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August 04, 2020; 95 (5) Clinical/Scientific Notes

COVID-19 presenting with ophthalmoparesis from cranial nerve palsy

Marc Dinkin, Virginia Gao, Joshua Kahan, Sarah Bobker, Marialaura Simonetto, Paul Wechsler, Jasmin Harpe, Christine Greer, Gregory Mints, Gayle Salama, Apostolos John Tsiouris, Dana Leifer
First published May 1, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009700
Marc Dinkin
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Virginia Gao
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Joshua Kahan
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Sarah Bobker
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Marialaura Simonetto
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Paul Wechsler
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Jasmin Harpe
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Christine Greer
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Gregory Mints
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Gayle Salama
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Apostolos John Tsiouris
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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Dana Leifer
From the Department of Neurology (M.D., V.G., J.K., S.B., M.S., P.W., J.H., D.L.), Department of Ophthalmology (M.D., C.G.), Department of Medicine (G.M.) and Department of Radiology (G.S., A.J.T.), Weill Cornell Medical College, New York.
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COVID-19 presenting with ophthalmoparesis from cranial nerve palsy
Marc Dinkin, Virginia Gao, Joshua Kahan, Sarah Bobker, Marialaura Simonetto, Paul Wechsler, Jasmin Harpe, Christine Greer, Gregory Mints, Gayle Salama, Apostolos John Tsiouris, Dana Leifer
Neurology Aug 2020, 95 (5) 221-223; DOI: 10.1212/WNL.0000000000009700

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Neurologic complications of COVID-19 are not well described. We report 2 patients who were diagnosed with COVID-19 after presenting with diplopia and ophthalmoparesis.

Case 1

A 36-year-old man with a history of infantile strabismus presented with left ptosis, diplopia, and bilateral distal leg paresthesias. He reported subjective fever, cough, and myalgias which had developed 4 days earlier and resolved before presentation. Examination was notable for left mydriasis, mild ptosis, and limited depression and adduction, consistent with a partial left oculomotor palsy. Abduction was limited bilaterally consistent with bilateral abducens palsies (figure, A). Lower extremity hyporeflexia and hypesthesia, and gait ataxia were noted. WBC was 2.9 × 103/µL with an absolute lymphocyte count of 0.9 × 103/µL. Nasal swab for SARS-CoV-2 PCR was positive. MRI revealed enhancement, T2-hyperintensity, and enlargement of the left oculomotor nerve (figure, B–D). Chest radiograph was unremarkable. The next day, there was worsening left ptosis, complete loss of depression and horizontal eye movements on the left and loss of abduction on the right. The patient received IV immunoglobulin (2g/kg over 3 days) to treat presumed Miller Fisher syndrome and hydroxychloroquine for COVID-19 (600 mg twice a day for 1 day, followed by 400 mg daily for 4 days). Deficits improved partially before discharge 3 days after admission. A ganglioside antibody panel was negative.

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Figure Eye movements and radiologic findings in 2 patients with COVID-19 and ophthalmoparesis

Motility examination of patient 1 (A) revealed limitation of left eye adduction (A.a) and depression (A.d). A subtle left eye hypertropia was observed in primary gaze (A.b), which worsened in left gaze (A.c). Enhancement of the left oculomotor nerve (arrows) can be seen on coronal (B) and axial (C) T1 fat-saturated postcontrast MRI. Enlargement and hyperintense signal of the left oculomotor nerve is demonstrated (arrows) on axial T2 fat-saturated MRI sequence (D). Motility examination of patient 2 (E) revealed 40% abduction of the right eye consistent with a right abducens palsy (E.a), and an esotropia in primary gaze (E.b). Enhancement of the perineural sheaths without involvement of the optic nerve substance was seen in the right eye (arrows) and left eyes (arrowhead) on axial T1 fat-saturated postcontrast MR sequence (F). Enhancement of Tenon's capsule was seen OD (arrows) and OS (arrowhead) on axial T1 fat-saturated postcontrast MRI (G). Chest x-ray revealed multifocal pneumonia (H).

Case 2

A 71-year-old woman with hypertension presented with painless diplopia on waking 2 days before and could not abduct her right eye (figure, E). Visual acuity, pupils, and funduscopy were normal. She reported cough and fever for several days. She was sent to the emergency department, where she was febrile and hypoxemic. WBC was 9.2 × 103/µL with an absolute lymphocyte count of 0.5 × 103/µL. Lumbar puncture was normal with opening pressure of 16 cm H2O. MRI showed enhancement of the optic nerve sheaths and posterior Tenon capsules (figure, F and G). Chest radiograph revealed bilateral airspace opacities (figure H), and nasal PCR for SARS-CoV-2 was positive. Her COVID-19 pneumonia was treated with hydroxychloroquine (dosing as above). Her abduction palsy did not improve significantly before discharge on room air after a 6-day admission. She reported gradual improvement of diplopia when contacted by phone 2 weeks after discharge.

Discussion

We describe 2 patients who developed cranial neuropathies within days of respiratory symptoms related to SARS-CoV-2 infection and were found to have abnormal perineural or cranial nerve findings on MRI. To reduce the risk of transmission, workup was limited to the essential studies needed to determine management.

In a retrospective review of 214 patients with COVID-19 in Wuhan, China, 36.5% had neurologic symptoms,1 which were more common in patients with severe disease. Most were nonspecific symptoms common in viral infections such as headache and dizziness, but 5.7% presented with acute cerebrovascular disease. The occurrence of hypogeusia and anosmia suggests olfactory bulb involvement, which has been proposed as a mechanism of entry into the nervous system.2 COVID-19 encephalitis with positive SARS-CoV-2 PCR in the CSF3 and acute necrotizing brainstem encephalopathy4 have been reported. CNS manifestations were more prevalent in patients with lymphopenia,1 as seen in our patients. CNS entry of SARS-CoV-2 may depend on viral interaction with membrane-bound ACE2 receptor,5 which is expressed not only in nasal and oral mucosa but also in the nervous system,2 and SARS-CoV-2 appears to have a 10- to 20-fold higher affinity than SARS-CoV for the ACE2 receptor.5 Notably, neither patient had a history of ACE inhibitor use.

The combination of ophthalmoparesis, leg paresthesia, and areflexia in our first case suggested an acute demyelinating inflammatory polyneuropathy secondary to a virus-mediated immune response, similar to other reports.6 However, the occurrence of neurologic symptoms within a few days of disease onset led to consideration of direct infection. In our second case, although radiologic evidence of abducens nerve involvement was lacking, the presence of optic nerve sheath enhancement of the involved eye could reflect viral leptomeningeal invasion, although these findings are nonspecific.7 Given her risk factors and the painless nature of the diplopia, the differential includes an ischemic process. In both cases, neurologic symptoms could be unrelated to SARS-CoV-2 infection. Nonetheless, in the setting of the COVID-19 pandemic, the occurrence of cranial neuropathies should prompt consideration of SARS-CoV-2 infection in patients with even mild symptoms and signs of COVID-19. Hydroxychloroquine was used in both cases per institutional practice, although whether clinical benefit was conferred is not known. Further studies are needed to understand the natural history and prognostic significance of cranial neuropathies in SARS-CoV-2 infection and to determine the best treatment.

Study funding

No targeted funding reported.

Disclosure

The authors report no relevant disclosures. Go to Neurology.org/N for full disclosures.

Appendix Authors

Table
Table

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial, page 195

  • COVID-19 Resources: NPub.org/COVID19

  • Received April 4, 2020.
  • Accepted in final form April 23, 2020.
  • © 2020 American Academy of Neurology

References

  1. 1.↵
    1. Mao L,
    2. Wang M,
    3. Chen S, et al
    . Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China. JAMA Neurol. 2020;e201127.
  2. 2.↵
    1. Li YC,
    2. Bai WZ,
    3. Hashikawa T
    . The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552–555.
    OpenUrl
  3. 3.↵
    1. Zhou L,
    2. Zhang M,
    3. Wang J,
    4. Gao J
    . Sars-Cov-2: underestimated damage to nervous system. Trav Med Infect Dis Epub 2020 Mar 24.
  4. 4.↵
    1. Poyiadji N,
    2. Shahin G,
    3. Noujaim D,
    4. Stone M,
    5. Patel S,
    6. Griffith B
    . COVID-19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology; Epub 2020 Mar 31.
  5. 5.↵
    1. Wrapp D,
    2. Wang N,
    3. Corbett KS, et al
    . Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020;367:1260–1263.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Zhao H,
    2. Shen D,
    3. Zhou H,
    4. Liu J,
    5. Chen S
    . Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol 2020;19(5):383–384.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Gala F
    . Magnetic resonance imaging of optic nerve. Indian J Radiol Imaging 2015;25:421–428.
    OpenUrlCrossRefPubMed

Letters: Rapid online correspondence

  • Author response: COVID-19 presenting with ophthalmoparesis from cranial nerve palsy
    • Marc Dinkin, Director of Neuro-Ophthalmology, Weill Cornell Medical College, New York Presbyterian Hospital
    • Virginia Gao, Neurology resident, Weill Cornell Medical College, New York Presbyterian Hospital
    • Sarah Bobker, Neurology resident, Weill Cornell Medical College, New York Presbyterian Hospital
    • Marialaura Simonetto, Resident Physician, Weill Cornell Medical College, New York Presbyterian Hospital
    • Paul Wechsler, Neurology resident, Weill Cornell Medical College, New York Presbyterian Hospital
    • Jasmin Harpe, Neurology resident, Weill Cornell Medical College, New York Presbyterian Hospital
    • Christine Greer, Neuro-ophthalmology fellow, Weill Cornell Medical College, New York Presbyterian Hospital
    • Gregory Mints, Internal Medicine Physician, Weill Cornell Medical College, New York Presbyterian Hospital
    • Gayle Salama, Radiologist, Weill Cornell Medical College, New York Presbyterian Hospital
    • Apostolos J Tsiouris, Neuroradiologist, Weill Cornell Medical College, New York Presbyterian Hospital
    • Dana Leifer, Neurologist, Weill Cornell Medical College, New York Presbyterian Hospital
    • Joshua Kahan, MD, Weill Cornell Neurology (New York)
    Submitted June 09, 2020
  • Reader response: COVID-19 presenting with ophthalmoparesis from cranial nerve palsy
    • Calixto Machado, Neurologist, AAN Corresponding Fellow, Insttitute of Neurology and Neurosurgery (Havana, Cuba)
    Submitted June 02, 2020
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