Late contributions of repetitive head impacts and TBI to depression symptoms and cognition
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Article Information
- Received October 11, 2019
- Accepted in final form February 13, 2020
- First Published June 26, 2020.
Article Versions
- Previous version (June 26, 2020 - 12:55).
- You are viewing the most recent version of this article.
Author Disclosures
- Michael L. Alosco, PhD*,
- Yorghos Tripodis, PhD*,
- Zachary H. Baucom, BA,
- Jesse Mez, MS, MD,
- Thor D. Stein, MD, PhD,
- Brett Martin, MS,
- Olivia Haller, BA,
- Shannon Conneely, BA,
- Michael McClean, ScD,
- Rachel Nosheny, PhD,
- Scott Mackin, PhD,
- Ann C. McKee, MD,
- Michael W. Weiner, MD† and
- Robert A. Stern, PhD†
- Michael L. Alosco, PhD*,
Corino Therapeutics Inc
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International Neuropsychological Society, Honoraria American Academy of Neurology Sports Concussion Conference, Honoraria
Frontiers in Neurology, Section Neurotrauma, Editorial Board, Review Editor, 2020-pres. NeurologyLive, Editorial Board Member, 2019-pres
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Oxford Handbook of Adult Cognitive Disorders, Oxford University Press, 2019
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Corino Therapeutics Inc
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National Institutes of Health, K23NS102399, PI, 2018-2023 NIH, U54 NS115266 (McKee PI), Project PI, 09/01/2019-08/31/2024 NIH, R01AG062348 (McKee PI), Co-I, 09/30/2018-05/31/2023 NIH, FF1AG0579902, Co-I, 2017-2022 NIH, U01NS093334, Co-I, 2015-2022 DoD, AZ170038, Co-I, 2018-2021 NIH, P30AG13846, Clinical Core Co-Director, 2018-2020 NIH, R44A063635, Co-I, 2019-2021 NCT03591757, Co-I, 2018-2019
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Alzheimer's Association Research Grant, Site PI, 2017-2021
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- Yorghos Tripodis, PhD*,
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1) NIA, P30-AG13846, Biostatistician, 2011-2016 2) NIH, R01 ND078337, Biostatistician, 2011, 2015
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- Zachary H. Baucom, BA,
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This work was supported by the National Institute of General Medical Sciences (NIGMS) Interdisciplinary Training Grant for Biostatisticians (T32 GM74905) from September 2017 to July 2020.
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- Jesse Mez, MS, MD,
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Concussion Legacy Foundation: Funding for travel American Academy of Neurology: Funding for travel and speaker honoraria International Neuropsychological Society: Funding for travel
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World Wrestling Entertainment National Football League the National Operating Committee on Standards for Athletic Equipment (NOCSAE)
National Institute of Neurological Disorders and Stroke (U01NS086659, U01NS093334, R01NS078337, R56NS078337, K23NS102399) National Institute of Aging (P30AG13846; supplement 0572063345, R01AG057902, R01AG061028, K23AG046377, R01AG1649, R21HD089088, F32NS096803) Department of Veterans Affairs (I01 CX001135, CSP 501, B6796-C) Department of Defense (W81XWH-13-2-0095, W81XWH-13-2-0064, W81XWH1810580, PRARP-13267017)
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AlzheimerÂs Association (NIRG-15-362697, NIRG-305779) Nick and Lynn Buoniconti Foundation Concussion Legacy Foundation Andlinger Foundation
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- Thor D. Stein, MD, PhD,
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1) NIH/NIA, RF1AG054156, PI, 9/15/2016-9/14/2021 2) NIH/NIA, RF1AG057768, PI, 02/01/2019-1/31/2024 3) VHA/ VA Merit Award I01CX001038, PI, 10/1/18 to 9/30/22
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- Brett Martin, MS,
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- Olivia Haller, BA,
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- Shannon Conneely, BA,
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- Michael McClean, ScD,
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5U01NS093334, NIH/NINDS, PI: Stern 09/01/2015-08/31/2020 Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course and Risk Factors Role: Coinvestigator 5P42ES007381, NIH/NIEHS, PI: Sherr 04/01/1997 Â 03/31/2020 Superfund Research Program at Boston University Role: Co-PI of Training Core 1R01ES027584, NIH/NIEHS, PI: Scammell 12/1/16-11/30/21 Longitudinal study of risk factors and progression of Mesoamerican Nephropathy among agricultural workers in El Salvador, Central America Role: Coinvestigator 5R01ES024749, NIH/NIEHS, PI: Wise 09/30/2015 Â 06/30/2020 Endocrine disrupting chemicals and risk of uterine fibroids: a prospective study Role: Co-Investigator 1R01ES029951, NIH/NIEHS, CoPIs: Wise and Hatch 01/01/19 - 10/31/23 A preconception cohort study of environmental chemicals, fertility, and miscarriage Role: Co-Investigator
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- Rachel Nosheny, PhD,
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The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and 1Florida ADRC, travel
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NIH, K01 AG055692-01, PI, 2017-2022 CA Dept Public Health, 16-10054, Researcher, 2016-2019
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Larry L. Hillblom Foundation, 2015-A-011-NET, CO-I, 2016-2019 AlzheimerÂs Association, BHR-16-459161, CO-I, 2016-2020
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- Scott Mackin, PhD,
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Johnson and Johnson research support
NIMH Ro1 098062nimh Ro1 101472NIMH RO1 117114
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- Ann C. McKee, MD,
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The Seminar, La Cantera Resort, San Antonio, speaking honoraria Princeton University, Princeton, New Jersey, speaking honoraria University of British Columbia, Vancouver, BC, travel 13th Göttingen German Neuroscience Society, Gottingen Germany, travel British Neuroscience Association, Dublin, Ireland, travel European Congress of Sport Science, Prague, Czech Republic, travel
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1. Title: Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD, ADRD and CTE Neuropathology and Resulting Clinical Syndromes Role in Project: Ann McKee, PI Type of Grant: U54 Funding Agency: NINDS/NIA, U54-NS-115266-01 Years Funded: 09/01/2019 Â 08/31/2024 Total Direct Costs: $1,250,000/yr; $10,000,000/5 yrs 2.Title: The Contribution of Age-Related Tauopathies to Alzheimer's Disease Role in Project: Ann McKee, PI (contact), John Fonda Crary, Dennis Dickson PI Funding Agency: NIA, R01AG062348 Years Funded: 09/30/2018 Â 05/31/2023 Total Direct Costs: $500,000/yr 3.Title: Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation Role in Project: Ann McKee, PI Type of Grant: RO1 Funding Agency: NIA, 1RF1AG057902-01 Years Funded: 9/15/2017-9/14/2022 Total Direct Costs: $500,000/ yr 4. Title: Neuropathology Core, Boston University AlzheimerÂs Disease Core Center Role in Project: Director of Neuropathology Core; Co-Investigator Type of Grant: P30 Center Grant (N. Kowall, PI) P30-AG13846 Funding Agency: National Institute on Aging Years Funded: 7/1/1996-6/30/2019 Total Direct Costs: $965,065 The major goal of this project is to build a broad-based research program in AlzheimerÂs disease to better understand the phenomenology and pathophysiology of AlzheimerÂs disease and related dementias, and to facilitate treatment and prevention. 5. Title: CTBI: CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery Role in Project: Ann McKee, PI Type of Grant: VA Merit Award Funding Agency: Veterans Administration, U.S. Government Years Funded: 4/01/2019-03/31/2023 Total Direct Costs: $1,000,000 Program: Neuropathological alterations after Blast TBI
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Nick and Lynn Buoniconti Foundation
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- Michael W. Weiner, MD† and
He has served on Advisory Boards for Eli Lilly, Cerecin/Accera, Roche, Alzheon, Inc., Merck Sharp & Dohme Corp., Nestle/Nestec, PCORI/PPRN, Dolby Family Ventures, National Institute on Aging (NIA), Brain Health Registry and ADNI.
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The following entities have provided funding for academic travel; Kenes, Intl., Merck, ADCS, ATRI, Eli Lilly, The AlzheimerÂs Association, Merck, Tokyo University, Kyoto University, AAN, AC Immune, CHU Toulouse, St. George Hospital University, Indiana U., U. Melbourne, Australian Catholic University, Japanese Government Alliance, National Center for Geriatrics and Gerontology (Japan), US Against AlzheimerÂs, NYU, USC, and SNMMI.
He serves on the Editorial Boards for AlzheimerÂs & Dementia, TMRI and MRI.
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University of California, San Francisco; San Francisco VA Medical Center (WOC employment)
He has provided consulting and/or acted as a speaker/lecturer to Cerecin/Accera, Inc., AlzheimerÂs Drug Discovery Foundation (ADDF), Merck, BioClinica, Eli Lilly, Indiana University, Howard University, Nestle/Nestec, Roche, Genentech, NIH, Lynch Group GLC, Health & Wellness Partners, Bionest Partners, American Academy of Neurology (AAN), NYU, Japanese Government Alliance, National Center for Geriatrics and Gerontology (Japan), US Against AlzheimerÂs, Society for Nuclear Medicine and Molecular Imaging (SNMMI), The Buck Institute for Research on Aging, FUJIFILM-Toyama Chemical (Japan), and T3D Therapeutics.
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Dr. Weiner receives support for his work from the following funding sources: NIH: 5U19AG024904-14; 1R01AG053798-01A1; R01 MH098062; U24 AG057437-01; 1U2CA060426-01; 1R01AG058676-01A1; and 1RF1AG059009-01, DOD: W81XWH-15-2-0070; 0W81XWH-12-2-0012; W81XWH-14-1-0462; W81XWH-13-1-0259, PCORI: PPRN-1501-26817, California Dept. of Public Health: 16-10054, U. Michigan: 18-PAF01312, Siemens: 444951-54249, Biogen: 174552, Hillblom Foundation: 2015-A-011-NET, AlzheimerÂs Association: BHR-16-459161; The State of California: 18-109929. He also receives support from Johnson & Johnson, Kevin and Connie Shanahan, GE, VUmc, Australian Catholic University (HBI-BHR), The Stroke Foundation, and the Veterans Administration.
NIH, DOD, VA Stock/Stock Options, Medical Equipment & Materials: He holds stock options with Alzheon, Inc., Alzeca, and Anven.
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- Robert A. Stern, PhD†
(1) Biogen, Member of Alzheimer's Medical Advisory Board;(2) Eli Lilly, Member, Executive Committee for AZD3293 AlzheimerÂs Disease Studies;(3) NCAA Student-Athlete Concussion Injury Litigation, Court-Appointed Member, Medical Scientific Committee
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(1) Journal of Neuropsychiatry and Clinical Neurosciences, Associate Editor, 1998-2018;(2) Frontiers in Neurotrauma, Review Editor, 2010-Present;(3) Journal of Alzheimer's Disease, Associate Editor, 2016-Present
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(1) Visual Analog Mood Scales, Psychological Assessment Resources, Inc., 1997-Present, (2) Boston Qualitative Scoring System for the Rey-Osterreith Complex Figure, Psychological Assessment Resources, Inc., 1999-Present, (3) Neuropsychological Assessment Resources, Inc., 2003- Present
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(1)Eisai Inc., (2)Eli Lilly, (3)Avid Radiopharmaceuticals, (4) Novartis Pharmaceuticals, (5) Janssen Research & Development
(1) NIH, U01NS093334, mPI (Contact), 2015-2022 (2) NIH, R01NS078337, PI, 2011-2014, (3) NIH, P30- AG13846, Clinical Core Director, 2004-2019, (4) NIH, U01NS086659, Co-I, 2013-2018, (5) NIH, R01AG062624, Subaward PI, 2019-2022, (6) Department of Defense, W81XWH- 13-2-0064, Co-PI, 2013-2016
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(1) Concussion Legacy Foundation
King-Devick Technologies, Inc.
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- From the Departments of Neurology (M.L.A., J.M., O.H., S.C., A.C.M., R.A.S.), Pathology & Laboratory Medicine (T.D.S., A.C.M.), Boston University Alzheimer's Disease Center and CTE Center (Y.T., B.M.), and Departments of Neurosurgery (R.A.S.) and Anatomy and Neurobiology (R.A.S.), Boston University School of Medicine; Department of Biostatistics (Y.T., Z.H.B.), Biostatistics and Epidemiology Data Analytics Center (B.M.), and Department of Environmental Health (M.M.), Boston University School of Public Health, MA; VA Boston Healthcare System (T.D.S., A.C.M.); Department of Veterans Affairs Medical Center (T.D.S., A.C.M.), Bedford, MA; Departments of Psychiatry (R.N., S.M., M.W.W.), Radiology (M.W.W.), Biomedical Imaging (M.W.W.), Medicine (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco; and Department of Veterans Affairs Medical Center (R.N., S.M., M.W.W.), Center for Imaging and Neurodegenerative Diseases, San Francisco, CA.
- Correspondence
Dr. Alosco malosco{at}bu.edu
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- Reader response: The Late Contributions of Repetitive Head Impacts and TBI to Depression Symptoms and Cognition
- Barbara B. Bendlin, PhD, Associate Professor, University of Wisconsin-Madison, School of Medicine and Public Health
Submitted July 06, 2020
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