Article Figures & Data
Figures
- Figure 1 Neuropathologic Changes in Cases With Isolated Chronic Traumatic Encephalopathy
(A) Luxol fast blue and hematoxylin-eosin–stained section from superior frontal gyrus used for phospho-tau (p-tau) distribution study. (B and C) Low- and high-power microscopic photos of 1 depth of sulcus perivascular p-tau deposit. High-power photo (C) shows tau-positive tangles in pyramidal-shaped neurons and positivity in astrocytes (smaller cells) and background neuropil around a vessels (*). (D and E) More extensive pathology in the depth of the sulcus and additional subpial tau deposit. (F) Some of the pathologic changes overlap with ARTAG. Scale bar in the top right corner represents 0.5 cm in panel A; 0.1 cm in panel B; 0.03 cm in panels C, E, and F; and 0.05 cm in panel D.
- Figure 2 Neuropathologic Changes in More Advanced Cases of Chronic Traumatic Encephalopathy
Widespread cortical tau deposits in superficial cortical layers and involving both gyri and sulci in a continuous pattern. Some of the superficial cortical pathology can be focal and involve the crown of the gyri with widespread white matter punctate tau deposits in the (B and D) white matter and (C) subventricular areas. Other concomitant pathologies are α-synuclein deposits in the shape of Lewy bodies and neurites as depicted in the (E) cingulate cortex and (F) TAR DNA-binding protein 43 deposits as shown in the dentate gyrus. Scale bar in the top left corner represents 0.1 cm in panels A and B and 0.01 cm in panels C–F.
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