Multicenter Validation of a Deep Learning Detection Algorithm for Focal Cortical Dysplasia
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Article Information
- Received August 29, 2020
- Accepted in final form July 26, 2021
- First Published September 14, 2021.
Article Versions
- Previous version (September 14, 2021 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Ravnoor Singh Gill, PhD-cand,
- Hyo-Min Lee, PhD-cand,
- Benoit Caldairou, PhD,
- Seok-Jun Hong, PhD,
- Carmen Barba, MD,
- Francesco Deleo, MD,
- Ludovico D'Incerti, MD,
- Vanessa Cristina Mendes Coelho, MD,
- Matteo Lenge, PhD,
- Mira Semmelroch, PhD,
- Dewi Victoria Schrader, MD,
- Fabrice Bartolomei, MD,
- Maxime Guye, MD, PhD,
- Andreas Schulze-Bonhage, MD,
- Horst Urbach, MD,
- Kyoo Ho Cho, MD,
- Fernando Cendes, MD, PhD,
- Renzo Guerrini, MD,
- Graeme Jackson, MD,
- R. Edward Hogan, MD,
- Neda Bernasconi, MD, PhD* and
- Andrea Bernasconi, MD*
- Ravnoor Singh Gill, PhD-cand,
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- Hyo-Min Lee, PhD-cand,
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- Benoit Caldairou, PhD,
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- Seok-Jun Hong, PhD,
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- Carmen Barba, MD,
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Associate Editor, Epileptic Disorders
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- Francesco Deleo, MD,
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Salary supports were provided by Paolo Zorzi Association for Neurosciences and educational support was provided by
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- Ludovico D'Incerti, MD,
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EU grant EPICURE contract N° LSHM-CT-2006.0373315.2007- 2010 e Grant from the Italian Ministry of Health (2008- 2010).
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Progetto Fondazioni Paolo Zorzi (2007-2010) Fondazione FBML (2007-2010)
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- Vanessa Cristina Mendes Coelho, MD,
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- Matteo Lenge, PhD,
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- Mira Semmelroch, PhD,
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- Dewi Victoria Schrader, MD,
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- Fabrice Bartolomei, MD,
advisory board Arvelle therapeutic, UCB Pharma, GW Pharma
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UCB pharma Eisai GW Livanova
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- Maxime Guye, MD, PhD,
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(1) Siemens Healthineers, funding for travel to speak at two conferences in 2019, one in 2021
(1) Frontiers in Neurology, editorial board of Epilepsy (2017- )
(1) Virtual epileptic patient technology
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(1) 7T-AMI ANR-11-EQPX-0001, PI, 2014-2021 (2) A*MIDEX-EI-13-07-130115-08.38-7T-AMISTART, Investigator, 2018-2021 (3) HBP SGA3 H2020-EU.1.2.3., 2021-2023, Task Leader
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- Andreas Schulze-Bonhage, MD,
(2) Arvelle, BIAL
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(2) Arelle, BIAL, UCB
Epilepsia, Seizure, Member of the Editorial Board
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(1) BIAL, Epilepsy Foundation, Precisis
NIH, EU, DFG, BMBF
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- Horst Urbach, MD,
Advisory Board Biogen
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Honoraries for lectures from Bayer, Bracco, UCB pharma, Stryker
associate editor Clinical Neuroradiology, editorial advisory board member Neuroradiology
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Shareholder of Veobrain GmbH
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- Kyoo Ho Cho, MD,
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- Fernando Cendes, MD, PhD,
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(1) Travel reimbursement and speaker honoraria for UCB Pharma. (1) speaker honoraria for Eurofarma  Brazil, and Zodiac Pharma  Brazil.
Member of the Editorial Board of the following journals: (1) Neurology: 2010 to present, (2) Epilepsy Research: 2008 to present, (3) Arquivos de Neuropsiquiatria: 2009 to present, (4) Epilepsy and Behavior: 2009 to 2014, (5) Epilepsia: 2012 to present, (6) Frontiers in Neurology: 2010 to present. Associate Editor: Epilepsia 2014 to the present.
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UCB Pharma, United Medical  Brazil, Eurofarma  Brazil, and Zodiac Pharma  Brazil.
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Grant from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil; Grant #2013/07559-3 and Grant from CNPq (Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico), Brazil.
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(1)International League Against Epilepsy, Member of the Diagnostic Methods Commission 2013-present.
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- Renzo Guerrini, MD,
Honoraria for Advisory Board activities and travel related expenses for: (1) Eisai Inc, (2) Novartis, (3) Zogenix, (4) Biomarin, (5) UCB, (6) GW Pharma, (7) Biocodex.
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(1) EISAI: funding for travel. (2) Novartis: funding for travel; (3) UCB: Funding for travel. (3) Biomarin: funding for travel, (4) Novartis: funding for travel, (5) GW funding for travel; (6) Zogenix: funding for traveling and reviewing scientific content of symposia.
(1) Epilepsia: Associate Editor 2006-2013, (2) Progress in Epileptic Disorders, International Advisory Board, 2007- (3) Neuropediatrics, Editorial Board, 2001-2009 (4) Journal of Child Neurology, Editorial Board, 1995-2010, (5) Seizure, Editorial Board 2005-, (6) BMC Medical Genetics,Editorial Board, 2006-, (7) Topics in Epilepsy, Editorial Board, 2009- (8) Journal of Pediatric Epilepsy, Editorial Board, 2011- (9) Epileptic Disorders,Editorial Board, 1999-2012 (10) European Neurological Journal, Editorial Board, 2010- (11) Neurology, Editorial Board, 2013- (12) Journal of Embryology & Developmental Biology, 2016-
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(1) Epilepsy and Movements disorders, Cambridge University Press, 2002, (2) Aicardi's Epilepsy in Children, Lippincott Williams & Wilkins, 2004, (3) Progress in Epileptic Spasms and West Syndrome, John Libbey Eurotext, 2007, (4) Epilepsy and Migraine, John Libbey Eurotext, 2009, (5) The Causes of Epilepsy, Cambridge University Press, 2011. (6) Dravet syndrome, John Libbey Eurotext, 2011. (7) Epilepsy and epileptic seizures, Oxford University Press, 2012. (8) The Causes of Epilepsy 2nd edition, Cambridge University Press, 2019. (9) Epilepsy syndromes in Infancy, Childhood and Adolescence. 6th Edition. John Libbey Eurotext, 2019.
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(1) EU contract number LSH-CT-2006-2011 037315 (EPICURE) FP6 - LIFESCIHEALTH. Subproject Coordinator (2) Tuscany Region. Research Department. Drug treatment and neuroprotection in hypoxic-ischemic brain injury and neonatal infantile seizures. 2010-2013. Project Coordinator. (3) EC PROGRAM Rare disease: use of clinical trial simulation for the choice and optimization of study Design: Era-Net. 2011  2014. Unit Coordinator. (4) EC. Genetics of cortical gyral dysgenesis and pathophysiology of tubulin-related malformations of cortical development. EU PROGRAM: E-RARE2. 2012-2014. Unit Coordinator. (5) EC FP7, 2013-2018. DESIRE: Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy. Grant Agreement 6602531; Project Coordinator, 2013-2018. Italian Ministry of Health and Tuscany Region: An integrated approach to unravel the genetic causes and molecular pathogenesis of epileptogenic focal cortical dysplasia. RF-2013-02355240. 2016-2019. Project Coordinator. DECODEE-Developmental and epileptic encephalopathies: epidemiology, comorbidities, molecular diagnosis, personalized management, and costs analysis. Health call 2018. Tuscany Region. Active 2020-2023. Project Coordinator.
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Pisa Foundation. Grant Title: Development of technology for the diagnostic characterisation and post-chemotherapy- radiotherapy monitoring of paediatric brain tumours using ultra high field MRI. 2013-2016. Project Coordinator. Fondazione Cassa di Risparmio di Firenze. 'Brain Project' 2021-2026. Unit Coordinator.
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- Graeme Jackson, MD,
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ÂPatent # WO/2011/106821. Brain Research Institute Pty Ltd, Fernando Calamante, Jacques-Donald Tournier, Alan Connelly, Graeme Jackson  ÂImage processing system (2013)
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(1) Australian Government Medical Research Future Fund Frontier Health and Medical Research Program Stage One grant (MRFF75908), 2019-2020, (2) Victorian Government Operational Infrastructure Support Grant
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- R. Edward Hogan, MD,
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Editorial board for Acta Neurologica Scandinavia
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Neurelis Inc.
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Principle Investigator for clinical trials funded by Otsuka Pharmaceutical Development and Cerevel Therapeutics
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- Neda Bernasconi, MD, PhD* and
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- Andrea Bernasconi, MD*
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European Neurology, Associate editor, 2020; Neurology, Editorial Board, 2018, 2019, 2020
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- From the Neuroimaging of Epilepsy Laboratory (R.S.G., H.-M.L., B.C., S.-J.H., N.B., A.B.), Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; Pediatric Neurology Unit and Laboratories (C.B., M.L., R.G.), Children's Hospital A. Meyer–University of Florence, Italy; Epilepsy Unit (F.D.) and Neuroradiology (L.D.), Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurology (V.C.M.C., F.C.), University of Campinas, Brazil; The Florey Institute of Neuroscience and Mental Health and The University of Melbourne (M.S., G.J.), Victoria, Australia; Department of Pediatrics (D.V.S.), British Columbia Children's Hospital, Vancouver, Canada; Aix Marseille University (F.B.), INSERM UMR 1106, Institut de Neurosciences des Systèmes; Aix Marseille University (M.G.), CNRS, CRMBM UMR 7339, Marseille, France; Freiburg Epilepsy Center (A.S.-B., H.U.), Universitätsklinikum Freiburg, Germany; Department of Neurology (K.H.C.), Yonsei University College of Medicine, Seoul, Korea; and Department of Neurology (R.E.H.), Washington University School of Medicine, St. Louis, MO.
- Correspondence
Dr. Bernasconi andrea.bernasconi{at}mcgill.ca
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