Share

April 27, 2021; 96 (17) Article

Natural History of “Pure” Primary Lateral Sclerosis

Anhar Hassan, Shivam Om Mittal, William T. Hu, Keith A. Josephs, Eric J. Sorenson, J. Eric Ahlskog
First published February 26, 2021, DOI: https://doi.org/10.1212/WNL.0000000000011771
Full PDF
Short Form
Citation
Permissions

Make Comment

See Comments

Downloads
472

Share

Article Information

vol. 96 no. 17 e2231-e2238
DOI: 
https://doi.org/10.1212/WNL.0000000000011771
PubMed: 
33637635
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 25, 2020
  • Accepted in final form January 13, 2021
  • First Published February 26, 2021.

Article Versions

Copyright & Usage: 
© 2021 American Academy of Neurology

Author Disclosures

    1. Anhar Hassan, MBBCh, FRACP,
    2. Shivam Om Mittal, MBBS,
    3. William T. Hu, MD, PhD,
    4. Keith A. Josephs, MD, MST, MSc,
    5. Eric J. Sorenson, MD and
    6. J. Eric Ahlskog, PhD, MD
  1. Anhar Hassan, MBBCh, FRACP,
    2. Scientific Advisory Boards:

    1. 1) DSMB for Clinical Trial Readiness for SCA1 and SCA3 (U01) (no compensation)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Parkinsonism and Related Disorders, Editorial Board Member, 2016-. No personal compensation.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Intrabio research support

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Shivam Om Mittal, MBBS,
    3. Scientific Advisory Boards:

    1. (1) Allergan Inc

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. William T. Hu, MD, PhD,
    4. Scientific Advisory Boards:

    1. (1) Apellis Pharmaceuticals

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) University of Pennsylvania, speaker honoraria

    Editorial Boards:

    1. (1) Alzheimer's Dementia: Diagnosis, Assessment & Disease Monitoring, Editorial Board, 2016- present

    Patents:

    1. (1) CSF p/t-Tau ratio as a biomarker for FTLD-TDP. (2) CSF prognostic marker for SMA. (3) Serological tests for SARS-CoV-2 infection.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) AARP, Inc. (2) ViveBio, LLC (3) Fujirebio Diagnostics.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Fujirebio Diagnostics

    Research Support, Government Entities:

    1. (1) NIH/NIA, AG054046, PI, 2016-2021. (2) NIH/NIA, AG054991, PI, 2018-2023. (3) NIH/NIA, AG066203, MPI, 2019-2024.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. (1) CSF p/t-Tau ratio as a biomarker for FTLD-TDP. (2) Serological tests for SARS-CoV-2 infection.

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. (1) Libby Law Firm, treating physician witness, 2020.

  4. Keith A. Josephs, MD, MST, MSc,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Research support from R01-AG037491 (PI), R01-NS89757 (co- PI), R01-DC14942 (PI), R01-DC012519 (Co-I), R01-AG50603 (Co-I), and R21-NS94684 (PI).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Eric J. Sorenson, MD and
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Cytokinetics; Biogen

    Research Support, Government Entities:

    1. (1) ATSDR division of the CDC, (200-2009-32577), ALS consultant for National ALS registry, 5-year grant (2) NINDS, (R01 ES 16348), co-investigator, 5-year grant.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. J. Eric Ahlskog, PhD, MD
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. American Parkinson's Disease Association Fred Springer Award, 2007

    Funding for travel or speaker honoraria:

    1. All honoraria for speaking have been for CME activities. None in recent years.

    Editorial Boards:

    1. Editorial Boards (no compensation): Clinical Neuropharmacology, 1996 to present

    Patents:

    1. NONE

    Publishing Royalties:

    1. Five books: Humana Press: Parkinson's disease and movement disorders (2000) Oxford University Press (4 books): 1. The Parkinson's disease Treatment Book (2005) 2. Parkinson's disease Treatment Guide for Physicians (2009) 3.Dementia with Lewy Bodies & Parkinson's disease Dementia (2014) 4. The New Parkinson's disease Treatment Book (2015)

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I have not had any government support since 2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (A.H., K.A.J., E.J.S., J.E.A.), Mayo Clinic, Rochester, MN; Department of Neurology (S.O.M.), Cleveland Clinic Abu Dhabi, United Arab Emirates; and Department of Neurology (W.T.H.), Emory University, Atlanta, GA.
  1. Correspondence
    Dr. Hassan hassan.anhar{at}mayo.edu
View Full Text

Article usage

Article usage: February 2021 to February 2023

AbstractFullPdfSource
Feb 2021405014Highwire
Mar 2021668040Highwire
Apr 202111639477Highwire
May 202180810866Highwire
Jun 20213954152Highwire
Jul 20212091821Highwire
Aug 2021119914Highwire
Sep 202113575Highwire
Oct 20212071614Highwire
Nov 2021216127Highwire
Dec 2021138149Highwire
Jan 2022140117Highwire
Feb 2022243912Highwire
Mar 2022134710Highwire
Apr 202211476Highwire
May 20228139Highwire
Jun 20223637Highwire
Jul 202294912Highwire
Aug 202270412Highwire
Sep 202278116Highwire
Oct 202281236Highwire
Nov 20227418Highwire
Dec 20226575Highwire
Jan 20235343Highwire
Feb 2023391310Highwire

Cited By...

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top

More Online

CME Course

Related Articles

Topics Discussed

Alert Me

Recommended articles