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August 18, 2020; 95 (7) Article

Late contributions of repetitive head impacts and TBI to depression symptoms and cognition

Michael L. Alosco, Yorghos Tripodis, Zachary H. Baucom, Jesse Mez, Thor D. Stein, Brett Martin, Olivia Haller, Shannon Conneely, Michael McClean, Rachel Nosheny, Scott Mackin, Ann C. McKee, Michael W. Weiner, Robert A. Stern
First published June 26, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010040
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Article Information

vol. 95 no. 7 e793-e804
DOI: 
https://doi.org/10.1212/WNL.0000000000010040
PubMed: 
32591472
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received October 11, 2019
  • Accepted in final form February 13, 2020
  • First Published June 26, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Michael L. Alosco, PhD*,
    2. Yorghos Tripodis, PhD*,
    3. Zachary H. Baucom, BA,
    4. Jesse Mez, MS, MD,
    5. Thor D. Stein, MD, PhD,
    6. Brett Martin, MS,
    7. Olivia Haller, BA,
    8. Shannon Conneely, BA,
    9. Michael McClean, ScD,
    10. Rachel Nosheny, PhD,
    11. Scott Mackin, PhD,
    12. Ann C. McKee, MD,
    13. Michael W. Weiner, MD† and
    14. Robert A. Stern, PhD†
  1. Michael L. Alosco, PhD*,
    2. Scientific Advisory Boards:

    1. Corino Therapeutics Inc

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. International Neuropsychological Society, Honoraria American Academy of Neurology Sports Concussion Conference, Honoraria

    Editorial Boards:

    1. Frontiers in Neurology, Section Neurotrauma, Editorial Board, Review Editor, 2020-pres. NeurologyLive, Editorial Board Member, 2019-pres

    Patents:

    1. NONE

    Publishing Royalties:

    1. Oxford Handbook of Adult Cognitive Disorders, Oxford University Press, 2019

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Corino Therapeutics Inc

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institutes of Health, K23NS102399, PI, 2018-2023 NIH, U54 NS115266 (McKee PI), Project PI, 09/01/2019-08/31/2024 NIH, R01AG062348 (McKee PI), Co-I, 09/30/2018-05/31/2023 NIH, FF1AG0579902, Co-I, 2017-2022 NIH, U01NS093334, Co-I, 2015-2022 DoD, AZ170038, Co-I, 2018-2021 NIH, P30AG13846, Clinical Core Co-Director, 2018-2020 NIH, R44A063635, Co-I, 2019-2021 NCT03591757, Co-I, 2018-2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association Research Grant, Site PI, 2017-2021

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Yorghos Tripodis, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIA, P30-AG13846, Biostatistician, 2011-2016 2) NIH, R01 ND078337, Biostatistician, 2011, 2015

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Zachary H. Baucom, BA,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. This work was supported by the National Institute of General Medical Sciences (NIGMS) Interdisciplinary Training Grant for Biostatisticians (T32 GM74905) from September 2017 to July 2020.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Jesse Mez, MS, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Concussion Legacy Foundation: Funding for travel American Academy of Neurology: Funding for travel and speaker honoraria International Neuropsychological Society: Funding for travel

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. World Wrestling Entertainment National Football League the National Operating Committee on Standards for Athletic Equipment (NOCSAE)

    Research Support, Government Entities:

    1. National Institute of Neurological Disorders and Stroke (U01NS086659, U01NS093334, R01NS078337, R56NS078337, K23NS102399) National Institute of Aging (P30AG13846; supplement 0572063345, R01AG057902, R01AG061028, K23AG046377, R01AG1649, R21HD089088, F32NS096803) Department of Veterans Affairs (I01 CX001135, CSP 501, B6796-C) Department of Defense (W81XWH-13-2-0095, W81XWH-13-2-0064, W81XWH1810580, PRARP-13267017)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer’s Association (NIRG-15-362697, NIRG-305779) Nick and Lynn Buoniconti Foundation Concussion Legacy Foundation Andlinger Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Thor D. Stein, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIH/NIA, RF1AG054156, PI, 9/15/2016-9/14/2021 2) NIH/NIA, RF1AG057768, PI, 02/01/2019-1/31/2024 3) VHA/ VA Merit Award I01CX001038, PI, 10/1/18 to 9/30/22

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Brett Martin, MS,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Olivia Haller, BA,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Shannon Conneely, BA,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Michael McClean, ScD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 5U01NS093334, NIH/NINDS, PI: Stern 09/01/2015-08/31/2020 Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course and Risk Factors Role: Coinvestigator 5P42ES007381, NIH/NIEHS, PI: Sherr 04/01/1997 – 03/31/2020 Superfund Research Program at Boston University Role: Co-PI of Training Core 1R01ES027584, NIH/NIEHS, PI: Scammell 12/1/16-11/30/21 Longitudinal study of risk factors and progression of Mesoamerican Nephropathy among agricultural workers in El Salvador, Central America Role: Coinvestigator 5R01ES024749, NIH/NIEHS, PI: Wise 09/30/2015 – 06/30/2020 Endocrine disrupting chemicals and risk of uterine fibroids: a prospective study Role: Co-Investigator 1R01ES029951, NIH/NIEHS, CoPIs: Wise and Hatch 01/01/19 - 10/31/23 A preconception cohort study of environmental chemicals, fertility, and miscarriage Role: Co-Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Rachel Nosheny, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and 1Florida ADRC, travel

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH, K01 AG055692-01, PI, 2017-2022 CA Dept Public Health, 16-10054, Researcher, 2016-2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Larry L. Hillblom Foundation, 2015-A-011-NET, CO-I, 2016-2019 Alzheimer’s Association, BHR-16-459161, CO-I, 2016-2020

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Scott Mackin, PhD,
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Johnson and Johnson research support

    Research Support, Government Entities:

    1. NIMH Ro1 098062nimh Ro1 101472NIMH RO1 117114

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Ann C. McKee, MD,
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. The Seminar, La Cantera Resort, San Antonio, speaking honoraria Princeton University, Princeton, New Jersey, speaking honoraria University of British Columbia, Vancouver, BC, travel 13th Göttingen German Neuroscience Society, Gottingen Germany, travel British Neuroscience Association, Dublin, Ireland, travel European Congress of Sport Science, Prague, Czech Republic, travel

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. Title: Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD, ADRD and CTE Neuropathology and Resulting Clinical Syndromes Role in Project: Ann McKee, PI Type of Grant: U54 Funding Agency: NINDS/NIA, U54-NS-115266-01 Years Funded: 09/01/2019 – 08/31/2024 Total Direct Costs: $1,250,000/yr; $10,000,000/5 yrs 2.Title: The Contribution of Age-Related Tauopathies to Alzheimer's Disease Role in Project: Ann McKee, PI (contact), John Fonda Crary, Dennis Dickson PI Funding Agency: NIA, R01AG062348 Years Funded: 09/30/2018 – 05/31/2023 Total Direct Costs: $500,000/yr 3.Title: Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation Role in Project: Ann McKee, PI Type of Grant: RO1 Funding Agency: NIA, 1RF1AG057902-01 Years Funded: 9/15/2017-9/14/2022 Total Direct Costs: $500,000/ yr 4. Title: Neuropathology Core, Boston University Alzheimer’s Disease Core Center Role in Project: Director of Neuropathology Core; Co-Investigator Type of Grant: P30 Center Grant (N. Kowall, PI) P30-AG13846 Funding Agency: National Institute on Aging Years Funded: 7/1/1996-6/30/2019 Total Direct Costs: $965,065 The major goal of this project is to build a broad-based research program in Alzheimer’s disease to better understand the phenomenology and pathophysiology of Alzheimer’s disease and related dementias, and to facilitate treatment and prevention. 5. Title: CTBI: CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery Role in Project: Ann McKee, PI Type of Grant: VA Merit Award Funding Agency: Veterans Administration, U.S. Government Years Funded: 4/01/2019-03/31/2023 Total Direct Costs: $1,000,000 Program: Neuropathological alterations after Blast TBI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Nick and Lynn Buoniconti Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  13. Michael W. Weiner, MD† and
    14. Scientific Advisory Boards:

    1. He has served on Advisory Boards for Eli Lilly, Cerecin/Accera, Roche, Alzheon, Inc., Merck Sharp & Dohme Corp., Nestle/Nestec, PCORI/PPRN, Dolby Family Ventures, National Institute on Aging (NIA), Brain Health Registry and ADNI.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. The following entities have provided funding for academic travel; Kenes, Intl., Merck, ADCS, ATRI, Eli Lilly, The Alzheimer’s Association, Merck, Tokyo University, Kyoto University, AAN, AC Immune, CHU Toulouse, St. George Hospital University, Indiana U., U. Melbourne, Australian Catholic University, Japanese Government Alliance, National Center for Geriatrics and Gerontology (Japan), US Against Alzheimer’s, NYU, USC, and SNMMI.

    Editorial Boards:

    1. He serves on the Editorial Boards for Alzheimer’s & Dementia, TMRI and MRI.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. University of California, San Francisco; San Francisco VA Medical Center (WOC employment)

    Consultancies:

    1. He has provided consulting and/or acted as a speaker/lecturer to Cerecin/Accera, Inc., Alzheimer’s Drug Discovery Foundation (ADDF), Merck, BioClinica, Eli Lilly, Indiana University, Howard University, Nestle/Nestec, Roche, Genentech, NIH, Lynch Group GLC, Health & Wellness Partners, Bionest Partners, American Academy of Neurology (AAN), NYU, Japanese Government Alliance, National Center for Geriatrics and Gerontology (Japan), US Against Alzheimer’s, Society for Nuclear Medicine and Molecular Imaging (SNMMI), The Buck Institute for Research on Aging, FUJIFILM-Toyama Chemical (Japan), and T3D Therapeutics.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Dr. Weiner receives support for his work from the following funding sources: NIH: 5U19AG024904-14; 1R01AG053798-01A1; R01 MH098062; U24 AG057437-01; 1U2CA060426-01; 1R01AG058676-01A1; and 1RF1AG059009-01, DOD: W81XWH-15-2-0070; 0W81XWH-12-2-0012; W81XWH-14-1-0462; W81XWH-13-1-0259, PCORI: PPRN-1501-26817, California Dept. of Public Health: 16-10054, U. Michigan: 18-PAF01312, Siemens: 444951-54249, Biogen: 174552, Hillblom Foundation: 2015-A-011-NET, Alzheimer’s Association: BHR-16-459161; The State of California: 18-109929. He also receives support from Johnson & Johnson, Kevin and Connie Shanahan, GE, VUmc, Australian Catholic University (HBI-BHR), The Stroke Foundation, and the Veterans Administration.

    Research Support, Government Entities:

    1. NIH, DOD, VA Stock/Stock Options, Medical Equipment & Materials: He holds stock options with Alzheon, Inc., Alzeca, and Anven.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  14. Robert A. Stern, PhD†
    15. Scientific Advisory Boards:

    1. (1) Biogen, Member of Alzheimer's Medical Advisory Board;(2) Eli Lilly, Member, Executive Committee for AZD3293 Alzheimer’s Disease Studies;(3) NCAA Student-Athlete Concussion Injury Litigation, Court-Appointed Member, Medical Scientific Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Neuropsychiatry and Clinical Neurosciences, Associate Editor, 1998-2018;(2) Frontiers in Neurotrauma, Review Editor, 2010-Present;(3) Journal of Alzheimer's Disease, Associate Editor, 2016-Present

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Visual Analog Mood Scales, Psychological Assessment Resources, Inc., 1997-Present, (2) Boston Qualitative Scoring System for the Rey-Osterreith Complex Figure, Psychological Assessment Resources, Inc., 1999-Present, (3) Neuropsychological Assessment Resources, Inc., 2003- Present

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1)Eisai Inc., (2)Eli Lilly, (3)Avid Radiopharmaceuticals, (4) Novartis Pharmaceuticals, (5) Janssen Research & Development

    Research Support, Government Entities:

    1. (1) NIH, U01NS093334, mPI (Contact), 2015-2022 (2) NIH, R01NS078337, PI, 2011-2014, (3) NIH, P30- AG13846, Clinical Core Director, 2004-2019, (4) NIH, U01NS086659, Co-I, 2013-2018, (5) NIH, R01AG062624, Subaward PI, 2019-2022, (6) Department of Defense, W81XWH- 13-2-0064, Co-PI, 2013-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Concussion Legacy Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. King-Devick Technologies, Inc.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (M.L.A., J.M., O.H., S.C., A.C.M., R.A.S.), Pathology & Laboratory Medicine (T.D.S., A.C.M.), Boston University Alzheimer's Disease Center and CTE Center (Y.T., B.M.), and Departments of Neurosurgery (R.A.S.) and Anatomy and Neurobiology (R.A.S.), Boston University School of Medicine; Department of Biostatistics (Y.T., Z.H.B.), Biostatistics and Epidemiology Data Analytics Center (B.M.), and Department of Environmental Health (M.M.), Boston University School of Public Health, MA; VA Boston Healthcare System (T.D.S., A.C.M.); Department of Veterans Affairs Medical Center (T.D.S., A.C.M.), Bedford, MA; Departments of Psychiatry (R.N., S.M., M.W.W.), Radiology (M.W.W.), Biomedical Imaging (M.W.W.), Medicine (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco; and Department of Veterans Affairs Medical Center (R.N., S.M., M.W.W.), Center for Imaging and Neurodegenerative Diseases, San Francisco, CA.
  1. Correspondence
    Dr. Alosco malosco{at}bu.edu
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