Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans
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Article Information
- Received September 30, 2019
- Accepted in final form February 27, 2020
- First Published June 22, 2020.
Article Versions
- Previous version (June 22, 2020 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Carrie B. Peltz, PhD,
- Kimbra Kenney, MD,
- Jessica Gill, PhD,
- Ramon Diaz-Arrastia, MD, PhD,
- Raquel C. Gardner, MD and
- Kristine Yaffe, MD
- Carrie B. Peltz, PhD,
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1. DOD W81XWH-14-2-0137, Study Coordinator, 2014-current 2. DOD, W81XWh-14-1-0467, Study Coordinator, 2014-current
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- Kimbra Kenney, MD,
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- Jessica Gill, PhD,
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NIH intramural research, year 2012-current
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- Ramon Diaz-Arrastia, MD, PhD,
NeuralAnalytics, Inc BrainBox Solutions, Inc FloTBI Pinteon Therapeutics MesoScale Discoveries
BrainBox Solutions, Inc. Pinteon Therapeutics
Quanterix, Inc
Journal of Neurotrauma Frontiers of Neuroscience
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BrainBox Solutions, Inc
NIH/NINDS U01 NS086090 09/01/2013-08/30/2018 co-PI NIH/NINDS Project Title: ÂTransforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK TBI)Â DoD/USAMRAA Diaz-Arrastia (Co-PI) (Manley-PI) 09/01/2014- 08/31/2018 Project Title: ÂTBI Endpoints Development (TED)Â NIH/NINDS U01 NS099046 (Diaz-Arrastiaco-PI) 8/1/2018 Â 7/31/2023 2.4 $32,532,017 Project Title: Brain Oxygen Optimization in Severe TBIÂPhase 3 (BOOST-3) NIH/NINDS U24 NS107199 (R. Diaz-Arrastia, contact PI) 9/1/2018 Â 8/31/2023 Project title: Penn Center for Excellence in Neuroscience Clinical Trials (Penn NeuroNEXT) NIH/NINDS U01 NS114140 (R.Diaz-Arrastia, PI) 12/1/2019 Â 11/30/2024 Project Title: Clinical validation of serum neurofilament light as a biomarker of traumatic axonal injury US Dept. of Defense BA170613 (R. Diaz-Arrastia, PI) 9/1/2019 Â 8/30/2023 Project Title: Biomarkers of Brain Oxygen Optimization in Severe TBI Trial (Bio-BOOST) US Department of Defense EP180013 (R. Diaz-Arrastia, PI) 9/1/2019 Â 8/30/2023 Project Title: TRACK-TBI Epileptogenesis Project
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Neural Analytics, Inc BrainBox Solutions, Inc Stock/Stock Options, Medical Equipment & Materials: Neural Analytics, Inc
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- Raquel C. Gardner, MD and
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(1) NIH, reimbursement for travel to a conference at NIH in 2019
2017-present: PLOS Medicine, Academic Editor
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NINDS, Beeson K23 NS095755, PI, 2015-2020 NINDS, R01 NS110944, PI, 2019-2024 Department of Defense, W81XWH-18-1-0514, PI, 2018-2021 Department of Defense, W81XWH-18-PRARP-RPA, multi-PI, 2019- 2022
(1) UCSF Pepper Center Research Career Development Core (2) UCSF Research Allocation Program (3) UCSF Weill Institute for Neuroscience
(1) American Federation for Aging Research (2) Global Brain Health Institute
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- Kristine Yaffe, MD
1)DSMB for Eli Lilly 2)DSMB for NIH sponsored study 3)Beeson Scientific Advisory Board 4)Global Council on Brain Health Governance Committee 5)Board member of Alector
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-Associate Editor, 2011-, International Review of Psychiatry -Editorial Board Member 2014-, Journal of Prevention of AlzheimerÂs Disease - Editorial Board Member 2017-, AlzheimerÂs & Dementia: Translational Research & Clinical Interventions - Editorial Board Member 2018-, Translational Neurodegeneration
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1. K24 AG031155 (PI) NIA Predictors of cognitive aging across the lifecourse 06/13-11/20 2. Director Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center Psychiatric Fellowship 10/09-09/23 3. PI of Dementia Research at SF VA Medical Center Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center 10/09-09/23 4. (Co-Investigator, PI: Cifu) Department of Defense/VA Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 07/13-09/19 5. W81XWH-14-2-0137 (PI: Yaffe) Department of Defense Blood biomarker profile of TBI-associated cognitive impairment among old & young veterans 10/14-09/19 6. W81XWH-14-2-0176 (Co-Investigator, PI: Manley) Department of Defense Traumatic Brain Injury Endpoints Development (TED) Award 10/14-09/19 7. R01 HL122658 (Multiple PI: Yaffe and Sidney) NHLBI Determinants of Midlife & Longitudinal Change in Cognitive Function 12/14-11/19 8. W81XWH-12-PHTBI-CENC (PI: Yaffe) Department of Defense/VA Epidemiology Project. Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 02/15-09/19 9. R01 AG048234 (Co-investigator, PI: Kramer) NIA Effects of Chronic Inflammation on Brain Structure and Function 04/15-01/20 10. R01 AG032289 (Co-investigator, PI: Kramer) NIA Biological predictors of brain aging trajectories 09/15-05/20 11. R01 AG052964 (Co-investigator, PI: Cummings) NIA Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins 06/16-05/21 12. RF1 G050745 (Co-investigator, PI: Spira) NIA The ARIC study of midlife sleep and late-life brain amyloid 06/16-05/21 13. UL1 TR991872 (Director of Pilot Grants Program, PI: Grandis) National Center for Advancing Translational Sciences Clinical and Translational Science Institute 07/16-06/21 14. W81XWH-16-1-0507 (PI: Yaffe) Department of Defense Risk and Resiliency for Dementia: Comparison of Male and Female Veterans 08/16-08/19 15. RF1 AG054443 (Multiple PI: Yaffe and Zeki-Al Hazzouri) NIA Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment 05/17-04/21 16. R01 AG054073 (Multiple PI: Yaffe/OÂBryant/Toga) NIA Health Disparities in AlzheimerÂs Disease and Mild Cognitive Impairment among Mexican Americans 09/17-05/22 17. R01 AG057508 (Multiple PI: Yaffe/Larson) NIA Systematic Multi-Domain AlzheimerÂs Risk Reduction Trial 09/17-05/21 18. R13 AG058415 (Multiple PI: Yaffe/Gill) American Federation for Aging Research Paul B Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting 09/17-05/22 19. R01 AG058537 (Multiple PI: Yaffe/OÂBryant) NIA An AlzheimerÂs Blood Test for Primary Care 6/18-5/21 20. P30 AG044281 (Co-Investigator, PI: Covinsky) NIA UCSF Older American Independence Center 07/18-06/23 21. W81XWH-18-1-0692 (Multiple PI: Yaffe/Plassman) Department of Army Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia 9/18-09/21 22. P30 AG062422 (REC Core PI and Data Core Co- Investigator; PI: Miller) NIH New Approaches to Dementia Heterogeneity (AlzheimerÂs Disease Research Centers) 04/19-03/24
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1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists 2) AlzheimerÂs Drug Discovery Foundation Connection Between Depressive Symptoms and Dementia:When Best to Intervene? 3)2018-A-006-NET (Co-Investigator, PI: Kramer) Larry L. Hillblom Foundation Hillblom Network for the Prevention of Age-Associated Cognitive Decline
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- From San Francisco Veterans Affairs Health Care System (C.B.P., R.C.G., K.Y.), CA; Northern California Institute for Research and Education (C.B.P.), San Francisco; Uniformed Services University of the Health Sciences (K.K.), Rockville; NIH (J.G.), Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; and Departments of Neurology (R.C.G., K.Y.), Psychiatry (K.Y.), and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco.
- Correspondence
Dr. Peltz carrie.peltz{at}ncire.org
Article usage
Cited By...
Letters: Rapid online correspondence
- Author response: Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans
- Carrie B. Peltz, Research Associate, San Francisco Veterans Affairs Health Care System
- Kristine Yaffe, Scola Endowed Chair and Vice Chair, Professor of Psychiatry, Neurology and Epidemiology, University of California, San Francisco
Submitted July 28, 2020 - Reader response: Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans
- Thomas Wisniewski, MD, Director of the NYU Alzheimer’s Disease Research Center, New York University School of Medicine
- Silvia Fossati, MD, Associate Director Alzheimer’s Center at Temple, Temple University (Philadelphia)
Submitted July 23, 2020
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