-Home PD"
NONE
NorthShore University HealthSystem, Evanston IL, 2019. Honorarium for talk on neurodegenerative diseases. University of Oslo, Norway. Honorarium as PhD defense opponent.
1) Journal of Parkinson Disease, Editorial board
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NIH R01 NS073633; 2011-2017; Role: PI DoD W81XWH-14-1-0131; 2014-2019; Role: PI NIH R01 NS045893; 2013-2018; Role: PI NIH 1U01NS-90259; 2015-2020; Role: PI of subcontract NIH R01 NS089619-01A1; 2015-2020; Role: PI NIH R01 NS097723; 2016-2021; Role: Co-Investigator NIH R01 NS103891; 2018-2023; Role: PI CDMRP MS170116; 2018-2021; Role: PI
NONE
ALS Association; 2019-2020; Role: PI
NONE
NONE
NONE
NONE
NONE
NONE
- From the Population Health Sciences Program (S.M.), Harvard University, Cambridge; Departments of Nutrition (K.B., K.C.H., A.A.) and Epidemiology (A.A.), Harvard T.H. Chan School of Public Health; Partners Multiple Sclerosis Center (B.H.), Brigham and Women's Hospital; Department of Neurology (M.S.), Massachusetts General Hospital; and Channing Division of Network Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
- Correspondence
Dr. Molsberry sam306{at}mail.harvard.edu
Article usage
Cited By...
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
More Online
Dr. Jeffrey Allen and Dr. Nicholas Purcell
► Watch
Related Articles
Topics Discussed
Alert Me
Recommended articles
-
Article
Physical activity and prodromal features of Parkinson diseaseKatherine C. Hughes, Xiang Gao, Samantha Molsberry et al.Neurology, November 12, 2019 -
Article
Quality of Plant-Based Diet and Risk of Total, Ischemic, and Hemorrhagic StrokeMegu Y. Baden, Zhilei Shan, Fenglei Wang et al.Neurology, March 10, 2021 -
Article
Long-term intake of vegetables and fruits and subjective cognitive function in US menChangzheng Yuan, Elinor Fondell, Ambika Bhushan et al.Neurology, November 21, 2018 -
Research Article
Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and WomenTian-Shin Yeh, Changzheng Yuan, Alberto Ascherio et al.Neurology, July 28, 2021