Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders
A Multinational Prospective Cohort Study
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Article Information
- Received August 4, 2020
- Accepted in final form December 14, 2020
- First Published February 10, 2021.
Article Versions
- Previous version (February 10, 2021 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Davide Martino, MD, PhD,
- Anette Schrag, MD, PhD,
- Zacharias Anastasiou, PhD,
- Alan Apter, MD,
- Noa Benaroya-Milstein, MD, PhD,
- Maura Buttiglione, PhD,
- Francesco Cardona, MD,
- Roberta Creti, PhD,
- Androulla Efstratiou, PhD,
- Tammy Hedderly, MD,
- Isobel Heyman, MBBS, PhD, FRCPsych,
- Chaim Huyser, MD, PhD,
- Marcos Madruga, MD,
- Pablo Mir, MD, PhD,
- Astrid Morer, MD, PhD,
- Nanette Mol Debes, MD, PhD,
- Natalie Moll, MSc,
- Norbert Müller, MD,
- Kirsten Müller-Vahl, MD,
- Alexander Munchau, MD,
- Peter Nagy, MD,
- Kerstin Jessica Plessen, MD, PhD,
- Cesare Porcelli, MD,
- Renata Rizzo, MD, PhD,
- Veit Roessner, MD, PhD,
- Jaana Schnell, MSc,
- Markus Schwarz, MD, PhD,
- Liselotte Skov, MD,
- Tamar Steinberg, MD,
- Zsanett Tarnok, PhD,
- Susanne Walitza, MD, MSc,
- Andrea Dietrich, PhD,
- Pieter J. Hoekstra, MD, PhD and
- on behalf of the EMTICS Collaborative Group
- Davide Martino, MD, PhD,
Scientific advisory board for Sunovion
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Associate Editor of Frontiers in Neurology (Movement Disorders section) Editorial Board member of European Journal of Neurology
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Royalties from Springer Verlag.
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Tourette Association of America (non-profit)
Tourette Association of America (non-profit)
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Ipsen Foundation Canada
Canadian Institutes for Health Research
Parkinson's Association of Alberta; Immunitaet und Seele foundation; Dystonia Medical Research Foundation Canada; Owerko Foundation.
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- Anette Schrag, MD, PhD,
GE Healthcare Roche Biogen Bial
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Movement Disorders NPJ
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Rating Scales in Parkinson's disease. Oxford University Press, 2012
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Medtronic Grunenthal Abbvie Neurotechnology
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GE Healthcare
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International ParkinsonÂs and Movement Disorders Society ParkinsonÂs UK
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Payments from University College London
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- Zacharias Anastasiou, PhD,
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- Alan Apter, MD,
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- Noa Benaroya-Milstein, MD, PhD,
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- Maura Buttiglione, PhD,
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- Francesco Cardona, MD,
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- Roberta Creti, PhD,
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- Androulla Efstratiou, PhD,
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Visiting Professor: Imperial College School of Medicine University of Cyprus Medical School
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- Tammy Hedderly, MD,
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- Isobel Heyman, MBBS, PhD, FRCPsych,
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- Chaim Huyser, MD, PhD,
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Journaal GGZ en recht, SDU uitgevers, ISSN:1574-6801, member of editorial advisory board, 2017-2020.
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- Marcos Madruga, MD,
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- Pablo Mir, MD, PhD,
Dr Mir has served in the Advisory Boards of Abbott, Abbvie, Merz and Zambon.
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Dr Mir has received honorarium for lecturing in meetings organized by Abbott, Allergan, Abbvie. Bial, Britannia, Italfarmaco, Merz, UCB, Teva and Zambon.
Editorial board member of Movement Disorder Clinical Practice, Parkinson Disease, NeurologÃa, Case Reports in Neurological Medicine and BioMed Research International.
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Dr. Mir has received grants from the Spanish Ministry of Science and Innovation [RTC2019-007150-1], the Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (ISCIII-FEDER) [PI14/01823, PI16/01575, PI18/01898, PI19/01576], the ConsejerÃa de EconomÃa, Innovación, Ciencia y Empleo de la Junta de AndalucÃa [CVI-02526, CTS-7685] and the ConsejerÃa de Salud y Bienestar Social de la Junta de AndalucÃa [PI-0471-2013, PE-0210-2018, PI-0459-2018, PE- 0186-2019].
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Dr Mir has received grants from the Sociedad Andaluza de NeurologÃa, the Fundación Alicia Koplowitz and the Fundación Mutua Madrileña.
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- Astrid Morer, MD, PhD,
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- Nanette Mol Debes, MD, PhD,
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- Natalie Moll, MSc,
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- Norbert Müller, MD,
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Foundation
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- Kirsten Müller-Vahl, MD,
(1) non-profit entity:member of the TAA medical advisory boardmember of the scientific advisory board of the German Tourette Association TGDpresident of ESSTSpresident of the IACMpresident of the ACM
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She has received consultant's honoraria from Abide Therapeutics, Allmiral, Boehringer Ingelheim International GmbH, Bionorica Ethics GmbH, CannaMedical Pharma GmbH, Canopy Grouth, Columbia Care, CTC Communications Corp., Eurox Deutschland GmbH, Global Praxis Group Limited, IMC Germany, Lundbeck, Resalo Vertrieb GmbH, Sanity Group, STADAPHARM GmbH, Synendos Therapeutics AG, and Tilray.
Guest editor for Frontiers in Neurology on the research topic ?The neurobiology and genetics of Gilles de la Tourette syndrome: new avenues through large-scale collaborative projects?,Associate editor for ?Cannabis and Cannabinoid Research?, Editorial Board Member for ?Medical Cannabis and Cannabinoids? and ?MDPI-Reports?, and scientific board member for ?Zeitschrift fur Allgemeinmedizin?.
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She has received royalties from Medizinisch Wissenschaftliche Verlagsgesellschaft Berlin, Elsevier, and Kohlhammer
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see 1.andShe is/was a consultant or advisory board member for Abide Therapeutics, The Academy of Medical Cannabis Limited, Alirio, Aphria Deutschland GmbH, CannaMedical Pharma GmbH, Bionorica Ethics GmbH, CannaXan GmbH, Canopy Growth, Columbia Care, CTC Communications Corp., IMC Germany, Leafly Deutschland GmbH, Lundbeck, Nuvelution TS Pharma Inc., Resalo Vertrieb GmbH, Sanity Group, Syqe Medical Ltd., Therapix Biosciences Ltd., Tilray, Wayland Group, and CTC Communications Corporation.
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Abide Therapeutics, Almirall Hermal GmbH, GW pharmaceuticals, Lundbeck, Syneos Health, and Therapix Biosciences Ltd.
EU (FP7-HEALTH-2011 No. 278367, FP7-PEOPLE-2012-ITN No. 316978)German Research Foundation (DFG: GZ MU 1527/3-1)German Ministry of Education and Research (BMBF: 01KG1421)National Institute of Mental Health (NIMH)
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German Tourette Gesellschaft Deutschland e.V.Else-Kroner-Fresenius-Stiftung
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- Alexander Munchau, MD,
German Tourette syndrome Association; Alliance of patients with chronic rare diseases
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Commercial research support: Grants by Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion Honoraria for lectures from Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion, GlaxoSmithKline, Desitin, Teva, Takeda Support from non-profit foundations or societies Possehl-Stiftung, Lübeck; Dystonia Coalition (USA); Tourette Syndrome Association (Germany); European Huntington Disease Network; N.E.MO. Charity supporting the research of paediatric movement disorders
DG Neurologie, Frontiers in Psychiatry, Cognitive Neuroscience
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Royalties for the book Neurogenetics (Oxford University Press)
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Desitin, Merz Pharmaceuticals, Admedicum
Honoraria for lectures: Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion, GlaxoSmithKline, Desitin, Teva, Takeda
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Grants by Pharm Allergan, Ipsen, Merz Pharmaceuticals, Actelion
Deutsche Forschungsgemeinschaft (DFG): projects 1692/3-1, 4-1, SFB 936, and FOR 2698 (project numbers 396914663, 396577296, 396474989), Innovationsausschuss of the Gemeinsamer Bundesausschuss: Translate NAMSE (structural support for the Lübeck Center for Rare Diseases); European Reference Network  Rare Neurological Diseases (ERN  RND)
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Support from Foundations: Possehl-Stiftung (Lübeck, Germany), Margot und Jürgen Wessel Stiftung (Lübeck, Germany), Tourette Syndrome Association (Germany), Interessenverband Tourette Syndrom (Germany), CHDI, Damp- Stiftung;
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Royalties from the publication of the book Neurogenetics (Oxford University Press)
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- Peter Nagy, MD,
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- Kerstin Jessica Plessen, MD, PhD,
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- Cesare Porcelli, MD,
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- Renata Rizzo, MD, PhD,
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Frontiers Pediatric Neurology associate Editors 2019-2020
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- Veit Roessner, MD, PhD,
(1) Shire
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(1) European Child and Adolescent Psychiatry, journal editor, since 2008 (2) Zeitschrift für Kinder- und Jugendpsychiatrie, editorial advisory board member, since 2010 (3) Neuropsychiatrie , editorial advisory board member, since 2012 (4) Scientific Reports, editorial advisory board member, since 2014
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(1) Shire (writing a commentary on German ADHD guidelines)
(1) Otsuka, participating center of a clinical trial on TS medication
(1) Shire (2) Novartis
(1) Kommunaler Spitzenverband Sachsen, PI (2) Sächsisches Staatsministerium für Kultus, PI (3) Sächsisches Staatsministerium für Wissenschaft und Kunst, PI (4) Deutsche Forschungsgemeinschaft, PI (5) Bundesministerium für Bildung und Forschung, PI (6) EU, PI
(1) University of Groningen
(1) Else-Kröner-Fresenius Stiftung (2) Friede-Springer-Stiftung (3) Roland-Ernst- Stiftung
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- Jaana Schnell, MSc,
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- Markus Schwarz, MD, PhD,
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- Liselotte Skov, MD,
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- Tamar Steinberg, MD,
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- Zsanett Tarnok, PhD,
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Frontiers of Human Neuroscience- Atypical Development of Procedural Memory and Related Functions co-editor 2020-2021
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- Susanne Walitza, MD, MSc,
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SW has received in the last 5 years royalties from Thieme Hogrefe (Das sei kein Frosch Programm), Kohlhammer, Springer (Co-Editor: Entwicklungspsychopharmakologie), Beltz .
 Journal of Psychiatric Research: Associate Editor since 2020  Frontiers Research Topic Neurodevelopmental Processes in Health and Disease: Bridging Basic and Clinical Research: Editorial Board Member since 2017  Journal of Neural Transmission: Field Editor for ÂPsychiatry and Preclinical Psychiatric Studies since 2019  ADHD  Attention Deficit and Hyperactivity Disorders: Editorial Board Member until 2019  Frontiers Neuropharmacology (Frontiers in Neuroscience, Frontiers in Neurology
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SW has received in the last 5 years royalties from Thieme Hogrefe (Das sei kein Frosch Programm), Kohlhammer, Springer (Co-Editor: Entwicklungspsychopharmakologie), Beltz .
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Her work was supported in the last 5 years by the Swiss National Science Foundation (SNF), diff. EU FP7s, HSM Hochspezialisierte Medizin of the Kanton Zurich, Switzerland, Bfarm Germany, ZInEP, Hartmann Müller Stiftung, Olga Mayenfisch Outside professional activities and interests are declared under the link of the University of Zurich www.uzh.ch/prof/ssl- dir/interessenbindungen/client/web/
Gertrud Thalmann, Vontobel, Unicentia, Erika Schwarz Fonds, UZH Foundatios
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- Andrea Dietrich, PhD,
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- Pieter J. Hoekstra, MD, PhD and
(1) Shire/Takeda Advisory board meeting
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(1) European Child and Adolescent Psychiatry, editor, 2011- (2) Journal of Neural Transmission, Associate editor, 2012- (3) BMC Pediatrics, associate editor, 2013-
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- on behalf of the EMTICS Collaborative Group
- From the Department of Clinical Neurosciences (D.M.), Cumming School of Medicine & Hotchkiss Brain Institute, University of Calgary, Canada; Department of Clinical Neuroscience (A.S., Z.A.), UCL Institute of Neurology, University College London, UK; Child and Adolescent Psychiatry Department (A.A., N.B.-M., T.S.), Schneider Children's Medical Center of Israel, Petah-Tikva, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Department of Biomedical Sciences and Human Oncology (M.B.), University of Bari “Aldo Moro”; Department of Human Neurosciences (F.C.), University La Sapienza of Rome; Department of Infectious Diseases (R.C.), Istituto Superiore di Sanità, Rome, Italy; WHO Global Collaborating Centre for Reference and Research on Diphtheria and Streptococcal Infections (A.E.), Reference Microbiology, Directorate National Infection Service, Public Health England; Evelina London Children's Hospital GSTT (T.H.), Kings Health Partners AHSC; Psychological Medicine (I.H.), Great Ormond Street Hospital NHS Foundation Trust, London, UK; Department of Child and Adolescent Psychiatry (C.H.), De Bascule, Amsterdam UMC, the Netherlands; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (M.M.), Seville; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica (P.M.), Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville; Department of Child and Adolescent Psychiatry and Psychology (A. Morer), Institute of Neurosciences, Hospital Clínic; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (A. Morer), Barcelona; Centro de Investigación en Red de Salud Mental (CIBERSAM) (A. Morer), Instituto Carlos III, Madrid; Department of Medicine (A. Morer), University of Barcelona, Spain; Child and Adolescent Mental Health Center (N.M.D., K.J.P., L.S.), Mental Health Services, Capital Region of Denmark and University of Copenhagen, Denmark; Institute of Laboratory Medicine (N. Moll, M.S.) and Department of Psychiatry and Psychotherapy (N. Müller, J.S.), University Hospital LMU Munich; Department of Psychiatry, Social Psychiatry and Psychotherapy (K.M.-V.), Hannover Medical School; Institute of Neurogenetics (A. Munchau), University of Lübeck, Germany; Vadaskert Child and Adolescent Psychiatric Hospital (P.N., Z.T.), Budapest, Hungary; Division of Child and Adolescent Psychiatry, Department of Psychiatry (K.J.P.), Lausanne University Hospital, Switzerland; ASL BA, Mental Health Department (C.P.), Adolescence and Childhood Neuropsychiatry Unit, Bari; Child and Adolescent Neurology and Psychiatry, Department of Clinical and Experimental Medicine (R.R.), University of Catania, Italy; Department of Child and Adolescent Psychiatry (V.R.), Medical Faculty Carl Gustav Carus, TU Dresden, Germany; Clinic of Child and Adolescent Psychiatry and Psychotherapy (S.W.), University of Zurich, Switzerland; and Department of Child and Adolescent Psychiatry (A.D., P.J.H.), University of Groningen, University Medical Center Groningen, the Netherlands.
- Correspondence
Dr. Martino davide.martino{at}ucalgary.ca
Article usage
Cited By...
Letters: Rapid online correspondence
- Author Response: Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders: A Multinational Prospective Cohort Study
- Davide Martino, Neurologist, Department of Clinical Neurosciences (D.M.), Cumming School of Medicine & Hotchkiss Brain Institute, Univ. of Calgary, Canada
Submitted April 05, 2021 - Reader Response: Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders: A Multinational Prospective Cohort Study
- Tim Ubhi, Consultant Paediatrician, The Children's e-Hospital
- Kiki Chang, Child, Adolescent & Adult Psychiatrist, Private Practice, Palo Alto, CA
- Rajat Gupta, Consultant Paediatric Neurologist, Birmingham Children's Hospital
- Janet Cunningham, Immunopsychiatrist, Uppsala University
- Alberto Spalice, Paediatric Neurologist, La Sapienza università di Roma
- Peter J Van der Spek, Pathology & Clinical Bioinformatics, Erasmus MC
Submitted March 05, 2021
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