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September 01, 2020; 95 (9) Article

Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans

Carrie B. Peltz, Kimbra Kenney, Jessica Gill, Ramon Diaz-Arrastia, Raquel C. Gardner, Kristine Yaffe
First published June 22, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010087
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Article Information

vol. 95 no. 9 e1126-e1133
DOI: 
https://doi.org/10.1212/WNL.0000000000010087
PubMed: 
32571850
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 30, 2019
  • Accepted in final form February 27, 2020
  • First Published June 22, 2020.

Article Versions

Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Carrie B. Peltz, PhD,
    2. Kimbra Kenney, MD,
    3. Jessica Gill, PhD,
    4. Ramon Diaz-Arrastia, MD, PhD,
    5. Raquel C. Gardner, MD and
    6. Kristine Yaffe, MD
  1. Carrie B. Peltz, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. DOD W81XWH-14-2-0137, Study Coordinator, 2014-current 2. DOD, W81XWh-14-1-0467, Study Coordinator, 2014-current

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Kimbra Kenney, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Jessica Gill, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH intramural research, year 2012-current

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Ramon Diaz-Arrastia, MD, PhD,
    5. Scientific Advisory Boards:

    1. NeuralAnalytics, Inc BrainBox Solutions, Inc FloTBI Pinteon Therapeutics MesoScale Discoveries

    Gifts:

    1. BrainBox Solutions, Inc. Pinteon Therapeutics

    Funding for travel or speaker honoraria:

    1. Quanterix, Inc

    Editorial Boards:

    1. Journal of Neurotrauma Frontiers of Neuroscience

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. BrainBox Solutions, Inc

    Research Support, Government Entities:

    1. NIH/NINDS U01 NS086090 09/01/2013-08/30/2018 co-PI NIH/NINDS Project Title: “Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK TBI)” DoD/USAMRAA Diaz-Arrastia (Co-PI) (Manley-PI) 09/01/2014- 08/31/2018 Project Title: “TBI Endpoints Development (TED)” NIH/NINDS U01 NS099046 (Diaz-Arrastiaco-PI) 8/1/2018 – 7/31/2023 2.4 $32,532,017 Project Title: Brain Oxygen Optimization in Severe TBI—Phase 3 (BOOST-3) NIH/NINDS U24 NS107199 (R. Diaz-Arrastia, contact PI) 9/1/2018 – 8/31/2023 Project title: Penn Center for Excellence in Neuroscience Clinical Trials (Penn NeuroNEXT) NIH/NINDS U01 NS114140 (R.Diaz-Arrastia, PI) 12/1/2019 – 11/30/2024 Project Title: Clinical validation of serum neurofilament light as a biomarker of traumatic axonal injury US Dept. of Defense BA170613 (R. Diaz-Arrastia, PI) 9/1/2019 – 8/30/2023 Project Title: Biomarkers of Brain Oxygen Optimization in Severe TBI Trial (Bio-BOOST) US Department of Defense EP180013 (R. Diaz-Arrastia, PI) 9/1/2019 – 8/30/2023 Project Title: TRACK-TBI Epileptogenesis Project

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Neural Analytics, Inc BrainBox Solutions, Inc Stock/Stock Options, Medical Equipment & Materials: Neural Analytics, Inc

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Raquel C. Gardner, MD and
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) NIH, reimbursement for travel to a conference at NIH in 2019

    Editorial Boards:

    1. 2017-present: PLOS Medicine, Academic Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS, Beeson K23 NS095755, PI, 2015-2020 NINDS, R01 NS110944, PI, 2019-2024 Department of Defense, W81XWH-18-1-0514, PI, 2018-2021 Department of Defense, W81XWH-18-PRARP-RPA, multi-PI, 2019- 2022

    Research Support, Academic Entities:

    1. (1) UCSF Pepper Center Research Career Development Core (2) UCSF Research Allocation Program (3) UCSF Weill Institute for Neuroscience

    Research Support, Foundations and Societies:

    1. (1) American Federation for Aging Research (2) Global Brain Health Institute

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Kristine Yaffe, MD
    7. Scientific Advisory Boards:

    1. 1)DSMB for Eli Lilly 2)DSMB for NIH sponsored study 3)Beeson Scientific Advisory Board 4)Global Council on Brain Health Governance Committee 5)Board member of Alector

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry -Editorial Board Member 2014-, Journal of Prevention of Alzheimer’s Disease - Editorial Board Member 2017-, Alzheimer’s & Dementia: Translational Research & Clinical Interventions - Editorial Board Member 2018-, Translational Neurodegeneration

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. K24 AG031155 (PI) NIA Predictors of cognitive aging across the lifecourse 06/13-11/20 2. Director Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center Psychiatric Fellowship 10/09-09/23 3. PI of Dementia Research at SF VA Medical Center Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center 10/09-09/23 4. (Co-Investigator, PI: Cifu) Department of Defense/VA Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 07/13-09/19 5. W81XWH-14-2-0137 (PI: Yaffe) Department of Defense Blood biomarker profile of TBI-associated cognitive impairment among old & young veterans 10/14-09/19 6. W81XWH-14-2-0176 (Co-Investigator, PI: Manley) Department of Defense Traumatic Brain Injury Endpoints Development (TED) Award 10/14-09/19 7. R01 HL122658 (Multiple PI: Yaffe and Sidney) NHLBI Determinants of Midlife & Longitudinal Change in Cognitive Function 12/14-11/19 8. W81XWH-12-PHTBI-CENC (PI: Yaffe) Department of Defense/VA Epidemiology Project. Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 02/15-09/19 9. R01 AG048234 (Co-investigator, PI: Kramer) NIA Effects of Chronic Inflammation on Brain Structure and Function 04/15-01/20 10. R01 AG032289 (Co-investigator, PI: Kramer) NIA Biological predictors of brain aging trajectories 09/15-05/20 11. R01 AG052964 (Co-investigator, PI: Cummings) NIA Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins 06/16-05/21 12. RF1 G050745 (Co-investigator, PI: Spira) NIA The ARIC study of midlife sleep and late-life brain amyloid 06/16-05/21 13. UL1 TR991872 (Director of Pilot Grants Program, PI: Grandis) National Center for Advancing Translational Sciences Clinical and Translational Science Institute 07/16-06/21 14. W81XWH-16-1-0507 (PI: Yaffe) Department of Defense Risk and Resiliency for Dementia: Comparison of Male and Female Veterans 08/16-08/19 15. RF1 AG054443 (Multiple PI: Yaffe and Zeki-Al Hazzouri) NIA Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment 05/17-04/21 16. R01 AG054073 (Multiple PI: Yaffe/O’Bryant/Toga) NIA Health Disparities in Alzheimer’s Disease and Mild Cognitive Impairment among Mexican Americans 09/17-05/22 17. R01 AG057508 (Multiple PI: Yaffe/Larson) NIA Systematic Multi-Domain Alzheimer’s Risk Reduction Trial 09/17-05/21 18. R13 AG058415 (Multiple PI: Yaffe/Gill) American Federation for Aging Research Paul B Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting 09/17-05/22 19. R01 AG058537 (Multiple PI: Yaffe/O’Bryant) NIA An Alzheimer’s Blood Test for Primary Care 6/18-5/21 20. P30 AG044281 (Co-Investigator, PI: Covinsky) NIA UCSF Older American Independence Center 07/18-06/23 21. W81XWH-18-1-0692 (Multiple PI: Yaffe/Plassman) Department of Army Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia 9/18-09/21 22. P30 AG062422 (REC Core PI and Data Core Co- Investigator; PI: Miller) NIH New Approaches to Dementia Heterogeneity (Alzheimer’s Disease Research Centers) 04/19-03/24

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists 2) Alzheimer’s Drug Discovery Foundation Connection Between Depressive Symptoms and Dementia:When Best to Intervene? 3)2018-A-006-NET (Co-Investigator, PI: Kramer) Larry L. Hillblom Foundation Hillblom Network for the Prevention of Age-Associated Cognitive Decline

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From San Francisco Veterans Affairs Health Care System (C.B.P., R.C.G., K.Y.), CA; Northern California Institute for Research and Education (C.B.P.), San Francisco; Uniformed Services University of the Health Sciences (K.K.), Rockville; NIH (J.G.), Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; and Departments of Neurology (R.C.G., K.Y.), Psychiatry (K.Y.), and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco.
  1. Correspondence
    Dr. Peltz carrie.peltz{at}ncire.org
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