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March 01, 2022; 98 (9) Editorial

Non-White Participants Matter in White Matter Disease Studies

The Importance of Diversity in Multiple Sclerosis Clinical Trials

Roy Hoshi Hamilton, Olga Ciccarelli
First published January 19, 2022, DOI: https://doi.org/10.1212/WNL.0000000000013224
Roy Hoshi Hamilton
From the Department of Neurology (R.H.H.), University of Pennsylvania, Philadelphia; and Department of Neuro-Inflammation (O.C.), University College London, UK.
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Olga Ciccarelli
From the Department of Neurology (R.H.H.), University of Pennsylvania, Philadelphia; and Department of Neuro-Inflammation (O.C.), University College London, UK.
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Non-White Participants Matter in White Matter Disease Studies
The Importance of Diversity in Multiple Sclerosis Clinical Trials
Roy Hoshi Hamilton, Olga Ciccarelli
Neurology Mar 2022, 98 (9) 345-346; DOI: 10.1212/WNL.0000000000013224

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For many years, multiple sclerosis (MS) was believed to be a disease seen almost solely in White people. However, mounting evidence has made it clear that non-White individuals are equally, if not more frequently and severely, affected by MS than their White counterparts.1,2 Perhaps both a contributor to and consequence of this racial myth is the fact that non-White persons with MS are dramatically underrepresented in MS clinical trials. There is a pressing need to evaluate whether clinical trials are reflective of the diverse population that is affected by MS.

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

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  • © 2022 American Academy of Neurology
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