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February 23, 2021; 96 (8) ArticleOpen Access

Specialized Outpatient Clinic vs Stroke Unit for TIA and Minor Stroke

A Cohort Study

Sidsel Hastrup, Soren P. Johnsen, Martin Jensen, Paul von Weitzel-Mudersbach, Claus Z. Simonsen, Niels Hjort, Anette T. Møller, Thomas Harbo, Marika S. Poulsen, Helle K. Iversen, Dorte Damgaard, Grethe Andersen
First published January 20, 2021, DOI: https://doi.org/10.1212/WNL.0000000000011453
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Abstract

Objective To evaluate the effects of an outpatient clinic setup for minor stroke/TIA using subsequent admission of patients at high risk of recurrent stroke.

Methods We performed a cohort study of all patients with suspected minor stroke/TIA seen in an outpatient clinic at Aarhus University Hospital, Denmark, between September 2013 and August 2014. Patients with stroke were compared to historic (same hospital) and contemporary (another comparable hospital) matched, hospitalized controls on nonprioritized outcomes: length of stay, readmissions, care quality (10 process–performance measures), and mortality. Patients with TIA were compared to contemporary matched, hospitalized controls. Following complete diagnostic workup, patients with stroke/TIA were classified into low/high risk of recurrent stroke ≤7 days.

Results We analyzed 1,076 consecutive patients, of whom 253 (23.5%) were subsequently admitted to the stroke ward. Stroke/TIA was diagnosed in 215/171 patients, respectively. Fifty-six percent (121/215) of the patients with stroke were subsequently admitted to the stroke ward. Comparison with the historic stroke cohort (n = 191) showed a shorter acute hospital stay for the strokes (median 1 vs 3 days; adjusted length of stay ratio 0.49; 95% confidence interval 0.33–0.71). Thirty-day readmission rate was 3.2% vs 11.6% (adjusted hazard ratio 0.23 [0.09–0.59]), and care quality was higher, with a risk ratio of 1.30 (1.15–1.47). The comparison of stroke and TIAs to contemporary controls showed similar results. Only one patient in the low risk category and not admitted experienced stroke within 7 days (0.6%).

Conclusions An outpatient clinic setup for patients with minor stroke/TIA yields shorter acute hospital stay, lower readmission rates, and better quality than hospitalization in stroke units.

Classification of Evidence This study provides Class III evidence that a neurovascular specialist–driven outpatient clinic for patients with minor stroke/TIA with the ability of subsequent admission is safe and yields shorter acute hospital stay, lower readmission rates, and better quality than hospitalization in stroke units.

Glossary

CDR=
Central Denmark Region;
CI=
confidence interval;
DSR=
Danish Stroke Registry;
DWI=
diffusion-weighted imaging;
HR=
hazard ratio;
ICH=
intracerebral hemorrhage;
LOSR=
length of stay ratio;
NIHSS=
NIH Stroke Scale;
RR=
risk ratio;
SSS=
Scandinavian Stroke Scale

Patients with minor stroke/TIA are at high risk of a recurrent ischemic event,1,2 but landmark studies show a dramatic effect of immediate hospital referral.3,4 It has long been known that patients in an organized inpatient stroke unit fare better than those in a general ward,5,6 and it is feasible and cost-effective to handle most minor strokes and TIAs in specialized acute outpatient clinics.4,7,–,11 However, we do not know how acute outpatient specialist care compares with in-hospital stroke unit care.12,13 It is debated how to most efficiently organize services for patients with minor stroke/TIA12,14,–,16 and use of hospitalization seems widespread.17,18 Hospitalization confers theoretical benefits over urgent outpatient clinic referral including monitoring of the patients and rapid access to revascularization, but these benefits are offset by potential drawbacks of hospitalization together with potential overuse of hospital resources.12,14,19,20 The risk of a recurrent stroke remains the main concern of outpatient treatment and an innovative approach may be a hybrid that combines benefits from both strategies.14

In 2012, an acute outpatient clinic for patients with suspected minor stroke/TIA opened at Aarhus University Hospital, Denmark, following centralization of acute stroke care services.21,22 In the clinic, a specialized neurovascular team performs a complete diagnostic workup and treatment the same day the patient is referred and assesses the risk of patients with stroke/TIA to identify those at high risk of a recurrent stroke and hence eligible for admission to a regular stroke ward.

Methods

Standard Protocol Approvals, Registrations, and Patient Consents

The study was approved by the Danish Data Protection Agency (2012-58-006), the Danish Patient Safety Authority (3-3013-1878/1), and the Danish Clinical Registries. Under Danish law, registry-based studies require no ethics approval or patient consent. The Danish Patient Safety permitted collection of information from the patient records without patients' consent.

Primary Research Question and Classification of Level of Evidence

The primary research question was as follows: Is an outpatient clinic setup for patients with minor stroke/TIA combined with admission of selected high risk patients effective and safe compared to stroke unit admission of all patients with minor stroke/TIA?

This study provides Class III evidence that an outpatient clinic setup for minor stroke/TIA with subsequent admission of patients at high risk of a recurrent stroke yields shorter acute hospital stay, lower readmission rates, and better quality than hospitalization in stroke units.

Outpatient Clinic Setup and Risk Assessment

The outpatient clinic at Aarhus University Hospital, Denmark, is part of 1 of the 2 high-volume designated stroke centers that receive all patients with acute stroke and TIA from the Central Denmark Region (CDR) (1.3 million inhabitants).22 The outpatient clinic is an integrated part of the stroke unit, which is open 7 days a week in the daytime (8 am–6 pm) and staffed by a specialized neurovascular senior doctor, a nurse, and therapists when needed.

A local stroke guideline was developed for all patients with suspected acute stroke and TIA with symptom onset within the past 7 days and 48 hours, respectively, or accumulated neurovascular episodes. According to this guideline, the prehospital service or general practitioners immediately called an experienced neurologist on call 24 hours/7 days to arrange acute evaluation by stroke specialist. All self-reliant patients with suspected acute minor stroke who were not candidates for acute reperfusion or TIA were seen in the outpatient clinic during opening hours. At nighttime, these patients were admitted for immediate evaluation in the stroke unit. The emergency department was bypassed in all cases. Figure 1 shows the details of the patient flow.

Figure 1
Figure 1 Details of the Triage of Patients With Suspected Stroke/TIA (Symptom Onset <7 Days/48 Hours) in the Central Denmark Region in the Study Period

EMS = emergency medical services; GP = general practitioner.

Diagnostic workup in the outpatient clinic included a brain scan (standard MRI), ultrasound of carotid arteries (if indicated, ultrasound, CT angiography, or magnetic resonance angiography of the intracranial vessels), blood samples, ECG, and evaluation of lifestyle factors. If a Holter monitor was indicated, the patient was provided one as an outpatient and could return the equipment by mail. If the patient needed echocardiography, he or she was referred to the Department of Cardiology. All patients in need of outpatient rehabilitation had a full evaluation by a physiotherapist and an occupational therapist before returning home, and had a plan for outpatient rehabilitation by community service. Patients in whom thrombolysis or thrombectomy was indicated were handed over to staff in the stroke unit as the outpatient clinic was part of the acute stroke center and located in the same facilities.

After the outpatient evaluation, we systematically assessed risk in all patients diagnosed with stroke or TIA to distinguish between those at low risk of a recurrent stroke within 7 days who could safely be sent directly home from those at high risk of a recurrent stroke who may need to be admitted to the stroke ward. For risk assessment, we used a tool developed by the neurovascular team. The tool included the ABCD2 score23,–,25 and results of imaging of the brain and precranial or intracranial arteries26,27 together with other risk factors, for example, cardioembolic risk factors. At the neurologist's discretion, other elements like psychosocial issues were taken into account. For patients with stroke, the tool included the NIH Stroke Scale (NIHSS) score28 instead of the ABCD2 score. The risk assessment was a guiding tool only; the final decision to admit the patient to the stroke unit was made at the specialized neurovascular senior doctor's discretion.

If the patient with stroke/TIA was sent home directly from the outpatient clinic, we rang the patient on day 7 to identify any new vascular events.

In patients without a cerebrovascular diagnosis, staff in the outpatient clinic finished the diagnostic workup, performing other relevant tests or procedures, for example, lumbar puncture or other neuroradiologic examinations. The patient was admitted to the general neurologic ward for further investigations only in case of a suspected or confirmed major neurologic disease (e.g., tumor). Furthermore, we assessed patients with non-neurologic disease to determine whether they needed admission at another hospital department or could be sent home to follow up with a general practitioner.

Study Design

This was a cohort study. The effects of the outpatient clinic setup in patients with minor stroke/TIA were investigated by comparing outcomes to those of matched controls.

Study Cohort and Matched Controls

The outpatient clinic cohort included all patients with suspected minor stroke or TIA evaluated in the acute neurovascular outpatient clinic at Aarhus University Hospital, Denmark, between 1 September 2013 and 31 August 2014, including patients who ended up being admitted at the stroke ward or converted to an IV thrombolysis pathway.

Patients with minor strokes were compared to 2 reference populations, including historic and contemporary matched, hospitalized controls, respectively. Patients with TIA were compared to contemporary matched, hospitalized controls only as historic controls were not available in the Danish Stroke Registry (DSR).

Figure 2 shows the details of how we generated the matched historic stroke cohort from the same hospital between May 2011 and April 2012, that is, before the outpatient clinic was established, and the contemporary stroke and TIA cohort from a comparable stroke center at a university hospital in the Capital Region (Glostrup) without an acute outpatient clinic service. Before matching the 2 cohorts, we restricted the patient populations to patients with reliable data on length of acute hospital stay, known vital status, and complete information on matching criteria: age (groups: 0–18, 19–50, 51–65, 66–80, 80+ years), sex, stroke severity (Scandinavian Stroke Scale [SSS] in groups: 0–14, 15–29, 30–44, 45–58), treatment with thrombolysis including door-to-needle time (under or above 1 hour), and subtype of diagnosis (ischemic stroke, ICH, or TIA). The matching was done 1:1, and patients from the reference cohorts could be used more than once.

Figure 2
Figure 2 Details of Generation of the Matched Historic Stroke Cohort and the Matched Contemporary Stroke and TIA Cohorts

Outcomes

The complete study cohort was investigated with regards to the distribution of “neurovascular diagnosis,” “neurologic diagnosis,” and “non-neurologic diagnosis,” and the most common diagnoses within each subgroup were identified. Furthermore, we estimated the rates of patients with subsequent admission at the stroke ward. In patients with ischemic stroke/TIA, we estimated the rates of low risk and high risk according to the risk assessment tool. The rate of recurrent vascular events within 7 days was examined in patients with stroke or TIA discharged directly from the outpatient clinic.

The effects of the outpatient clinic setup were investigated in patients with stroke using the following nonprioritized outcome measures: length of acute and total (including in-hospital rehabilitation) hospital stay, all-cause bed days, hospital readmissions after discharge (0–30 and 31–365 days), mortality (0–30 and 0–365 days), and quality of care (10 individual key process performance measures).

The patients with TIA were evaluated according to the same outcome measures except for readmissions and all-cause bed days as these data were not available and only 4 of the individual key process performance measures were found to be relevant for TIA and were therefore included.

We defined 2 composite measures of process quality of care: the “all or none” measure was defined as the proportion of minor stroke/TIA episodes where all eligible measures were fulfilled for the individual patient, whereas the “opportunity-based” score was defined as the overall proportion of fulfilled relevant performance measures for each patient. The latter score was calculated by dividing the total number of received processes for each patient by the total number of processes for which the patient was considered eligible.

We recorded the number of patients with TIA with acute lesions on MRI (diffusion-weighted imaging [DWI]–positive) or infarction on CT.

Definitions

A suspected acute stroke (or TIA) was defined as acute focal neurologic deficits (or a history of such disease) with no other obvious reasons than a possible cerebrovascular event. Stroke was defined as symptoms of vascular origin lasting 24 hours or longer or leading to death, and included ischemic strokes and intracerebral hemorrhages (ICH). TIA was defined as a transient episode of neurologic symptoms of ischemic origin lasting less than 24 hours, disregarding MRI confirmation, but TIA did not include related syndromes, for example, amaurosis fugax.

Admission length was counted as half rather than whole days when a patient died or went home from the hospital on the day of evaluation. To ensure that the total length of the hospital stay included rehabilitation irrespective of local organizational differences, admissions on the day following the end of the acute stay were calculated as part of the total stay.

All-cause bed days were defined as the total number of days spent in the hospital within the first year, including the total hospital stay of the initial stroke admission. To ensure that outpatient visits were not counted as part of all-cause bed days, only new admissions (acute/nonacute) of ≥24 hours were included.

To be considered a readmission, at least 1 day was required between the day of the termination of the total stay and the next admission date. Only acute admissions ≥24 hours were included; hence, no outpatient visits were considered readmissions. All admissions due to carotid artery surgery were excluded as readmissions because they were considered part of the acute stroke care.

To be classified as being at low risk, patients with TIA would have to have no acute ischemia on MRI (DWI/infarction on CT) or an ABCD2 score ≤3 and patients with stroke an NIHSS score <5. Furthermore, patients with TIA and stroke should have no symptomatic stenosis (≥50%) of the carotid arteries, no symptomatic stenosis (verified or suspected) of the intracranial vessels, no major cardioembolic risk factors, and no other complications for which an inpatient course was needed.

Data Sources

A local registry holds information on diagnosis for all patients (vascular or nonvascular), including imaging and risk assessment, and it includes the mandatory process and outcome indicators collected in the DSR.29,30 This local registry includes results of 7-day follow-up. Local registration was completed on a daily basis by the clinic's neurovascular team. The electronic medical records were searched in case of missing information on risk assessment or vascular events within 7 days.

We obtained data from the DSR (baseline characteristics, length of acute hospital stay, and process performance measures) to characterize strokes and TIA from the study cohort and the matched cohorts. Reporting to the DSR is mandatory for all acute strokes (≥18 years of age) seen at hospitals. Given the Danish tradition for seeing almost all patients with acute stroke symptoms in the hospital, almost all patients with acute stroke in Denmark are registered.31 The completeness of stroke event registration in the DSR exceeds 90%.32

The Danish National Patient Register provided information on subsequent hospitalizations, including transfers from the acute stroke unit to in-hospital rehabilitation and readmissions.33

The Danish Civil Registration System provided information on patients' vital status.34 This system assigns a unique personal identification number to all Danish citizens, and we used this to link information recorded in different databases.

Statistical Analysis

We used a generalized linear model with a log-link and gamma distribution family to compare the length of stay ratios (LOSRs).

For readmissions, we compared hazard ratios (HRs) using multivariable Cox regression encountering the time of a potential readmission or death and analyzed mortality outcomes accordingly. We also calculated adjusted and unadjusted HRs.

We analyzed clinical guideline-recommended process performance measures using binomial regression. Unadjusted risk ratios (RRs) were calculated. We included only cases where the health professionals caring for the individual patient had judged the specific process measure to be relevant.

By using multivariable models, we adjusted for age (continuous variable), living arrangement, previous stroke, diabetes, atrial fibrillation, hypertension, smoking habits, alcohol use, and stroke severity (SSS as a continuous variable). Unknown or missing information on living arrangement, previous stroke, diabetes, atrial fibrillation, hypertension, smoking habits, and alcohol use was encoded by an indicator variable and included in the adjusted analyses. Confidence intervals (CIs) were based on robust standard errors.

We used the Stata 13.0 package (StataCorp LP, College Station, TX) for all analyses.

Data Availability

According to Danish law, it is not possible to provide public access to a dataset that is based on linkage of data from nationwide public registries. Access to Danish registry data can be granted to individual researchers only upon seeking approval from the National Agency for Data Protection. We therefore cannot place the dataset in a public repository. However, pooling of aggregated data is possible and would be of interest to the research group.

Results

The outpatient clinic cohort comprised 1,076 patients (figure 2), of whom 253 (23.5%) were subsequently admitted to the stroke unit. A neurovascular diagnosis was given in 510 of the patients (47.4%). Of these, 215 had a stroke, 171 had TIA, and 124 had another neurovascular diagnosis. Ninety-four (43.7%) of the patients with stroke and 121 (70.8%) of the patients with TIA were sent directly home from the outpatient clinic; of these, 170 (79.1%) were considered low-risk patients (table 1). Of the 690 patients with another neurovascular diagnosis (n = 124) (not stroke or TIA) or a non-neurovascular diagnosis (n = 566), 608 (88.1%) were managed without subsequent admission to the stroke ward.

View this table:
Table 1

Risk Category on all Patients With Ischemic Stroke and TIA From the Outpatient Clinic Cohort and Information on Any Subsequent Admission to the Stroke Ward, n (%)

Of the 124 patients with another neurovascular diagnosis, the 3 most common diagnoses were amaurosis fugax/retinal artery occlusion (n = 65), recrudescence of prior stroke (n = 35), and subdural hemorrhage (n = 6). A large percentage (43.6%) were registered with another neurologic diagnosis (n = 469) and the 3 most common diagnosis among these were disturbances of skin sensation (n = 112), migraine (n = 62), and dizziness (n = 57). A non-neurologic diagnosis was given in only 97 (9%) of the patients from the outpatient clinic cohort and the 3 most common diagnoses were syncope and collapse (n = 21), noncentral disorders of vestibular function (n = 12), and infections (e.g., cystitis, sinusitis, meningitis) (n = 9).

We obtained complete risk assessment score data on all 382 patients with ischemic stroke and TIA from the outpatient clinic cohort. Of the 170 patients at low risk handled as outpatients without subsequent admission to the stroke unit, only one had a recurrent stroke (0.6%) within the first 7 days after the outpatient visit (table 1).

Three patients with ischemic stroke from the study cohort received thrombolysis; all 3 were treated within 1 hour from arrival to the outpatient clinic.

Of the patients with TIA, 33 (19.3%) had an acute lesion on MRI (DWI-positive) or an infarction on CT, whereas this was the case for 187 (88.6%) of the patients with ischemic stroke.

Approximately 90% of the patients with stroke and TIA were available for comparison with the matched reference populations after we had excluded those who were not eligible or matched. Figure 2 shows details of generation of the matched historic stroke cohort and the matched contemporary stroke and TIA cohorts.

The baseline characteristics of the matched stroke and TIA cohorts are shown in table 2. Overall, the groups were well balanced with regard to age (stroke/TIA ≈66–67 years) and stroke severity (stroke ≈55–56 of 58 points on the SSS). The median number of days from symptom onset to admission was the same, with a median of 1 day in the stroke cohorts and 0 days in the TIA cohorts.

View this table:
Table 2

Characteristics of the Patients From the Matched Cohorts: Outpatient Stroke Cohort 1 (OSC1) vs Historic Stroke Cohort (HSC), Outpatient Stroke Cohort 2 (OSC2) vs Contemporary Stroke Cohort (CSC), and Outpatient TIA Cohort (OTC) vs Contemporary TIA Cohort (CTC)

Patients with stroke from the study cohort (n = 191) had a shorter risk-adjusted length of acute hospital stay than the historic stroke cohort (n = 191) (median 1 vs 3 days; adjusted LOSR 0.49 [95% CI 0.33–0.71]) (table 3). Furthermore, the length of total stay including rehabilitation was shorter in the strokes from the study cohort than in the historic cohort (median 1 vs 4 days; adjusted LOSR 0.57 [95% CI 0.36–0.89]) and all-cause bed days within the first year were fewer (median 2 vs 6 days; adjusted LOSR 0.67 [0.46–1.00]). Moreover, in this comparison of strokes from the outpatient clinic cohort with historic controls, readmission rates within the first 30 days after the initial hospital stay were lower (3.2% vs 11.6%; adjusted HR 0.23 [0.09–0.59]), whereas risk-adjusted readmission rates between days 31 and 365 were comparable. Mortality rates at day 30 and day 365 were equal and low (0.0% vs 0.5%; 2.6% vs 5.2%). All or none of 10 process performance measures were higher in the patients with stroke from the outpatient clinic cohort (84.3%) than among patients with stroke in the historic stroke cohort (64.9%) with an RR of 1.30 (1.15–1.47) (table 3).

View this table:
Table 3

Differences in Lengths of Hospital Stay, All-Cause Bed Days, Readmissions, Mortality, and Process Performance Measures in Outpatient Stroke Cohort 1 (OSC1) and the Matched Historic Stroke Cohort (HSC)

The comparison of the patients with stroke from the outpatient clinic cohort (n = 194) with the patients with strokes from the matched contemporary cohort from Glostrup (n = 194) showed almost the same picture, with a shorter median acute hospital stay (1 vs 4 days), fewer readmissions in the first 30 days (3.1 vs 11.3%), comparable mortality rates, and higher all or none of 10 process performance measures (table 4).

View this table:
Table 4

Differences in Lengths of Hospital Stay, All-Cause Bed Days, Readmissions, Mortality, and Process Performance Measures in Outpatient Stroke Cohort 2 (OSC2) and the Matched Contemporary Stroke Cohort (CSC)

Patients with TIA from the outpatient clinic cohort were compared with the matched contemporary TIA cohort from Glostrup. In patients with TIA, the acute and total hospital stays were significantly shorter than in the matched contemporary cohort of patients with TIA. The length of the acute stay was a median of 0.5 days vs 2 days. Mortality rates at day 30 and day 365 were comparable in the 2 TIA cohorts (0.0% vs 0.0%; 2.0% vs 5.9%). All or none of 4 process performance measures were higher in the patients with TIA from the outpatient clinic cohort (96.7%) than in the contemporary TIA patients (87.6%) (table 5).

View this table:
Table 5

Differences in Lengths of Hospital Stay, Mortality, and Process Performance Measures in the Outpatient TIA Cohort (OTC) and the Matched Contemporary TIA Cohort (CTC)

Discussion

This prospective cohort study of patients seen in an outpatient clinic for acute minor stroke and TIA using subsequent admission of high-risk patients shows that these patients have a shorter hospital stay, lower rate of readmissions at 30 days, and higher quality of care than patients in matched historic and contemporary cohorts without a similar outpatient service.

Substantially reducing the length of hospital stay may have the untoward consequence of increasing the overall readmission rate, which is a frequently used measure of quality and safety35,36 of care, although there is some controversy as to how readmissions should be interpreted.37 However, we also observed a lower rate of risk-adjusted readmissions within the first 30 days among patients with stroke in the outpatient clinic cohort. This may be due to overall higher quality of care as evidenced by a decline in the rate of recurrent vascular events and other potential complications.38 Another driver of this reduction could be the lesser risk of a hospital-acquired infection.39 Furthermore, almost half of the patients with stroke in the outpatient clinic cohort (without an inpatient course) were offered a 7-day follow-up by telephone, which was not standard in hospitalized stroke cohorts, and this initiative may have prevented readmissions but also limits direct comparisons. Readmission rates among these outpatients (with or without 7-day follow-up) were low and similar, indicating that the effect on the results may have been inconsiderable.

Another potential concern with the shorter length of stay is recurrent neurovascular events at home, the risk of which is highest during the first days.1,12 To minimize this problem, we aimed to identify and hospitalize patients at high risk of recurrent episodes and hence extended their length of hospital stay.14 To qualify the clinical decision to do so, we developed a risk assessment tool using the ABCD2 score combined with imaging26 and other essential risk factors for recurrent episodes. The ABCD2 score and the later addition of vessel status and brain imaging were originally used to select patients in need of rapid referral to a neurovascular specialist,40 but here we used the tool to qualify the decision of need for hospitalization. This approach seemed acceptable and safe as the overall rate of recurrent vascular episodes in patients who were treated in the outpatient clinic without admission was low (0.9%), only 0.6% of low-risk patients, and the recurrence rates were lower than previously reported.1,41,42

We were not able to calculate a reliable rate of recurrent stroke in the hospitalized patients of the study cohort or in the reference cohorts as new events in the early phase are not registered in the DSR and we did not perform a 7-day follow-up.

The significantly higher fulfillment of process performance measures in patients with minor stroke and TIA from the outpatient clinic cohort within a defined time frame was surprising. Although the exact driver of this remains unknown, we speculate that it may stem from the standardized setup with rapid asses to MRI, ultrasound, and specialist evaluation.

Considering all of the patients with a final diagnosis of stroke and TIA from the entire stroke center at Aarhus University Hospital, approximately 16% of the patients with stroke and 34% of the patients with TIA went to the outpatient clinic in the study period (based on reported patients in 2014 to DSR30), but we were unable to investigate whether, according to the local instruction, more patients were eligible for the outpatient clinic. However, this is likely to have reduced costs per patient as shorter acute hospital stays for patients with stroke reduce hospital costs overall,43 and the outpatient setup is probably also more cost effective.8,15,44 Furthermore, the reduction in the rate of readmissions is likely to contribute further to cost reduction.45 Nevertheless, to make final conclusions on the financial implications, a formal economic evaluation is needed.

Centralization of stroke services resulting in shorter hospital stays is associated with high levels of patient and relative satisfaction and we speculate that this outpatient setup similarly led to increased satisfaction among patients and relatives.46

All patients with suspected acute minor stroke and TIA were referred directly to the outpatient clinic for diagnostic workup from emergency medical services and general practitioners. A considerable number were given a non-neurovascular diagnosis (≈53%). A high rate of minor stroke and TIA misdiagnosis (≈60%) has been documented in nonspecialized settings.47 The result of this is that patients forgo the benefits of timely evaluation and early treatment initiation or are treated unnecessarily. Direct referral saves many people from the debilitating effects of misdiagnosis.47

An MRI scan of the brain was standard in the diagnostic workup and could have contributed to the high rate of non-neurovascular diagnoses, as MRI is more sensitive to acute smaller ischemic lesions than a CT scan48 and helpful in rejecting a stroke/TIA suspicion.

A strength of this study is that it included all patients seen in the outpatient clinic for a period of 1 year and that a high rate of approximately 90% of the patients with stroke or TIA were available for comparison with the matched reference populations.

A limitation of the nonrandomized study design is that it carries a risk of confounding, which might have affected the length of hospital stay, all-cause bed days, rate of readmissions, and mortality, but it is unlikely to have affected the quality of care reflected in key process performance indicators due to very explicit inclusion and exclusion criteria used for these indicators. By matching the cohorts on essential criteria and adjusting data, we minimized the risk of confounding. Furthermore, we used 2 different reference cohorts to examine the effect, which strengthened the design.

The study period began 16 months after opening of the outpatient clinic and hence the comparison with the historic controls may be subject to confounding by an underlying calendar time–related trend of improvements in stroke care. We chose this study period because we aimed to examine the fully implemented setup and therefore deliberately did not include the period immediately after the launch of the reorganization. Furthermore, historic controls for patients with TIA were lacking, as registration of patients with TIA in the DSR was not implemented until mid-2013.

The matched cohort from a contemporary period from another hospital was not exposed to these general time trends in care but was vulnerable to local differences between the hospitals that could potentially affect the results. To minimize this risk, we used patients from a comparable university hospital without an acute outpatient clinic in a region that is sociodemographically and healthwise fairly similar49 and with the same standards of stroke care according to the DSR.30

A randomized controlled experiment where all self-reliant patients suspected of minor stroke and TIA were randomized to either the outpatient clinic or direct hospitalization would have minimized the risk of bias further and would in many ways be the preferred design to study the outpatient setup. This was not an option as the implementation of outpatient clinics was part of the politically decided reorganization of the acute stroke services in the CDR, and a real-world cohort study using matched cohorts therefore became our design choice.50

Overall, the investigated acute outpatient clinic setup for minor stroke and TIA was a hybrid model where specialized neurovascular clinicians diagnosed and assessed the risk of recurrent vascular events to support triage for subsequent admission to the stroke ward. The model was beneficial in terms of reduced length of hospital stay, higher quality of stroke care, and reduced 30-day readmission rates compared to historic and contemporary controls. The triage appears safe with a low rate of recurrent vascular events within the first week after returning home. The study was limited by the nonrandomized design as differences among the study cohorts could affect the comparisons.

Study Funding

This study was supported by the University of Aarhus, Denmark; the Lundbeck Foundation, Denmark; and the Laerdal Foundation, Norway. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; or the decision to submit the manuscript for publication.

Disclosure

S. Hastrup has received a research grant from the University of Aarhus and the Lundbeck Foundation. S.P. Johnsen has received speaker honoraria from Bayer, Bristol-Myers Squibb, Pfizer, and Sanofi; has acted as a consultant for Bayer, Bristol-Myers Squibb, Pfizer, and Sanofi; and has received research grants from Bristol-Myers Squibb and Pfizer. M. Jensen reports no disclosures. P. von Weitzel-Mudersbach has received travel grants from Rapid-Medical, Stryker, and Boehringer-Ingelheim. C.Z. Simonsen has received a research grant from Novo Nordisk Foundation. N. Hjort and A.T. Møller report no disclosures. T. Harbo has received speaker honoraria from CSL Behring. M.S. Poulsen reports no disclosures. H.K. Iversen served on the scientific advisory board for Amgen AB, Bristol-Myers Squibb, Boehringer-Ingelheim, and Bayer. D. Damgaard served on scientific advisory boards for Amgen, Astra Zeneca, Bayer, and Boehringer-Ingelheim and has received speaker honoraria from Amgen, Bayer, Boehringer-Ingelheim, Bristol Myers-Squibb, MSD, and Pfizer. G. Andersen has received speaker honoraria from Boehringer-Ingelheim. Go to Neurology.org/Nhttps://n.neurology.org/lookup/doi/10.1212/WNL.0000000000011453 for full disclosures.

Appendix Authors

Table

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was funded by the University of Aarhus, Denmark; the Lundbeck Foundation, Denmark; and the Laerdal Foundation, Norway.

  • Editorial, page 353

  • Class of Evidence: NPub.org/coe

  • Podcast: NPub.org/jdp9sl

  • Received April 17, 2020.
  • Accepted in final form October 21, 2020.

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