Preserving stroke care during the COVID-19 pandemic
Potential issues and solutions
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Article Information
- Received April 8, 2020
- Accepted in final form April 29, 2020
- First Published May 8, 2020.
Article Versions
- Previous version (May 8, 2020 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Enrique C. Leira, MD, MS,
- Andrew N. Russman, DO,
- José Biller, MD,
- Devin L. Brown, MD,
- Cheryl D. Bushnell, MD,
- Valeria Caso, MD, PhD,
- Angel Chamorro, MD, PhD,
- Claire J. Creutzfeldt, MD,
- Salvador Cruz-Flores, MD, MPH,
- Mitchell S.V. Elkind, MD, MS,
- Pierre Fayad, MD,
- Michael T. Froehler, MD, PhD,
- Larry B. Goldstein, MD,
- Nicole R. Gonzales, MD,
- Brian Kaskie, PhD,
- Pooja Khatri, MD, MSc,
- Sarah Livesay, DNP, ARNP,
- David S. Liebeskind, MD,
- Jennifer J. Majersik, MD,
- Asma M. Moheet, MD, MHDS,
- Jose G. Romano, MD,
- Nerses Sanossian, MD,
- Lauren H. Sansing, MD, MS,
- Brian Silver, MD,
- Alexis N. Simpkins, MD, PhD, MS,
- Wade Smith, MD, PhD,
- David L. Tirschwell, MD, MSc,
- David Z. Wang, DO,
- Dileep R. Yavagal, MD and
- Bradford B. Worrall, MD, MSc
- Enrique C. Leira, MD, MS,
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US patent Application N0 16/783,003 pending: SYSTEMS, METHODS AND DEVICES FOR LOW FREQUENCY VIBRATION AND SYNERGISTIC THROMBOLYTIC INFUSION ON SUBJECTS WITH ISCHEMIC STROKE OR IN NEED OF THROMBOLYSIS (filed by University of Iowa. EC Leira inventor) Not relevant to this manuscript
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NIH-NINDS U10NS086521-01 ÂThe University of Iowa's Statewide Stroke Research Network Role: Principal Investigator. 10/2013-ONGOING R21 NS104579
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- Andrew N. Russman, DO,
(1) Portola Pharmaceuticals
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(1)Boston Scientific Corp.
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- José Biller, MD,
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Editor of Journal of Stroke and Cerebrovascular DiseasesStroke Editorial Board Member of Up-To-Date
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Practical Neurology 5th Edition, Wolters Kluwers, 2017 Localization in Clinical Neurology 7th Edition, Wolters Kluwers, 2017 The Hospital Neurologist, McGraw Hill, 2017 The Neurologic Examination 7th Edition, McGraw Hill, 2017 Primer on Cerebrovascular Diseases 2nd Edition, Elsevier, 2017 Uncommon Causes of Stroke 3rd Edition, Cambridge Medicine 2018
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- Devin L. Brown, MD,
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University of Washington; American Heart Association
Neurology, editorial board member, 2008-present
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NHLBI, R01HL123379, M-PI, 04/17/15 - 03/31/19 NHLBI, R01HL126700, M-PI, 12/15/15 - 11/30/19 NINDS, U24NS107214, M-PI, 08/14/18 - 07/31/23 NINDS, U01NS099043, M-PI, 08/15/18 - 07/31/24 NIMHD, R01MD011516, Co-I, 07/14/17 - 02/28/21 NINDS, R01NS038916, Co-I, 02/01/09 - 03/31/24
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- Cheryl D. Bushnell, MD,
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Stroke in Women, Henry Stewart Talks, 2007-2020 Neurological Diseases and Pregnancy, Oxford University, 2019- present
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Patient Centered Outcomes Research Institute PCA-1403-14532, COMprehensive Post-Acute Stroke Services pragmatic trial; role: co-PI, 3 years Affordability and Efficiency for COMprehensive Post-Acute Stroke Services (COMPASS); AHRQ R01HS025723-01, role: co-PI
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1) Care Directions, LLC, No compensation since startup.
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- Valeria Caso, MD, PhD,
Respect ESUS Bayer SPI
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Daichi-Sankyo BI Servier
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Daichi-Sankyo BI Servier bms
speakerÂs bureau of Boehringer Ingelheim, Bayer, daichi- Sankyo, Ever Pharma
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- Angel Chamorro, MD, PhD,
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ÂPharmaceutical composition for neuroprotective treatment in patients with ictus comprising citicoline and uric acid Nº of patent: No. 2012-0502476 Country of inscription: Germany, UK, France, Italy
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Dr Chamorro owns stock in FreeOx Biotech SL. This SME is committed to test the therapeutic value of the administration of uric acid in patients with acute ischemic stroke
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- Claire J. Creutzfeldt, MD,
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Career Development Award NINDS K23 NS099421-01A1 07/2018-07/2022
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Cambia Health Foundation's Sojourn Scholars Program
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- Salvador Cruz-Flores, MD, MPH,
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AAN: funding for travel
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NovoNordisk CEC member Duke University CEC member Galapagos CEC member
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- Mitchell S.V. Elkind, MD, MS,
Vascular Dynamics, interventional treatment for hypertension (2018-2019)
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(1) Stroke, Editor of International Stroke Early Career and Training Section, published by AHA (2017-2019)
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UpToDate, 2015-2020, chapters on cryptogenic stroke and hemicraniectomy for acute stroke
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Abbott, consulting regarding cryptogenic stroke (2017-2018)
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(1) American Heart Association National Board of Directors (2014-2022); (2) American Heart Association Founders Affiliate Board of Directors(2008-2016); (2) American Heart Association NY City Board of Directors (2011-2017)
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(1) BMS-Pfizer Alliance, provides drug in kind for support of clinical trial of aspirin vs apixaban for cryptogenic stroke; (2) Roche, provides lab support for support of clinical trial of aspirin vs apixaban for cryptogenic stroke and stroke (2014-2016)
(1) NIH/NINDS R01 29993, PI, 2007-2020(2) NIH/NINDS U01 NS095869, PI, ARCADIA, 2017-2022
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- Pierre Fayad, MD,
(1) Medtronic (2) Portola
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- Michael T. Froehler, MD, PhD,
1. Medtronic 2. Genentech 3. Viz.ai 4. Balt USA 5.Stryker 6. Cerenovus 7. Corindus 8. EndoPhys
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1. Medtronic 2. Genentech 3. Viz.ai 4. Balt USA 5.Stryker 6. Cerenovus 7. Corindus 8. EndoPhys
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1. Stryker 2. Medtronic 3. Microvention 4. Penumbra 5. EndoPhys 6. Genentech
NIH - NINDS. The grant number(s) should not be listed, as this funding is irrelevant to the current work.
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- Larry B. Goldstein, MD,
Comercial - Shin Poong Pharmaceuticals
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Comercial - Shin Poong Pharmaceuticals
1. Stroke, Editorial Board, 2002- 2. Neurology, Editorial Board, 2003 Â 3. Cerebrovascular Diseases, Editorial Board, 2004 - (Associate Editor 2012-) 4. Journal of Stroke and Cerebrovascular Disease (Editorial Board) 5. Cardiology Today, Editorial Board, 2011- No compensation
Test for amylin deposition.
1. Screening for Asymptomatic Carotid Stenosis, Up-to-Date, 2007- 2. Use and Utility of Stroke Scales and Grading Sysytems, Up-to- Date, 2005-
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Comercial- Shin Poong Pharmaceuticals
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1. NIH, Stroke Hospitalization in Elderly with Medicare, Consultant 2. NIH, Small Vessel Disease Biomarkers in a Longitudinally-Followed
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American Heart Association - Post-acute care services and outcomes among elderly stroke patients
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- Nicole R. Gonzales, MD,
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Editorial Board, Neurology
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Carotid revascularization and medical management for asymptomatic carotid stenosis trial (CREST-2) NINDS U01 NS080168 (Brott, Meschia, Lal, Howard) 3/1/2015 - 2/28/2021 Role: Local PI Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study Blind Adjudicator, Vascular Neurologist 11/1/17-11/1/21 Role: Local Co-I
Developing a Biochemical Test to Differentiate Cerebral Amyloid Angiopathy-Intracerebral Hemorrhage from Hypertensive Hemorrhage (Gonzales, Pritzkow Co-PIs) 3/1/2019-2/28/2020 IGNITE Award Role: Co-PI
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- Brian Kaskie, PhD,
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- Pooja Khatri, MD, MSc,
(1) Diamedica (SAB) (2) Lumosa (company medical representative on DSMB)
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Stroke, Associate Editor, 2020-current
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UpToDate, Inc -- ongoing update to Stroke article
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Lumosa
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1) Cerenovus (IIS grant) 2) Bayer (National PI effort) 3) Nervive (NIH SBIR grant co-I)
1. NIH/NINDS U25, StrokeNET RCC PI 2. NIH/NINDS U01, StrokeNET NCC MPI 3. NIH/NINDS R01, APRISE MPI
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- Sarah Livesay, DNP, ARNP,
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Stryker NV, Speaker Fees
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StrokeChallenges, Lombardi Hill LLC
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Secretary, Neurocritical Care Society
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- David S. Liebeskind, MD,
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Consultant as Imaging Core Lab to Cerenovus, Genentech, Medtronic, Stryker
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- Jennifer J. Majersik, MD,
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(1) Neurology, Editorial Board Member, 2015-present (2) Stroke, Associate Editor, 2020-present (3) UpToDate, Reviewer, 2018-present
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(1) Commericial entity, Foldax, Inc
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(1) NIH/NINDS, 1U24NS107228 - UT StrokeNet, Principal Investigator, 2018-23 (2) NIH/NINDS, 1U24NS107156 - UR NEXT, Mentor, 2018-23 (3) NIH/NICHD, 1R03HD091432 - Co-Investigator, 2017-19
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- Asma M. Moheet, MD, MHDS,
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Neurocritical Care, Editorial Board member, 3 years.
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InTouch Health, telemedicine neurointensivist, 0 years Stock/Stock Options, Medical Equipment & Materials: (1)GE, 0 (2)Moderna, 0 (3)Teladoc Health, 0
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- Jose G. Romano, MD,
1) Genentech: for role as member of the independent data monitoring committee for the TIMELESS trial. 2) Genentech: for role as member of the Steering Committee of the Potential for rtPA to Improve Stroke with Mild Symptoms (PRISMS) Study. 2) Vycor/NovaVision: for role as member of the Scientific Advisory Board.
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1) Genentech. Principal Investigator Mild and Rapidly Improving Stroke Study (MaRISS) (M1301087). 12/14/11 - 10/31/20. 2) Bristol Myers Squibb (M1800108). Disparities in Stroke Outcomes in patients with Atrial Fibrillation (FLiPER AF). Sub-Investigator (PI T. Rundek). 02/01/17- 01/31/20.
1) National Institute on Minority Health and Health Disparities. Transition of Care Stroke Disparity Study (TCSD-S). R01MD012467. Principal Investigator (MPI, co-PI R.L. Sacco, T. Rundek). September 26, 2017- June 30, 2022. 2) National Institute of Neurological Disorders and Stroke. Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD). R01NS084288. Principal Investigator (MPI, co-PI S. Prabhakaran, D.S. Liebeskind). March 1, 2014 - February 28, 2021 (NCE). 3) National Institute of Neurological Disorders and Stroke. Florida Regional Coordinating Center for NINDS Stroke Trials Network. U24NS107267. Principal Investigator (MPI, co-PI R.L. Sacco). August 1, 2018-July 31, 2023.
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Vycor/NovaVision
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- Nerses Sanossian, MD,
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- Lauren H. Sansing, MD, MS,
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NIH/NINDS, U01NS113445, PI, 2019-2022 NIH/NINDS R01NS095993, PI, 2016-2021 NIH/NINDS R01NS097728, PI, 2016-2021
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American Heart Association, 19EIA34770133, PI, 2019-2024
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- Brian Silver, MD,
1. National Institutes of Health StrokeNet study section 2. Women's Health Initiative
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Transcranial magentic stimulation helmet
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Best Doctors, Inc.
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Medicolegal expert review, 2005-present
- Alexis N. Simpkins, MD, PhD, MS,
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eNeurologicalSci, Assistant Editor, 2
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- Wade Smith, MD, PhD,
(1) DAWN and ATLAS DMSB- Stryker
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Cranial Accelerometry and the detection of large vessel stroke
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(1) U24NS107229, CO-PI, 2018-2023 Stock/Stock Options, Medical Equipment & Materials: Founder, MindRhythm, Inc
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- David L. Tirschwell, MD, MSc,
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1) Abbott, speaker honoraria, unrelated to topic
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1) Abbott, consultant
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Abbott Biogen
NINDS, U01 NS095869, co-PI, 2017-21 NIH, 1D43TW009137, co-PI, 2019-24 CDC/WA DOH, N21529, consultant, 2019-2020
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- David Z. Wang, DO,
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Editorial Board member: Stroke and Vascular Neurology, Journal of Stroke and Cerebrovascular Disease
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- Dileep R. Yavagal, MD and
Commercial or non-profit entity: Poseydon, Neural analytics
1. Medtronic, Inc 2. Cerenovus 3. Rapid Medical 4. Vascular Dynamics
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1. Interventional Neurology, Editorial advisory Board member 2.Frontiers in Endovascular Neurology, Associate Editor, 2010 till date
Continuous Automated Suction Device. This is a endotracheal suction and intubation device for intubated patient on a ventilator.
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Consultant to: 1. Medtronic 2. Cerenovus 3. Rapid Medical 4. Neuralanalytics 5. Vascular Dynamics 6. Deck Therapeutics 7. Inneuroco, Inc 8. GLG consulting 9. Guidepoint consulting 10. Mosaic consulting 11. Poseydon Medical, LLC. 12. Neurosave 13. Magellan Research Group, LLC.
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Clinical procedure/imaging study: Stroke Mechanical Thrombectomy
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a. Miami Clinical Translational Science Institute (CTSI) Pilot Study Award for study titled: Time Window of Intracarotid Mesenchymal Stem Cell Therapy in a Large Animal Model of Stroke. This grant is awarded by the NIH funded CTSI program at the University of Miami Miller School of Medicine. ,PI, 1/2013- 12/2013: b.James & Esther King Biomedical Research Program Grant for the study titled Intra-arterial Mesenchymal Stem Cell Delivery in a Canine Model of Acute Ischemic Stroke: PI,2011-2014: This is a competitive grant for $500,000.00 c. James & Esther King Biomedical Research Program Shared Instrumentation Grant (SIG), 2010 Hare, Heldman and Yavagal: Co-PI, 2010. This is a competitive grant for $1000,000.00
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1. Goldberg Segala: 2018-2019 2.Eadie Hill Trial Lawyers, LLC: 2018, 2019 3. Rourke and Blumenthal: 2019, 4. Salta Mongeluzzi Barrett & Ben 2019 5. Nelson Mullins Riley & Scarborogh, 2019 6. Arnold Torado Welch & Foliona Co., LPA, 2019 7. Deutsch & Blumberg, PA, 2019, 2020 6. Colson Hicks Eidson, 2019 7. Carnival Cruise Lines, 2019
- Bradford B. Worrall, MD, MSc
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Neurology: Associate Editor 1 July 2009 - September 2015; Deputy Editor October 2015 - present
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Chapter Author for Merritt's Neurology editions 10, 11, and 12.
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AegisCN, LLC/Duke Clinical Research Institute - Serving as a site for phase II clinical trial titled
NINDS/NIH Â U24 NS107222 (co-Principal Investigator) 2018- 2023 NIH/NCATS Â U54 TR002586 (co-Principal Investigator KL2) 2018-2023 NINDS/NIH - R21 NS106480 (Principal Investigator) 2018- 2020 NINDS/NIH - R01 NS 069763 (co-investigator) 2010-2017
University of Virginia - CENTERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Principal Investigator 10/13-4/17
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- From the Departments of Neurology, Neurosurgery & Epidemiology (E.C.L.), University of Iowa, Iowa City, IA; Cerebrovascular Center (A.N.R.), Cleveland Clinic, OH; Department of Neurology (J.B.), Loyola University Chicago, Maywood, IL; Department of Neurology (D.L.B.), University of Michigan, Ann Arbor, MI; Department of Neurology (C.D.B.), Wake Forest School of Medicine, Winston-Salem, NC; Stroke Unit (V.C.), University of Perugia, Italy; Department of Neurology (A.C.), Hospital Clinic, Barcelona, Spain; Department of Neurology (C.J.C., D.L.T.), University of Washington, Seattle, WA; Department of Neurology (S.C.-F.), Texas Tech University, El Paso, TX; Departments of Neurology & Epidemiology (M.S.V.E.), Columbia University, New York, NY; Department of Neurological Sciences (P.F.), University of Nebraska, Omaha, NE; Department of Neurology & Neurosurgery (M.T.F.), Vanderbilt University, Nashville, TN; Department of Neurology (L.B.G.), University of Kentucky, Lexington, KY; Department of Neurology (N.R.G.), McGovern Medical School at UTHealth, Houston, TX; Department of Health Management and Policy (B.K.), University of Iowa, Iowa City, IA; Department of Neurology (P.K.), University of Cincinnati, OH; Department of Adult Health & Gerontology Nursing (S.L.), Rush University, Chicago, IL; Department of Neurology (D.S.L.), UCLA; Department of Neurology (J.J.M.), University of Utah, Salt Lake City, UT; Neurocritical Care, OhioHealth Riverside Methodist Hospital (A.M.M.), Columbus, OH; Department of Neurology (J.G.R.), University of Miami, FL; Department of Neurology (N.S.), University Southern California, Los Angeles, CA; Department of Neurology (L.H.S.), Yale School of Medicine, New Haven, CT; Department of Neurology (B.S.), University of Massachusetts, Worcester, MA; Department of Neurology (A.N.S.), University of Florida, Gainesville, FL; Department of Neurology (W.S.), UCSF; Department of Neurology (D.Z.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology & Neurosurgery (D.R.Y.), University of Miami, FL; and Department of Neurology (B.B.W.), University of Virginia, Charlottesville, VA.
- Correspondence
Dr. Leiraenrique-leira{at}uiowa.edu
Article usage
Cited By...
Letters: Rapid online correspondence
- Author response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Enrique Leira, MD, MS, University of Iowa
- Andrew N. Russman, DO, Cleveland Clinic Foundation
- Bradford B. Worrall, MD, University of Virginia
Submitted July 28, 2020 - Author response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Enrique Leira, MD, MS, University of Iowa
- Andrew N. Russman, DO, Cleveland Clinic Foundation
- Bradford B. Worrall, MD, University of Virginia
Submitted July 24, 2020 - Reader response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Vaitsa Giannouli, PhD, Institute of Neurobiology, Bulgarian Academy of Sciences
- Nikolaos Syrmos, PhD, School of Medicine, Aristotle University of Thessaloniki
Submitted July 23, 2020 - Reader response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Khichar Shubhakaran, Senior Professor and Head of Department of Neurology, Dr. S.N. Medical College (Jodhpur, India)
Submitted July 21, 2020 - Author response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Enrique Leira, Neurlogist, University of Iowa
- Andrew N. Russman, DO, Cleveland Clinic Foundation
- Bradford B. Worrall, MD, University of Virginia
Submitted June 10, 2020 - Reader response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Marcele Schettini, Neurologist, Hospital das Clínicas, University of São Paulo, Brazil
- Adalberto Studart, Neurologist, Hospital das Clínicas, University of São Paulo, Brazil
- Adriana Bastos Conforto, Neurologist - PhD, Hospital das Clínicas, University of São Paulo, Brazil
Submitted June 01, 2020 - Author response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Enrique Leira, MD, MS, University of Iowa
- Andrew N. Russman, DO, Cleveland Clinic Foundation
- Mitchell S.V. Elkind, MD, MS, MPhil, Columbia University
- Bradford B. Worrall, MD, University of Virginia
Submitted May 19, 2020 - Reader response: Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions
- Calixto Machado, Neurologist, AAN Corresponding Fellow, Insttitute of Neurology and Neurosurgery (Havana, Cuba)
Submitted May 10, 2020
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