Share

November 09, 2021; 97 (19) Research Article

Prestroke Disability and Outcome After Thrombectomy for Emergent Anterior Circulation Large Vessel Occlusion Stroke

Adam de Havenon, Alicia Castonguay, Raul Nogueira, Thanh N. Nguyen, Joey English, Sudhakar Reddy Satti, Erol Veznedaroglu, Jeffrey L. Saver, J. Mocco, Pooja Khatri, Eva Mistry, Osama O. Zaidat
First published September 20, 2021, DOI: https://doi.org/10.1212/WNL.0000000000012827
Full PDF
Short Form
Citation
Permissions

Make Comment

See Comments

Downloads
401

Share

Article Information

vol. 97 no. 19 e1914-e1919
DOI: 
https://doi.org/10.1212/WNL.0000000000012827
PubMed: 
34544817
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 20, 2021
  • Accepted in final form August 27, 2021
  • First Published September 20, 2021.

Article Versions

Copyright & Usage: 
© 2021 American Academy of Neurology

Author Disclosures

    1. Adam de Havenon, MD,
    2. Alicia Castonguay, PhD,
    3. Raul Nogueira, MD,
    4. Thanh N. Nguyen, MD,
    5. Joey English, MD,
    6. Sudhakar Reddy Satti, MD,
    7. Erol Veznedaroglu, MD,
    8. Jeffrey L. Saver, MD, MBA,
    9. J. Mocco, MD,
    10. Pooja Khatri, MD,
    11. Eva Mistry, MBBS and
    12. Osama O. Zaidat, MD
  1. Adam de Havenon, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) AMAG Pharmaceuticals, 2) Regeneron Pharmaceuticals

    Research Support, Government Entities:

    1. 1) NIH/NINDS, K23NS105924, Primary Investigator, 2019-2024 Stock/Stock Options, Medical Equipment & Materials: 1) Certus Critical Care

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Alicia Castonguay, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Frontiers of Neurology, Associate Editor, 2021

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Raul Nogueira, MD,
    4. Scientific Advisory Boards:

    1. RGN reports consulting fees for advisory roles with Anaconda, Biogen, Cerenovus, Genentech, Hybernia, Imperative Care, Medtronic, Phenox, Philips, Prolong Pharmaceuticals, Stryker Neurovascular, Shanghai Wallaby, Synchron, and stock options for advisory roles with Astrocyte, Brainomix, Cerebrotech, Ceretrieve, Corindus Vascular Robotics, Vesalio, Viz-AI, RapidPulse and Perfuze.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Interventional Neurology journal - Editor-In-Chief - no compensation

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. RGN is one of the Principal Investigators of the “Endovascular Therapy for Low NIHSS Ischemic Strokes (ENDOLOW)” trial. Funding for this project is provided by Cerenovus to Emory University. Dr. Nogueira serves as a consultant to Cerenovus and receives compensation for these services. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict of interest policies. Stock/Stock Options, Medical Equipment & Materials: RGN is an investor in Viz-AI, Perfuze, Cerebrotech, Reist LLC, Truvic, and Viseon.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. RGN has served as expert testimony to legal proceedings for the United States Attorney’s Office, Muro & Lampe, Inc., Sandberg Phoenix, Lashly & Baer, Rissman, Barrett & Mangan, P.A and Schuering Zimmerman & Doyle, LLP Law Firms.

  4. Thanh N. Nguyen, MD,
    5. Scientific Advisory Boards:

    1. Vesalio, non-profit CREST 2, non-profit

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Frontiers in Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Medtronic

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) Society of Vascular and Interventional Neurology

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Joey English, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. 1) Route 92 Medical, neurovascular catheters and catheter delivery devices

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Stryker Neurovascular Stock/Stock Options, Medical Equipment & Materials: 1) Co-founder and Equity Owner, Route 92 Medical

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Sudhakar Reddy Satti, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consult for: (all commercial) Balt Stryker Neurovascular Cerenovus Microvention Terumo Cordis Penumbra Q'Apel

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Erol Veznedaroglu, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Penumbra - consultant Longevity - consultant Trice - consultant

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Jeffrey L. Saver, MD, MBA,
    9. Scientific Advisory Boards:

    1. Dr. Saver has received contracted hourly payments and travel reimbursement for service on Clinical Trial Steering Committees and Data and Safety Monitoring Boards advising on rigorous clinical trial design and conduct to Medtronic, Stryker, Cerenovus/Johnson+Johnson, BrainsGate, Boehringer Ingelheim (prevention only), NONO Inc, Novo NorDisk, Abbott, and the National Institutes of Health. Dr. Saver has received contracted stock options for services as a scientific consultant advising on rigorous trial design and conduct to Rapid Medical.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Dr Saver served: at JAMA as Associate Editor for Neurology/Neurosurgery throughout the past 2 years; at Stroke as Consulting Editor within the past 2 years, at Journal of Neuroimaging as an Editorial Board Member throughout the past 2 years; at Journal of Stroke and Cerebrovascular Diseases as an Editorial Board Member throughout the past 2 years; and at the journal Circulation within the past 2 years.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Acute stroke care, 35% of effort. Stock/Stock Options, Medical Equipment & Materials: Dr. Saver received stock options in for services as a scientific consultant regarding trial design and conduct to Rapid Medical.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. J. Mocco, MD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Imperative Care (2) Cerebrotech (3) Viseon (4) Endostream (5) Vastrax (6) RIST (7) Synchron (8) Viz.ai (9) Perflow (10) CVAid

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Stryker Neurovascular (2) Microvention (3) Penumbra Stock/Stock Options, Medical Equipment & Materials: (1)Imperative Care (2)Cerebrotech (3)Viseon (4)Endostream (5) Cardinal Consulting (6)RIST (7)Synchron (8)Viz.ai (9)BlinkTBI (10)Serenity (11)Truvic

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Pooja Khatri, MD,
    11. Scientific Advisory Boards:

    1. (1) Diamedica (SAB) (2) Lumosa (company medical representative on DSMB) (3) Basking Biosciences (SAB)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Stroke, Associate Editor, 2020-current

    Patents:

    1. NONE

    Publishing Royalties:

    1. UpToDate, Inc -- ongoing update to Stroke after Cardiac Catheterization article

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Lumosa

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Cerenovus (IIS grant) 2) Bayer (National PI effort)

    Research Support, Government Entities:

    1. 1. NIH/NINDS U24, StrokeNET RCC PI 2. NIH/NINDS U01, StrokeNET NCC MPI 3. NIH/NINDS R01, APRISE MPI 4. NIH/NINDS RF1, APRISE-Dementia-MPI 5. NIH/NINDS, OTA, ACTIV-4A abd ACTIV-4C 6. NIH/NINDS, U01, SATURN 6. NIH/NINDS, U01, ASPIRE 6. NIH/NINDS, U01, FASTEST

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Eva Mistry, MBBS and
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor since July 2021 for Stroke: Vascular and Interventional Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NINDS K23NS113858, Role: PI, 2019-2024

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Osama O. Zaidat, MD
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Consultant and Speaker for Stryker Cerenovous Penumbra Medtronic

    Editorial Boards:

    1. Frontiers in Neurology/Endovascular & Interventional editor Editorial Board Journal of Stroke & Cerebrovascular Diseases

    Patents:

    1. Ischemic stroke device and aneurysm device patents

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant and Speaker for Stryker Cerenovous Penumbra Medtronic

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Research support for investigator initiated research: Stryker Cerenovous Penumbra Medtronic

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (A.d.H.), University of Utah, Salt Lake City; Department of Neurology (A.C.), University of Toledo, OH; Department of Neurology, Neurosurgery, and Radiology (R.N.), Emory University, Atlanta, GA; Department of Neurology, Neurosurgery, and Radiology (T.N.N.), Boston Medical Center, MA; California Pacific Medical Center (J.E.), San Francisco; Department of Neurointerventional Surgery (S.R.S.), Christiana Care Health System, Newark, DE; Department of Neurosurgery (E.V.), Drexel Neurosciences Institute, Philadelphia, PA; Department of Neurology (J.L.S.), University of California, Los Angeles; Department of Neurosurgery (J.M.), Mt. Sinai, New York, NY; Department of Neurology (P.K.), University of Cincinnati, OH; Department of Neurology (E.M.), Vanderbilt Medical Center, Nashville, TN; and Department of Neurology (O.O.Z.), Mercy Health–St. Vincent Medical Center, Toledo, OH.
  1. Correspondence
    Dr. de Havenon adam.dehavenon{at}hsc.utah.edu
View Full Text

Article usage

Article usage: October 2021 to May 2023

AbstractFullPdfSource
Sep 2021790028Highwire
Oct 202144304Highwire
Nov 20211191864306Highwire
Dec 202132912215Highwire
Jan 2022257125Highwire
Feb 2022204126Highwire
Mar 2022260117Highwire
Apr 202216441Highwire
May 20228324Highwire
Jun 20229599Highwire
Jul 202213064Highwire
Aug 20229211Highwire
Sep 202214852Highwire
Oct 202212731Highwire
Nov 202223541Highwire
Dec 20227731Highwire
Jan 20238020Highwire
Feb 20232700Highwire
Mar 20236231Highwire
Apr 20234575Highwire

Cited By...

Letters: Rapid online correspondence

Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

  • No related articles found.

Alert Me