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October 20, 2020; 95 (16) Clinical/Scientific NotesOpen Access

Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19

Dori Abel, Min Ye Shen, Zaynah Abid, Claire Hennigan, Alexis Boneparth, View ORCID ProfileEmily Happy Miller, Anne-Catrin Uhlemann, Danielle K. McBrian, Kiran Thakur, View ORCID ProfileWendy Silver, View ORCID ProfileJennifer M. Bain
First published August 26, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010652
Dori Abel
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Min Ye Shen
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Zaynah Abid
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Claire Hennigan
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Alexis Boneparth
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Emily Happy Miller
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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  • ORCID record for Emily Happy Miller
Anne-Catrin Uhlemann
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Danielle K. McBrian
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Kiran Thakur
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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Wendy Silver
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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  • ORCID record for Wendy Silver
Jennifer M. Bain
From the Columbia University Irving Medical Center (D.A., C.H., Z.A., A.B.), Department of Pediatrics, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (M.Y.S.), Department of Neurology, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (E.H.M., A.-C.U.), Department of Medicine, Division of Infectious Diseases, NewYork-Presbyterian Hospital; Columbia University Irving Medical Center (D.K.M., W.S., J.M.B.), Department of Neurology, Division of Child Neurology, NewYork-Presbyterian Hospital; and Columbia University Irving Medical Center (K.T.), Department of Neurology, NewYork-Presbyterian Hospital.
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  • ORCID record for Jennifer M. Bain
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Citation
Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19
Dori Abel, Min Ye Shen, Zaynah Abid, Claire Hennigan, Alexis Boneparth, Emily Happy Miller, Anne-Catrin Uhlemann, Danielle K. McBrian, Kiran Thakur, Wendy Silver, Jennifer M. Bain
Neurology Oct 2020, 95 (16) 745-748; DOI: 10.1212/WNL.0000000000010652

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    Figure Timeline of the patient's course

    ADC = apparent diffusion coefficient; CRP = C-reactive protein; DWI = diffusion-weighted imaging; G = glucose; HD = hospital day; IVIG = IV immunoglobulin; L = lymphocytes, M = monocytes; Lac = lactic acid; LP = lumbar puncture; M/E = meningitis/encephalitis; N = neutrophils; NT-proBNP = N -terminal-pro-B-type natriuretic peptide; P = protein; pg/mL = picogram/milliliter; RBC = red blood cell; SARS-CoV-2 RT-PCR = severe acute respiratory syndrome coronavirus 2 reverse transcription PCR; WBC = white blood cell. *Postplatelet transfusion.

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  • Author response: Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19
    • Dori N. Abel, Pediatric Resident Physician, Columbia University Irving Medical Center, Department of Pediatrics; NewYork-Presbyterian Hospital
    Submitted November 04, 2020
  • Reader response: Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19
    • Calixto Machado, Senior Professor and Researcher in Neurology, Corresponding Fellow of the American Academy of Neurology, Institute of Neurology and Neurosurgery (Havana, Cuba)
    Submitted October 27, 2020
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