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January 12, 2021; 96 (2) Article

Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease

Eske Christiane Gertje, View ORCID ProfileDanielle van Westen, Clara Panizo, View ORCID ProfileNiklas Mattsson-Carlgren, View ORCID ProfileOskar Hansson
First published October 12, 2020, DOI: https://doi.org/10.1212/WNL.0000000000011046
Eske Christiane Gertje
From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
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Danielle van Westen
From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
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Clara Panizo
From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
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Niklas Mattsson-Carlgren
From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
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Oskar Hansson
From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
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Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease
Eske Christiane Gertje, Danielle van Westen, Clara Panizo, Niklas Mattsson-Carlgren, Oskar Hansson
Neurology Jan 2021, 96 (2) e193-e202; DOI: 10.1212/WNL.0000000000011046

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Article Information

vol. 96 no. 2 e193-e202
DOI: 
https://doi.org/10.1212/WNL.0000000000011046
PubMed: 
33046608

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 15, 2020
  • Accepted in final form August 28, 2020
  • First Published October 12, 2020.

Article Versions

  • Previous version (October 12, 2020 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2020 American Academy of Neurology

Author Disclosures

    1. Eske Christiane Gertje, MD*,
    2. Danielle van Westen, MD, PhD*,
    3. Clara Panizo, MD,
    4. Niklas Mattsson-Carlgren, MD, PhD† and
    5. Oskar Hansson, MD, PhD†
  1. Eske Christiane Gertje, MD*,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. ST-ALF Funding Region Skåne (2018-2020)

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Danielle van Westen, MD, PhD*,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Clara Panizo, MD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Niklas Mattsson-Carlgren, MD, PhD† and
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. The Wallenberg Center for Molecular Medicine, The Knut and Alice Wallenberg Foundation, The Medical Faculty at Lund University, Region Skåne, the Swedish Research Council, the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson’s disease) at Lund University, the Swedish Alzheimer Foundation, the Swedish Brain Foundation, the Swedish Medical Association, the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, the Bundy Academy, the Skåne University Hospital Foundation.

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Oskar Hansson, MD, PhD†
  10. Scientific Advisory Boards:
    1. Biogen Roche

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. The research support is given in the manuscript.

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. The support is listed in the manuscript.

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Clinical Memory Research Unit (E.C.G., N.M.-C., O.H.), Department of Clinical Sciences Malmö, Lund University; Department of Internal Medicine (E.C.G.), Skåne University Hospital; Diagnostic Radiology (D.v.W., C.P.), Department of Clinical Sciences Lund, Lund University; Imaging and Function (D.v.W., C.P.), Skåne University Health Care; Department of Clinical Sciences Lund (N.M.-C.), Neurology, Lund University, Skåne University Hospital; Wallenberg Center for Molecular Medicine (N.M.-C.), Lund University; andMemory Clinic (O.H.), Skåne University Health Care, Malmö, Sweden.
  1. Correspondence
    Dr. van Westen danielle.van_westen{at}med.lu.se)
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