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February 01, 2022; 98 (5) Research Article

Association of the Verbal Component of the GCS With Mortality in Patients With Encephalopathy Who Are Not Undergoing Mechanical Ventilation

Olga Selioutski, Peggy Auinger, Omar K. Siddiqi, View ORCID ProfileBenedict Daniel Michael, View ORCID ProfileClayton Buback, View ORCID ProfileGretchen L. Birbeck
First published November 29, 2021, DOI: https://doi.org/10.1212/WNL.0000000000013127
Olga Selioutski
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Peggy Auinger
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Omar K. Siddiqi
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Benedict Daniel Michael
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Clayton Buback
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Gretchen L. Birbeck
From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
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Association of the Verbal Component of the GCS With Mortality in Patients With Encephalopathy Who Are Not Undergoing Mechanical Ventilation
Olga Selioutski, Peggy Auinger, Omar K. Siddiqi, Benedict Daniel Michael, Clayton Buback, Gretchen L. Birbeck
Neurology Feb 2022, 98 (5) e533-e540; DOI: 10.1212/WNL.0000000000013127

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Article Information

vol. 98 no. 5 e533-e540
DOI: 
https://doi.org/10.1212/WNL.0000000000013127
PubMed: 
34845056

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received April 9, 2021
  • Accepted in final form November 16, 2021
  • First Published November 29, 2021.

Article Versions

  • Previous version (November 29, 2021 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2022 American Academy of Neurology

Author Disclosures

    1. Olga Selioutski, DO,
    2. Peggy Auinger, MS,
    3. Omar K. Siddiqi, MD, MPH,
    4. Benedict Daniel Michael, MRCP, PhD,
    5. Clayton Buback, MD and
    6. Gretchen L. Birbeck, MD, MPH
  1. Olga Selioutski, DO,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. Adjunct faculty at Genesee Community College Polysomnographic Technology Program since 01/15 until 05/2020

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Peggy Auinger, MS,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Omar K. Siddiqi, MD, MPH,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. Fogarty International Clinical Research Fellows Program, R24TW007988, Primary Investigator, 2 years.

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. American Academy of Neurology Clinical Research Training Fellowship.

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Benedict Daniel Michael, MRCP, PhD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. BDM is supported to conduct COVID-19 neuroscience research by the UKRI/MRC (MR/V03605X/1); for additional neurological inflammation research due to viral infection BDM is also supported by grants from the MRC/UKRI (MR/V007181//1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3).

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Clayton Buback, MD and
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Doris Duke Charitable Foundation (Grant ID # 2016174) New York, NY USA

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Gretchen L. Birbeck, MD, MPH
  12. Scientific Advisory Boards:
    1. US NIH Fogarty International Center Advisory Board American Neurological Associate Board of Directors Editorial Board—Neurology; BMC Medicine; Royal Society of Tropical Medicine and Hygiene

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Editorial Board—Neurology; BMC Medicine;

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Spouse serves as medical legal consultant

    Research Support, Government Entities:
    1. NIHR01NS094037 09/15/15-08/30/21 Cohort of HIV-Associated Seizures and Epilepsy in Zambia (CHASE): Scale up and expansion informed by R21 Findings. Role: Co-PI NIHR21MH122238 09/03/20-08/31/22 Collaborative HIV Investigations of Antiretroviral Neuropsychiatric Toxicities in Zambia (CHANTZ) Role: Co-PI NIHR01NS111057 03/15/20-01/31/25 An MRI Ancillary Grant on a Malaria Fever Control RCT Role: Co-PI NIHR01NS102176 09/15/17-09/30/22 Aggressive Antipyretics for fever Control in CNS Malaria: A Randomized Controlled Trial Assessing Antipyretic Efficacy and Parasite Clearance Role: PI R35NS122265 04/01/21-31/03/29 Global Research Endeavors to Advance Treatment of Neurological Disorders in Africa Role: PI

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. My husband has provided expert testimony for various legal firms. A full list is available upon request. None are related to this work in any way.

  1. From the Department of Neurology (O.S., G.L.B.), Epilepsy Division, and Department of Neurology (P.A.), Center for Health and Technology, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology (O.K.S.), Global Neurology Program, and Department of Internal Medicine (O.K.S.), Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA; University of Zambia School of Medicine (O.K.S., G.L.B.), Lusaka; Department of Neurology (B.D.M.), Walton Centre NHS Foundation Trust; NIHR Health Protection Research Unit for Emerging and Zoonotic Infection (B.D.M.); Clinical Infection Microbiology and Immunology (B.D.M.), Institute of Infection, Veterinary, and Zoological Science, University of Liverpool, UK; Department of Neurology (C.B.), University of California San Francisco; and University Teaching Hospitals Children's Hospital (G.L.B.), Lusaka, Zambia.
  1. Correspondence
    Dr. Selioutski olga_selioutski{at}urmc.rochester.edu
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