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April 06, 2021; 96 (14) Article

Speech, Language, and Oromotor Skills in Patients With Polymicrogyria

Ruth O. Braden, Jessica O. Boyce, Chloe A. Stutterd, Kate Pope, Himanshu Goel, Richard J. Leventer, Ingrid E. Scheffer, Angela T. Morgan
First published February 15, 2021, DOI: https://doi.org/10.1212/WNL.0000000000011698
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Article Information

vol. 96 no. 14 e1898-e1912
DOI: 
https://doi.org/10.1212/WNL.0000000000011698
PubMed: 
33589534
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 8, 2020
  • Accepted in final form January 6, 2021
  • First Published February 15, 2021.

Article Versions

Copyright & Usage: 
© 2021 American Academy of Neurology

Author Disclosures

    1. Ruth O. Braden, MSpPath,
    2. Jessica O. Boyce, PhD,
    3. Chloe A. Stutterd, BMBS,
    4. Kate Pope, BSc(Nurs),
    5. Himanshu Goel, MD,
    6. Richard J. Leventer, MBBS, PhD*,
    7. Ingrid E. Scheffer, MBBS, PhD* and
    8. Angela T. Morgan, PhD*
  1. Ruth O. Braden, MSpPath,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Jessica O. Boyce, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Chloe A. Stutterd, BMBS,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Health and Medical Research Council of Australia Postgraduate Scholarship

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Kate Pope, BSc(Nurs),
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NHMRC grant; HREC 29077; study coordinator; (2) N/A

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Himanshu Goel, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Richard J. Leventer, MBBS, PhD*,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board - Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NHMRC Project Grant APP1165376. CIA. Neuro-cCMV: determining the contribution of congenital CMV infection to brain malformations and white matter disorders. 2019-2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Ingrid E. Scheffer, MBBS, PhD* and
    8. Scientific Advisory Boards:

    1. (1) GSK - Scientific Advisory Board 2018 (2) Xenon Pharmaceuticals - Scientific Advisory Board 2017 (4) BioMarin - Scientific Advisory Board 2017, 2018, 2019, 2020 (5) UCB - Scientific Advisory Board Chair 2017, 2019, 2020 (6) Eisai - Scientific Advisory Board (7) Rogcon - Scientific Advisory Board (8) Zynerba - Scientific Advisory Board 2020 (9) Chiesi - Scientific Advisory Board 2020 (10) Encoded Therapeutics - Scientific Advisory Board 2020

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) GSK; Travel/Conference expenses. Honoraria, speaker 2017/2018 (2) BioMarin; Honoraria, Travel/Conference expenses 2017/2018/2019/2020/2021 (3) National Research Foundation, Singapore: Travel/conference expenses, honoraria 2018/2019 (4) Athena Diagnostics, Honoraria, Travel/Conference 2018 (5) Eisai: Honoraria, Travel/Conference 2017, 2021 (6) UCB: Travel/Conference

    Editorial Boards:

    1. (1) Neurology, Editorial Board, 2014-present (2) Epilepsy Currents, Editorial Board, 2014-present (3) Epileptic Disorders, Editorial Board, 2006-present (4) Progress in Epileptic Disorders series, Editorial Board, 2005- present

    Patents:

    1. (1) Patent for SCN1A testing held by Bionomics Inc and licensed to various diagnostic companies (WO/2006/133508) (2) Patent for a molecular diagnostic/therapeutic target for benign familial infantile epilepsy (BFIE) [PRRT2] WO/2013/059884 with royalties paid (3) May accrue future revenue on pending patent WO2009/086591: Diagnostic And Therapeutic Methods For EFMR (Epilepsy And Mental Retardation Limited To Females)

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Ovid Therapeutics: 2018 (2) UCB: 2018 (3) Atheneum Partners: 2019 (4) Zynerba Pharmaceuticals: 2020

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. • (1) GW Pharmaceuticals: Participated in Epilepsy Drug Consortium • 2017/2020 and as a trial investigator 2017/2020 • (2) Marinus: trial investigator 2019/2020 • (3) Zynerba Pharmaceuticals: trial investigator 2018/2020 • (4) UCB: trial investigator 2013/2019 • (5) Ovid: trial investigator 2018/2020 • (6) Zogenix: trial investigator 2016/2020 • (7) Ultragenyx: trial investigator 2018-2019 • (8) Eisai: trial investigator • (9) Anavex Life Sciences: trial investigator 2020 • (11) Encoded Therapeutics: trial investigator 2020 • (12) Marinus: trial investigator 2019-2020

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. • (1) National Health and Medical Research Council, Australia: • a) CI,Program Grant 2016-2020 • b) CI, Practitioner Fellowship 2016-2020 • c) CI, Project Grant 2016-2020 • d) CI, Centre for Research Excellence Grant, 2016-2021 • e) CI, Senior Investigator Fellowship 2020-2024 • f) CI, Targeted Call for Research into Preparing Australia for the • Genomics Revolution in Health Care 2016-2020 • (2) National Institute of Health • PI, Centres without Walls funding 'Epi4K' 2016- 2020 • (3) Medical Research Future Fund 2017-2021, 2020- 2024 • (4) Health Research Council New Zealand 2015- 2018, 2020-2022 • (5) Australian Epilepsy Research Fund 2020-2024

    Research Support, Academic Entities:

    1. National Health and Medical Research Council

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Patent for a molecular diagnostic/therapeutic target for benign familial infantile epilepsy (BFIE) [PRRT2] WO/2013/059884 with royalties paid

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Angela T. Morgan, PhD*
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Editorial Board: Developmental Cognitive Neuroscience (March 2013 to current). (2) Editorial Board: Child - Health, Care and Development (May 2013 to current). (3) Editorial Review Board, Frontiers in Psychology (2017 to current) (4) Editorial Review Board, Journal of Speech, Language and Hearing Research (2018 to current) (5) Editorial Board, International Journal of Communication and Language Disorders (2018 to current) (6) Senior Editor, Neurobiology of Language (2019 -)

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Ward, E., & Morgan, A. (2008). 1st Edition. Dysphagia Post Trauma. Plural Publishing.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Redenlab. (2) Deloitte.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1. Redenlab. My husband runs this speech drug trials company.

    Research Support, Government Entities:

    1. Only those already listed in the manuscript.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From Murdoch Children's Research Institute (R.O.B., J.O.B., C.A.S., K.P., R.J.L., I.E.S., A.T.M.); Departments of Audiology and Speech Pathology (R.O.B., J.O.B., A.T.M.) and Paediatrics (C.A.S., R.J.L., I.E.S.), University of Melbourne; The Royal Children's Hospital (C.A.S., K.P., R.J.L., I.E.S., A.T.M.); Victorian Clinical Genetics Service (C.A.S., K.P.), Parkville, Victoria; Hunter Genetics (H.G.), John Hunter Hospital, New Lambton Heights, New South Wales; Austin Health (I.E.S.), Heidelberg, Victoria; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Parkville, Victoria, Australia.
  1. Correspondence
    Prof. Morgan angela.morgan{at}mcri.edu.au
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