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January 25, 2022; 98 (4) Research Article

Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease

A Mendelian Randomization Study

Victoria Taylor-Bateman, Dipender Gill, Marios K. Georgakis, Rainer Malik, Patricia Munroe, Matthew Traylor, on behalf of the International Consortium of Blood Pressure (ICBP)
First published November 29, 2021, DOI: https://doi.org/10.1212/WNL.0000000000013120
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Article Information

vol. 98 no. 4 e343-e351
DOI: 
https://doi.org/10.1212/WNL.0000000000013120
PubMed: 
34845052
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 16, 2021
  • Accepted in final form November 19, 2021
  • First Published November 29, 2021.

Article Versions

Copyright & Usage: 
© 2021 American Academy of Neurology

Author Disclosures

    1. Victoria Taylor-Bateman, MRes,
    2. Dipender Gill, MD, PhD,
    3. Marios K. Georgakis, MD, PhD,
    4. Rainer Malik, PhD,
    5. Patricia Munroe, PhD,
    6. Matthew Traylor, PhD;
    7. on behalf of the International Consortium of Blood Pressure (ICBP)
  1. Victoria Taylor-Bateman, MRes,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Dipender Gill, MD, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. BMC Medicine, Editorial Advisor, 1 year PLOS Medicine, Editorial Advisor, 1 year British Journal of Clinical Pharmacology, Executive Editor, 1 year European Heart Journal Open, Associate Editor, 1 year No financial compensation was received for any of the above.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I have been employed as a Specialist in the Genetics Department of Novo Nordisk Research Centre Oxford since 1 April 2020.

    Consultancies:

    1. 1. Policy Wisdom (commercial entity)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Marios K. Georgakis, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Frontiers in Neurology (since 2021 - Associate Editor in Stroke section)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Onassis Foundation (2) German Academic Exchange Service (DAAD)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Rainer Malik, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Patricia Munroe, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. non-profit - monies for contribution to an educational review article.

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. I was a Editorial Board Member for Physiological Genomics

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Matthew Traylor, PhD;
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Since June 2021 I have been employed as a Specialist in Genetics at Novo Nordisk.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. on behalf of the International Consortium of Blood Pressure (ICBP)
    1. From Clinical Pharmacology (V.T.-B., P.M., M.T.), William Harvey Research Institute, Queen Mary University of London; Department of Epidemiology and Biostatistics (D.P.), School of Public Health, and Department of Medicine (D.G.), Centre for Pharmacology and Therapeutics, Imperial College London; Novo Nordisk Research Centre (D.G., M.T.), Oxford; Clinical Pharmacology and Therapeutics Section (D.G.), Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St. George’s, University of London; Clinical Pharmacology Group (D.G.), Pharmacy and Medicines Directorate, St. George's University Hospitals NHS Foundation Trust, London, UK; Institute for Stroke and Dementia Research (M.G., R.M.), University Hospital of Ludwig-Maximilians-University, Munich, Germany; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre (P.M.), Queen Mary University of London; The Barts Heart Centre and NIHR Barts Biomedical Research Centre–Barts Health NHS Trust (M.T.), William Harvey Research Institute, Queen Mary University London, UK; Center for Genomic Medicine (M.K.G.), Massachusetts General Hospital, Boston; and Program in Medical and Population Genetics (M.K.G.), Broad Institute of Harvard and the Massachusetts Institute of Technology, Boston.
    1. Correspondence
      Dr. Taylor-Bateman v.j.taylor-bateman{at}qmul.ac.uk

    Article usage

    Article usage: November 2021 to October 2023

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