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January 26, 2021; 96 (4) ArticleOpen Access

Respiratory Trajectories in Type 2 and 3 Spinal Muscular Atrophy in the iSMAC Cohort Study

View ORCID ProfileFederica Trucco, Deborah Ridout, Mariacristina Scoto, View ORCID ProfileGiorgia Coratti, Marion L. Main, Robert Muni Lofra, Anna G. Mayhew, Jacqueline Montes, Marika Pane, Valeria Sansone, Emilio Albamonte, Adele D'Amico, Enrico Bertini, Sonia Messina, Claudio Bruno, Deepak Parasuraman, Anne-Marie Childs, Vasantha Gowda, View ORCID ProfileTracey Willis, Min Ong, Chiara Marini-Bettolo, Darryl C. De Vivo, Basil T. Darras, John Day, Elizabeth A. Kichula, Oscar H. Mayer, Aledie A. Navas Nazario, View ORCID ProfileRichard S. Finkel, Eugenio Mercuri, View ORCID ProfileFrancesco Muntoni, on behalf of the International SMA Consortium (iSMAc)
First published October 16, 2020, DOI: https://doi.org/10.1212/WNL.0000000000011051
Federica Trucco
From the Dubowitz Neuromuscular Centre (F.T., M.S., M.L.M., F.M.) and Population, Policy and Practice Programme (D.R.), UCL GOS Institute of Child Health, London, UK; DINOGMI, University of Genoa (F.T.), IRCCS Istituto G. Gaslini, Italy; NIHR Great Ormond Street Hospital Biomedical Research Centre (D.R., F.M.), Great Ormond Street Institute of Child Health, University College London, and Great Ormond Street Hospital Trust, UK; Paediatric Neurology (G.C., M.P., E.M.), Catholic University; Centro Clinico Nemo (G.C., M.P., E.M.), Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy; John Walton Muscular Dystrophy Research Centre (R.M.L., C.M.-B.), Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK; Departments of Neurology and Pediatrics (J.M., D.C.D.V.) and Departments of Rehabilitation and Regenerative Medicine (J.M.), Columbia University Irving Medical Center, New York, NY; Paediatric Neurology and Centro Clinico Nemo (V.S., E.A.), Milan; Unit of Neuromuscular and Neurodegenerative Disorders (A.D., E.B.), Post-Graduate Bambino Gesù Children's Research Hospital, IRCCS, Rome; Department of Clinical and Experimental Medicine (S.M.), University of Messina Paediatric Neurology and Nemo Sud Clinical Centre; Center of Translational and Experimental Myology (C.B.), IRCCS Istituto Giannina Gaslini, Genova, Italy; University Hospitals Birmingham NHSFT (D.P.); Leeds Children Hospital (A.-M.C.); Evelina Children's Hospital (V.G.), London; The Robert Jones and Agnes Hunt Orthopaedic Hospital (T.W.), Oswestry; Sheffield Children's Hospital (M.O.), UK; Department of Neurology (B.T.D.), Boston Children's Hospital and Harvard Medical School, MA; Stanford University (J.D.), Medical Centre, Palo Alto, CA; Divisions of Pediatric Neurology (E.A.K.), Pulmonology (O.H.M.) and Physical Therapy (A.M.G.), The Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia; and Divisions of Neurology (R.S.F.) and Pulmonary Medicine (A.A.N.N.), Department of Pediatrics, Nemours Children's Hospital, Orlando, FL.
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Deborah Ridout
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Mariacristina Scoto
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Giorgia Coratti
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Marion L. Main
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Robert Muni Lofra
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Anna G. Mayhew
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Jacqueline Montes
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Marika Pane
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Valeria Sansone
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Emilio Albamonte
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Adele D'Amico
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Enrico Bertini
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Sonia Messina
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Claudio Bruno
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Deepak Parasuraman
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Anne-Marie Childs
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Vasantha Gowda
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Tracey Willis
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Min Ong
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Chiara Marini-Bettolo
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Darryl C. De Vivo
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Basil T. Darras
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John Day
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Elizabeth A. Kichula
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Oscar H. Mayer
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Aledie A. Navas Nazario
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Richard S. Finkel
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Eugenio Mercuri
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Francesco Muntoni
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Respiratory Trajectories in Type 2 and 3 Spinal Muscular Atrophy in the iSMAC Cohort Study
Federica Trucco, Deborah Ridout, Mariacristina Scoto, Giorgia Coratti, Marion L. Main, Robert Muni Lofra, Anna G. Mayhew, Jacqueline Montes, Marika Pane, Valeria Sansone, Emilio Albamonte, Adele D'Amico, Enrico Bertini, Sonia Messina, Claudio Bruno, Deepak Parasuraman, Anne-Marie Childs, Vasantha Gowda, Tracey Willis, Min Ong, Chiara Marini-Bettolo, Darryl C. De Vivo, Basil T. Darras, John Day, Elizabeth A. Kichula, Oscar H. Mayer, Aledie A. Navas Nazario, Richard S. Finkel, Eugenio Mercuri, Francesco Muntoni, on behalf of the International SMA Consortium (iSMAc)
Neurology Jan 2021, 96 (4) e587-e599; DOI: 10.1212/WNL.0000000000011051

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Abstract

Objective To describe the respiratory trajectories and their correlation with motor function in an international pediatric cohort of patients with type 2 and nonambulant type 3 spinal muscular atrophy (SMA).

Methods This was an 8-year retrospective observational study of patients in the International SMA Consortium (iSMAc) natural history study. We retrieved anthropometrics, forced vital capacity (FVC) absolute, FVC percent predicted (FVC%P), and noninvasive ventilation (NIV) requirement. Hammersmith Functional Motor Scale (HFMS) and revised Performance of Upper Limb (RULM) scores were correlated with respiratory function. We excluded patients in interventional clinical trials and on nusinersen commercial therapy.

Results There were 437 patients with SMA: 348 with type 2 and 89 with nonambulant type 3. Mean age at first visit was 6.9 (±4.4) and 11.1 (±4) years. In SMA type 2, FVC%P declined by 4.2%/y from 5 to 13 years, followed by a slower decline (1.0%/y). In type 3, FVC%P declined by 6.3%/y between 8 and 13 years, followed by a slower decline (0.9%/y). Thirty-nine percent with SMA type 2% and 9% with type 3 required NIV at a median age 5.0 (1.8–16.6) and 15.1 (13.8–16.3) years. Eighty-four percent with SMA type 2% and 80% with type 3 had scoliosis; 54% and 46% required surgery, which did not significantly affect respiratory decline. FVC%P positively correlated with HFMS and RULM scores in both subtypes.

Conclusions In SMA type 2 and nonambulant type 3, lung function declines differently, with a common leveling after age 13 years. Lung and motor function correlated in both subtypes. Our data further define the milder SMA phenotypes and provide information to benchmark the long-term efficacy of new treatments for SMA.

Glossary

BMI=
body mass index;
CI=
confidence interval;
FVC=
forced vital capacity;
FVC%P=
FVC percent predicted;
HFMS=
Hammersmith Functional Motor Scale;
IQR=
interquartile range;
iSMAc=
International SMA Consortium;
NIV=
noninvasive ventilation;
PEF=
peak expiratory flow;
PEF%P=
PEF percent predicted;
RULM=
revised Performance of Upper Limb;
SMA=
spinal muscular atrophy;
SMN=
survival motor neuron;
ULM=
Upper Limb Module

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • International SMA Consortium (iSMAc) coinvestigators are listed in the appendix 2 at the end of the article.

  • The Article Processing Charge was funded by NIHR.

  • Received May 11, 2020.
  • Accepted in final form September 18, 2020.
  • Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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