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July 20, 2021; 97 (3) Editorial

New Amyotrophic Lateral Sclerosis Gene Identified

Are Novel Therapies on the Horizon?

Peter Hedera
First published June 16, 2021, DOI: https://doi.org/10.1212/WNL.0000000000012279
Peter Hedera
From the Department of Neurology, University of Louisville, KY.
MD, PhD
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New Amyotrophic Lateral Sclerosis Gene Identified
Are Novel Therapies on the Horizon?
Peter Hedera
Neurology Jul 2021, 97 (3) 105-106; DOI: 10.1212/WNL.0000000000012279

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Proposed pathogenesis of most neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), is complex and typically involves interactions between genetic and environmental factors.1,2 The contribution of genetics in neurodegenerative diseases varies from monogenic causes to more multifaceted susceptibility genetic factors. However, identification of even rare single gene causes in these conditions has been crucial to our evolving understanding of neurodegenerative cascades and may ultimately lead to the development of new therapeutic interventions.3

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the author, if any, are provided at the end of the editorial.

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  • © 2021 American Academy of Neurology
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