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September 14, 2021; 97 (11) Research Article

Alterations of Brain Metabolites in Adults With HIV

A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies

Sophia Dahmani, Nicholas Kaliss, View ORCID ProfileJohn W. VanMeter, David J. Moore, View ORCID ProfileRonald J. Ellis, View ORCID ProfileXiong Jiang
First published July 12, 2021, DOI: https://doi.org/10.1212/WNL.0000000000012394
Sophia Dahmani
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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Nicholas Kaliss
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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John W. VanMeter
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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  • ORCID record for John W. VanMeter
David J. Moore
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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Ronald J. Ellis
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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Xiong Jiang
From the Department of Neuroscience (S.D., N.K., X.J.) and Department of Neurology (J.W.V.), Georgetown University Medical Center, Washington, DC; Department of Psychiatry (D.J.M., R.J.E.) and Department of Neurosciences (R.J.E.), University of California, San Diego, La Jolla.
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Alterations of Brain Metabolites in Adults With HIV
A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies
Sophia Dahmani, Nicholas Kaliss, John W. VanMeter, David J. Moore, Ronald J. Ellis, Xiong Jiang
Neurology Sep 2021, 97 (11) e1085-e1096; DOI: 10.1212/WNL.0000000000012394

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Abstract

Objective A meta-analysis of proton magnetic resonance spectroscopy studies to investigate alterations in brain metabolites in people with HIV (PWH), the relationship between metabolite alterations and combination antiretroviral therapy (cART), and the relationship between metabolite alterations and cognitive impairment.

Methods The PubMed database was searched for studies published from 1997 to 2020. Twenty-seven studies were identified, which included 1255 PWH and 633 controls. Four metabolites (N-acetyl aspartate [NAA], myo-inositol [mI], choline [Cho], and glutamatergic metabolites [Glx]) from 5 brain regions (basal ganglia [BG], frontal gray and white matter [FGM and FWM], and parietal gray and white matter [PGM and PWM]) were pooled separately using random-effects meta-analysis.

Results During early HIV infection, metabolite alterations were largely limited to the BG, including Cho elevation, a marker of inflammation. cART led to global mI and Cho normalization (i.e., less elevations), but improvement in NAA was negligible. In chronic PWH on cART, there were consistent NAA reductions across brain regions, along with Cho and mI elevations in the FWM and BG, and Glx elevations in the FWM. Cognitive impairment was associated with NAA reduction and to a lesser degree mI elevation.

Conclusions The BG are the primary region affected during early infection. cART is successful in partially controlling neuroinflammation (global mI and Cho normalization). However, neuronal dysfunction (NAA reductions) and neuroinflammation (mI and Cho elevations) persist and contribute to cognitive impairment in chronic PWH. Novel compounds targeting NAA signal pathways, along with better neuroinflammation control, may help to reduce cognitive impairment in PWH.

Glossary

BG=
basal ganglia;
cART=
combination antiretroviral therapy;
Cho=
choline;
FDR=
false discovery rate;
FGM=
frontal gray matter;
FWM=
frontal white matter;
Gln=
Glutamine;
Glu=
glutamate;
Glx=
glutamatergic metabolites;
HAND=
HIV-associated neurocognitive disorder;
mI=
myo-inositol;
MRS=
magnetic resonance spectroscopy;
NAA=
N-acetyl aspartate;
PGM=
parietal gray matter;
PWH=
people with HIV;
PWM=
parietal white matter

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • ↵* These authors are co–first authors.

  • Received December 6, 2020.
  • Accepted in final form May 20, 2021.
  • © 2021 American Academy of Neurology
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