Neurofilament light as a biomarker in traumatic brain injury
Citation Manager Formats
Make Comment
See Comments
This article has a correction. Please see:

Article Information
- Received August 29, 2019
- Accepted in final form January 7, 2020
- First Published July 8, 2020.
Article Versions
- Previous version (July 8, 2020 - 13:05).
- You are viewing the most recent version of this article.
Author Disclosures
- Pashtun Shahim, MD, PhD,
- Adam Politis, MS,
- Andre van der Merwe, BS,
- Brian Moore, PA-C, MPH,
- Yi-Yu Chou, MS,
- Dzung L. Pham, PhD,
- John A. Butman, MD, PhD,
- Ramon Diaz-Arrastia, MD, PhD,
- Jessica M. Gill, PhD,
- David L. Brody, MD, PhD,
- Henrik Zetterberg, MD, PhD,
- Kaj Blennow, MD, PhD and
- Leighton Chan, MD, MPH
- Pashtun Shahim, MD, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Adam Politis, MS,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Andre van der Merwe, BS,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Department of Defense (Center for Neuroscience and Regenerative Medicine) and the National Institutes of Health Intramural Research Program (Award Number: 63326), sponsor, 10 years
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Brian Moore, PA-C, MPH,
NONE
NONE
NONE
NONE
NONE
NONE
Henry M. Jackson Foundation for the Advancement of Military Medicine, physician assistant,3 years
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Yi-Yu Chou, MS,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Dzung L. Pham, PhD,
NONE
NONE
NONE
PLOS ONE, 5 years
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
CNRM/Uniformed Services University, ÂCNRM Image Processing CoreÂ, HU0001-09-2-0004, , Role: Core Director, 04/22/09- 06/30/20 CNRM/Uniformed Services University, ÂCharacterizing Microhemorrhages from Magnetic Resonance ImagingÂ, 307513- 5.01-60855, Role: Co-I, 04/01/15-03/31/20 NIH/NINDS, R56-NS055951, ÂIn Vivo Measurement of Brain Biomechanics, Role: Subaward PI, 09/01/18-08/31/20 NIH/NINDS, ÂMRI Measurement of the Mechanical Vulnerability of the Brain, U01-NS112120, Role: Subaward PI, 04/01/19- 09/30/24 CDMRP, ÂDetermining the Role of Tau and Amyloid in Chronic Symptoms and Deficits in Military Personnel Following TBIs through PET Imaging, W81XWH1810691, Role: Co- investigator, 09/15/18-09/14/21,
NONE
National MS Society, ÂImaging Biomarker Discovery With Advanced Brain Segmentation AlgorithmsÂ, RG-1507-05243, Role: PI, 04/01/16-03/31/20
NONE
NONE
NONE
NONE
NONE
NONE
- John A. Butman, MD, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
I am employed by the National Institutes of Health Stock/Stock Options, Medical Equipment & Materials: Medtronic > 10 years
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Ramon Diaz-Arrastia, MD, PhD,
NeuralAnalytics, Inc BrainBox Solutions, Inc FloTBI Pinteon Therapeutics MesoScale Discoveries
BrainBox Solutions, Inc. Pinteon Therapeutics
Quanterix, Inc
Journal of Neurotrauma Frontiers of Neuroscience
NONE
NONE
NONE
NONE
NONE
NONE
NONE
BrainBox Solutions, Inc
NIH/NINDS U01 NS086090 09/01/2013-08/30/2018 co-PI NIH/NINDS Project Title: ÂTransforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK TBI)Â DoD/USAMRAA Diaz-Arrastia (Co-PI) (Manley-PI) 09/01/2014- 08/31/2018 Project Title: ÂTBI Endpoints Development (TED)Â NIH/NINDS U01 NS099046 (Diaz-Arrastiaco-PI) 8/1/2018 Â 7/31/2023 2.4 $32,532,017 Project Title: Brain Oxygen Optimization in Severe TBIÂPhase 3 (BOOST-3) NIH/NINDS U24 NS107199 (R. Diaz-Arrastia, contact PI) 9/1/2018 Â 8/31/2023 Project title: Penn Center for Excellence in Neuroscience Clinical Trials (Penn NeuroNEXT) NIH/NINDS U01 NS114140 (R.Diaz-Arrastia, PI) 12/1/2019 Â 11/30/2024 Project Title: Clinical validation of serum neurofilament light as a biomarker of traumatic axonal injury US Dept. of Defense BA170613 (R. Diaz-Arrastia, PI) 9/1/2019 Â 8/30/2023 Project Title: Biomarkers of Brain Oxygen Optimization in Severe TBI Trial (Bio-BOOST) US Department of Defense EP180013 (R. Diaz-Arrastia, PI) 9/1/2019 Â 8/30/2023 Project Title: TRACK-TBI Epileptogenesis Project
NONE
NONE
Neural Analytics, Inc BrainBox Solutions, Inc Stock/Stock Options, Medical Equipment & Materials: Neural Analytics, Inc
NONE
NONE
NONE
NONE
NONE
- Jessica M. Gill, PhD,
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NIH intramural research, year 2012-current
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- David L. Brody, MD, PhD,
NONE
NONE
NONE
1) Acta Neuropathologica, editorial board, 2014-present 1) Journal of Neurotrauma, editorial board, 2013-present
Intracranial hemorrhage detection and treatment device for prolonged field care
Concussion Care Manual, Oxford University Press, 2018
NONE
NONE
NONE
NONE
NONE
NONE
1) NIH intramural research program, PI, 2017-present 2) USUHS, PI and center director, 2017-present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Henrik Zetterberg, MD, PhD,
HZ has served at advisory boards for Roche Diagnostics, Samumed, CogRx and Wave.
NONE
NONE
Journal of Alzheimer's Disease, Associate Editor Alzheimer's & Dementia, Associate Editor DADM, Associate Senior Editor Molecular and Cellular Neuroscience, Editor Scandinavian Journal of Clinical and Laboratory Investigation, Editor
NONE
NONE
NONE
NONE
NONE
HZ is co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg.
NONE
NONE
(1) The European Research Council (#681712), (2) Swedish State Support for Clinical Research (#ALFGBG-720931), and (3) the Knut and Alice Wallenberg Foundation.
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Kaj Blennow, MD, PhD and
Dr Blennow has served as a consultant or at advisory boards for Abcam, Azon Neuroscience, Biogen, Eli Lilly, MagQu, Novartis, and Roche Diagnostics
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg
NONE
Lundbeck, MagQu, UCB Pharma, Roche Diagnostics
LUA/ALF project, Västra Götalandsregionen, Sweden (project # ALFGBG- 11019)
Dr. Blennow holds the Torsten Söderberg professorship in Medicine.
The Torsten Söderberg Foundation at the Royal Swedish Academy of Sciences, the Alzheimer Foundation, Sweden, the Stiftelsen för Gamla Tjänarinnor, Stockholm, Sweden and Hjärnfonden, Sweden.
NONE
NONE
NONE
NONE
NONE
NONE
- Leighton Chan, MD, MPH
I serve on a DSMB for a NIH funded clinical trial. There is no compensation
NONE
NONE
Archives of Physical Medicine and Rehabilitation, Co- Editor in Chief. 2013- present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
I work for the the NIH Intramural Research Program 2007- present
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- From the NIH (P.S., A.P., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); Center for Neuroscience and Regenerative Medicine (P.S., A.v.d.M., B.M., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); The Henry M. Jackson Foundation for the Advancement of Military Medicine (P.S., A.v.d.M., B.M., J.M.G., D.L.B.), Bethesda, MD; Department of Psychiatry and Neurochemistry (P.S., H.Z., K.B.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Uniformed Services University of the Health Sciences (D.L.B.), Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; UK Dementia Research Institute at UCL (H.Z.); and Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London, UK.
- Correspondence
Dr. Shahim pashtun-poh.shahim{at}nih.gov
Article usage
Cited By...
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. David E. Vaillancourt and Dr. Shannon Y. Chiu
► Watch
Related Articles
Topics Discussed
Alert Me
Recommended articles
-
Article
Monitoring disease activity in multiple sclerosis using serum neurofilament light proteinLenka Novakova, Henrik Zetterberg, Peter Sundström et al.Neurology, October 27, 2017 -
Article
Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sportsPashtun Shahim, Henrik Zetterberg, Yelverton Tegner et al.Neurology, April 12, 2017 -
Article
Neurofilament light and tau as blood biomarkers for sports-related concussionPashtun Shahim, Yelverton Tegner, Niklas Marklund et al.Neurology, April 13, 2018 -
Article
Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBIPashtun Shahim, Adam Politis, Andre van der Merwe et al.Neurology, July 08, 2020