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December 15, 2020; 95 (24) Article

Apathy and risk of probable incident dementia among community-dwelling older adults

Meredith A. Bock, Amber Bahorik, Willa D. Brenowitz, Kristine Yaffe
First published October 14, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010951
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Article Information

vol. 95 no. 24 e3280-e3287
DOI: 
https://doi.org/10.1212/WNL.0000000000010951
PubMed: 
33055276
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 29, 2020
  • Accepted in final form August 12, 2020
  • First Published October 14, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Meredith A. Bock, MD,
    2. Amber Bahorik, PhD,
    3. Willa D. Brenowitz, PhD, MPH and
    4. Kristine Yaffe, MD
  1. Meredith A. Bock, MD,
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number TL1 TR000144

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Amber Bahorik, PhD,
    3. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Willa D. Brenowitz, PhD, MPH and
    4. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIA T32AG049663, trainee, 2017-2019NIH/NIA K01AG062722, PI, 2019-currentUCSF Claude D. Pepper Older Americans Independence Center funded by National Institute on Aging, P30 AG044281, REC scholar, 2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association, AARF-18-565846

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Kristine Yaffe, MD
    5. Scientific Advisory Boards:

    1. 1)DSMB for Eli Lilly2)DSMB for NIH sponsored trial3)Beeson Scientific Advisory Board4)Global Council on Brain Health 5)Board member of Alector

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry-Editorial Board Member 2014-, Journal of Prevention of Alzheimer?s Disease- Editorial Board Member 2017-, Alzheimer?s & Dementia: Translational Research & Clinical Interventions- Editorial Board Member 2018-, Translational Neurodegeneration

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIA K24 AG031155 06/13-11/20PI:YaffePredictors of cognitive aging across the lifecourse2. Sierra-Pacific VISN 10/09-09/23DirectorMental Illness Research, Educational and Clinical Center Psychiatric Fellowship3. Sierra-Pacific VISN 10/09-09/23PI of Dementia Research at SFVAMental Illness Research, Educational and Clinical Center4. Department of Defense W81XWH-16-1-050708/16-08/20PI:YaffeRisk and Resiliency for Dementia: Comparison of Male and Female Veterans5. NIA RF1 AG05444305/17-04/21Multiple PI: Yaffe/ Zeki-Al Hazzouri Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment6. NIA R01 AG05750809/17-11/21Multiple PI: Yaffe/LarsonSystematic Multidomain Alzheimers Risk Reduction Trial (SMARRT)7. NIA R01 AG05407309/17-05/22Multiple PI: Yaffe/O?Bryant/TogaHealth Disparities in Alzheimer?s Disease and Mild Cognitive Impairment among Mexican Americans8. NIA R01 AG05853706/18-05/21Multiple PI: Yaffe/O?BryantAn Alzheimer?s Blood Test for Primary Care9. Department of Army W81XWH-18-1-069209/18-09/21Multiple PI: Yaffe/PlassmanGenetics, comorbidities, and ethnicity: Effects of TBI on Dementia 10. NIA R01 AG06388709/19-05/23Multiple PI: Yaffe/SidneyLifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer?s and Dementia Prevention11. NIA R01 AG06613709/19-06/24Multiple PI: Yaffe/O?BryantSleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic Whites (HABLE-Dormir) 12. Department of Defense W81XWH-19-1-066910/19-09/23Multiple PI: Yaffe/Gardner/TosunNeuroimaging Endophenotypes & Predictors Post-TBI Dementia in A Nationwide Cohort of Veterans13. Department of Defense/VA W81XWH-18-PH/TBIRP-LIMBIC I01CX002096 10/19-09/24PI: YaffeLong-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiological Study

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists2) Alzheimer?s Drug Discovery FoundationConnection Between Depressive Symptoms and Dementia:When Best to Intervene?

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (M.A.B., K.Y.), Psychiatry (A.B., W.D.B., K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; and San Francisco Veterans Affairs Medical Center (K.Y.), CA.
  1. Correspondence
    Dr. Bock Meredith.Bock{at}ucsf.edu
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