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Primary progressive aphasia (PPA) denotes gradual deterioration of language function due to neurodegeneration. Although PPA was initially considered 1 of the 2 main clinical syndromes of frontotemporal dementia pathologies, we now know that about one-third of all PPA cases are due to underlying Alzheimer disease (AD) pathology.1 Over the past quarter-century, the main focus of PPA research has been on phenotyping and differentiating its related language disorders and on the significant clinical and pathologic heterogeneity of the syndrome. A very important but less considered aspect, however, is the remarkable preservation of another aspect of cognition, namely memory, in this condition. This is especially relevant in the case of Alzheimer-related PPA (PPA-AD), given that AD pathology is often considered synonymous with the presence of memory problems.
Footnotes
Go to Neurology.org/Nhttps://n.neurology.org/lookup/doi/10.1212/WNL.0000000000011404 for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
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