Notable in Neurology This Week
This issue features an article that investigates the use of neurofilament light as a biomarker in the preataxic and ataxic stages of spinocerebellar ataxia type 1; another determines the accuracy and clinical utility of the simplified Edinburgh CT criteria for identifying underlying cerebral amyloid angiopathy in patients with intracerebral hemorrhage. A featured Research Article evaluates the stability of stereo-EEG functional connectivity measures over time and whether they are modified by antiseizure medication.
Research Articles
Association of Reproductive Life Span and Age at Menopause With the Risk of Aneurysmal Subarachnoid Hemorrhage
Using data from postmenopausal participants in the Nurses' Health Study, this study investigated the association of reproductive life span, age at menarche, and age at menopause with the incidence of aneurysmal subarachnoid hemorrhage (aSAH). Shorter reproductive lifespan (≤35 years) and early age at menopause were associated with a twofold higher incidence of aSAH.
Page 829
Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults
Physical activity has been associated with a decreased risk for dementia. This study found that lower insulin and body mass index mediate the association between physical activity and gray matter volume, resulting in greater structural brain integrity, while association with cerebral glucose metabolism appeared to be independent of cardiovascular risk factors.
Page 831
From editorialists Ramanan and Graff-Radford: “...[S]tudies like that from Felisatti et al. add to compelling evidence that regular physical activity over the long term can have positive influences on measures of brain health, particularly in concert with other healthy lifestyle habits.”
Page 825
Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment
This study identified clinicopathologic factors contributing to mild cognitive impairment (MCI) reversion to normal cognition. In analyzing clinical and neuroimaging data from 3 study cohorts, patients with MCI with an experience of reversion to normal cognition were found to have lower dementia risk and better preserved brain structure and glucose metabolism.
Page 832
Historical Neurology
Dr. Betty Clements: Breaking Gender Barriers in the Air Force and Neurology
Dr. Clements was the first female neurology trainee at the Mayo Clinic and a founder of the Barrow Clinic. During World War II, she served with the Women Airforce Service Pilots and later in the American Red Cross. Her career and contributions to the field highlight the important and often unacknowledged role of women in neurology.
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NB: “When Botulinum Toxin Injections Do Not Help Torticollis,” p. 849. To check out other NeuroImages, point your browser to Neurology.org/N. At the end of the issue, check out the Resident & Fellow Section Teaching Video NeuroImage illustrating restless abdomen, a rare variant of restless legs syndrome. This week also includes a Resident & Fellow Clinical Reasoning article titled “A 37-Year-Old Man With Involuntary Movements, Gait Disturbance, and Hyperesthesia.”
- © 2022 American Academy of Neurology
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