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November 03, 2020; 95 (18) Article

Developmental neuroplasticity of the white matter connectome in children with perinatal stroke

Brandon T. Craig, Alicia Hilderley, Eli Kinney-Lang, Xiangyu Long, Helen L. Carlson, Adam Kirton
First published September 4, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010669
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Article Information

vol. 95 no. 18 e2476-e2486
DOI: 
https://doi.org/10.1212/WNL.0000000000010669
PubMed: 
32887781
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 6, 2019
  • Accepted in final form June 3, 2020
  • First Published September 4, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Brandon T. Craig, BSc,
    2. Alicia Hilderley, PhD,
    3. Eli Kinney-Lang, PhD,
    4. Xiangyu Long, PhD,
    5. Helen L. Carlson, PhD and
    6. Adam Kirton, MD
  1. Brandon T. Craig, BSc,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Alicia Hilderley, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Eli Kinney-Lang, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. 1.) In December 2019, I founded a 'start-up' limited liability company (Neural Matrix Entertainment LLC.) focused on brain-computer interfaces and gaming. This company has no investors, no developments and currently is in the incubation phase. There has been no compensation, investment or financial contributions to the company in any form.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Xiangyu Long, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Helen L. Carlson, PhD and
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Adam Kirton, MD
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 2016 CHILD-BRIGHT: Child Health Initiatives Limiting Disability - Brain Research Improving Growth and Health Trajectories CIHR Strategic Patient Oriented Research (SPOR) in Chronic Disease 5 years, $12,450,000 (Mar 2016-Feb 2021) PI: Majnemer A, Cohen E, Goldowitz D, Gorter J, Kirton A, Lach L, Marelli A, McGrath P, Miller SP; CI: Florence D, Gavin F, Kitch T, Major-Cook N, O'Donnell M, Thomson D 2016 Emancipation of Children with Severe Quadriplegic Cerebral Palsy Using Brain-Computer Interfaces (EQUIP) Department of Pediatrics Innovation Award 1 year, $22000 CDN (Mar 2016 – Feb 2017) PI: Kirton A; CI: Burkholder L, Zewdie E, Emory C, Brunton L, Beckers K, Betuzzi C, Hodge J 2016 Enhancing Medicosurgical Skill Learning with Transcranial Direct-Current Stimulation OHMES Health Science and Medical Education Research and Innovation Grant 1 year, $10000 CDN (Mar 2016- Feb 2017) PI: Kirton A, Ciechanski P; CI: Cheng A, Lopuchinsky S 2015 The Alberta Perinatal Stroke Program: Neuromodulation to Optimize Outcomes CIHR Foundations Award 7 years, $2,823,521 CDN (2015-2022) PI: Kirton A, Collaborators (23) 2015 Mind control for severe hemiparesis in children: Brain computer interface development in perinatal stroke Heart and Stroke Foundation of Alberta Seed Grant 1 year, $45000 CDN (Sep 2015 – Aug 2016) PI: Kirton A; CI: Dukelow S, Zewdie E 2014 Imaging the sensory network in children with perinatal stroke and cerebral palsy Robertson Fund for Cerebral Palsy, Hotchkiss Brain Institute 1 year, $30000 CDN (Sep 2014 – Aug 2015) PI: Kirton A, Dukelow S 2013 BDNF genetics of neuroplasticity in cerebral palsy Robertson Fund for Cerebral Palsy, Hotchkiss Brain Institute 1 year, $30000 CDN (July 2013 – June 2014) PI: Kirton A, Hill M 2013 HICCUP: Healthy Infants and Children Clinical Research Program Innovation Award, ACH Department of Pediatrics 1 year (Mar 2013-Feb 2014), $25000 PI: Kirton A; CI: Johnson D, Herpinger L, Denys J MAJOR RESEARCH FUNDING AWARDED – PRINCIPAL INVESTIGATOR cont 2012 The Alberta Perinatal Stroke Project Alberta Innovates Health Solutions Collaborative Research and Innovation Opportunities Project 3 years (2013-2016), $750000 PI: Kirton A; Co-leads: Yager J, Andersen J, Collaborators: Brooks B, Dukelow S, Kosior J, Hagel B, Buchhalter J, Nettel-Aguirre A, O’Grady K, Hill MD. 2012 Enhancement of developmental motor plasticity in perinatal stroke with TDCS Heart and Stroke Foundation, 3 years (2012-2015), $270000. PI: Kirton A; CI: Hill MD, Fehlings D, Andersen J, Goodyear B, Dukelow S, Beaulieu C, Dewey D, Chen R, Majnemer A

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Occasional medicolegal expert testimony for plaintiffs or defendants.

  1. From the Calgary Pediatric Stroke Program (B.T.C., A.H., E.K.-L., H.L.C., A.K.); and Hotchkiss Brain Institute (B.T.C., A.H., E.K.-L., X.L., H.L.C., A.K.), Alberta Children's Hospital Research Institute (B.T.C., A.H., E.K.-L., X.L., H.L.C., A.K.), and Departments of Pediatrics (H.L.C., A.K.) and Clinical Neuroscience (A.K.), Cumming School of Medicine, University of Calgary, Canada.
  1. Correspondence
    Dr. Kirton Adam.kirton{at}albertahealthservices.ca
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