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March 22, 2022; 98 (12) Research Article

Cognitive Outcome 1 Year After Mild Traumatic Brain Injury

Results From the TRACK-TBI Study

Andrea L.C. Schneider, J. Russell Huie, W. John Boscardin, Lindsay Nelson, Jason K. Barber, Kristine Yaffe, Ramon Diaz-Arrastia, Adam R. Ferguson, Joel Kramer, Sonia Jain, Nancy Temkin, Esther Yuh, View ORCID ProfileGeoffrey T. Manley, Raquel C. Gardner, on behalf of the TRACK-TBI Investigators
First published February 16, 2022, DOI: https://doi.org/10.1212/WNL.0000000000200041
Andrea L.C. Schneider
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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J. Russell Huie
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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W. John Boscardin
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Lindsay Nelson
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Jason K. Barber
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Kristine Yaffe
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Ramon Diaz-Arrastia
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Adam R. Ferguson
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Joel Kramer
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Sonia Jain
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Nancy Temkin
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Esther Yuh
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Geoffrey T. Manley
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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  • ORCID record for Geoffrey T. Manley
Raquel C. Gardner
From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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From the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
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Cognitive Outcome 1 Year After Mild Traumatic Brain Injury
Results From the TRACK-TBI Study
Andrea L.C. Schneider, J. Russell Huie, W. John Boscardin, Lindsay Nelson, Jason K. Barber, Kristine Yaffe, Ramon Diaz-Arrastia, Adam R. Ferguson, Joel Kramer, Sonia Jain, Nancy Temkin, Esther Yuh, Geoffrey T. Manley, Raquel C. Gardner, on behalf of the TRACK-TBI Investigators
Neurology Mar 2022, 98 (12) e1248-e1261; DOI: 10.1212/WNL.0000000000200041

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Abstract

Background and Objectives The objectives of this study were to develop and establish concurrent validity of a clinically relevant definition of poor cognitive outcome 1 year after mild traumatic brain injury (mTBI), to compare baseline characteristics across cognitive outcome groups, and to determine whether poor 1-year cognitive outcome can be predicted by routinely available baseline clinical variables.

Methods Prospective cohort study included 656 participants ≥17 years of age presenting to level 1 trauma centers within 24 hours of mTBI (Glasgow Coma Scale score 13–15) and 156 demographically similar healthy controls enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) study. Poor 1-year cognitive outcome was defined as cognitive impairment (below the ninth percentile of normative data on ≥2 cognitive tests), cognitive decline (change score [1-year score minus best 2-week or 6-month score] exceeding the 90% reliable change index on ≥2 cognitive tests), or both. Associations of poor 1-year cognitive outcome with 1-year neurobehavioral outcomes were performed to establish concurrent validity. Baseline characteristics were compared across cognitive outcome groups, and backward elimination logistic regression was used to build a prediction model.

Results Mean age of participants with mTBI was 40.2 years; 36.6% were female; 76.6% were White. Poor 1-year cognitive outcome was associated with worse 1-year functional outcome, more neurobehavioral symptoms, greater psychological distress, and lower satisfaction with life (all p < 0.05), establishing concurrent validity. At 1 year, 13.5% of participants with mTBI had a poor cognitive outcome vs 4.5% of controls (p = 0.003). In univariable analyses, poor 1-year cognitive outcome was associated with non-White race, lower education, lower income, lack of health insurance, hyperglycemia, preinjury depression, and greater injury severity (all p < 0.05). The final multivariable prediction model included education, health insurance, preinjury depression, hyperglycemia, and Rotterdam CT score ≥3 and achieved an area under the curve of 0.69 (95% CI 0.62–0.75) for the prediction of a poor 1-year cognitive outcome, with each variable associated with >2-fold increased odds of poor 1-year cognitive outcome.

Discussion Poor 1-year cognitive outcome is common, affecting 13.5% of patients with mTBI vs 4.5% of controls. These results highlight the need for better understanding of mechanisms underlying poor cognitive outcome after mTBI to inform interventions to optimize cognitive recovery.

Glossary

BSI-18-GSI=
18-item Brief Symptom Inventory Global Severity Index;
CDE=
Common Data Element;
ED=
emergency department;
GCS=
Glasgow Coma Scale;
GOAT=
Galveston Orientation and Amnesia Test;
GOSE-TBI=
Glasgow Outcome Scale Extended TBI Version;
mTBI=
mild TBI;
PSI=
Processing Speed Index;
RAVLT=
Rey Auditory Verbal Learning Test;
RCI=
reliable change index;
TBI=
traumatic brain injury;
TMT=
Trail Making Test;
TRACK-TBI=
Transforming Research and Clinical Knowledge in TBI;
WAIS-IV=
Wechsler Adult Intelligence Scale–4th Edition

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • TRACK-TBI Investigators are listed in appendix 2 at the end of the article.

  • Podcast: NPub.org/Podcast9812

  • Received July 2, 2021.
  • Accepted in final form January 3, 2022.
  • © 2022 American Academy of Neurology
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Letters: Rapid online correspondence

  • Author Response: Cognitive Outcome 1 Year After Mild Traumatic Brain Injury
    • Raquel C. Gardner, MD, Behavioral Neurologist and Associate Professor, University of California San Francisco and San Francisco VA Medical Center
    • Andrea L.C. Schneider, MD, PhD, Neurocritical Care Neurologist and Assistant Professor, University of Pennsylvania Perelman School of Medicine
    Submitted May 18, 2022
  • Reader Response: Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study
    • Jack W. Tsao, Neurologist, NYU Langone Grossman School of Medicine
    Submitted May 01, 2022
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