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September 06, 2022; 99 (10) Research Articles

Association of Ultraprocessed Food Consumption With Risk of Dementia

A Prospective Cohort Study

Huiping Li, Shu Li, Hongxi Yang, Yuan Zhang, Shunming Zhang, Yue Ma, Yabing Hou, Xinyu Zhang, Kaijun Niu, Yan Borné, Yaogang Wang
First published July 27, 2022, DOI: https://doi.org/10.1212/WNL.0000000000200871
Huiping Li
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Shu Li
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Hongxi Yang
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Yuan Zhang
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Shunming Zhang
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Yue Ma
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Yabing Hou
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Xinyu Zhang
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Kaijun Niu
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Yan Borné
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Yaogang Wang
From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
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Association of Ultraprocessed Food Consumption With Risk of Dementia
A Prospective Cohort Study
Huiping Li, Shu Li, Hongxi Yang, Yuan Zhang, Shunming Zhang, Yue Ma, Yabing Hou, Xinyu Zhang, Kaijun Niu, Yan Borné, Yaogang Wang
Neurology Sep 2022, 99 (10) e1056-e1066; DOI: 10.1212/WNL.0000000000200871

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Article Information

vol. 99 no. 10 e1056-e1066
DOI: 
https://doi.org/10.1212/WNL.0000000000200871
PubMed: 
36219796

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 27, 2021
  • Accepted in final form May 5, 2022
  • First Published July 27, 2022.

Article Versions

  • Previous version (July 27, 2022 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2022 American Academy of Neurology

Author Disclosures

    1. Huiping Li, PhD,
    2. Shu Li, PhD,
    3. Hongxi Yang, PhD,
    4. Yuan Zhang, PhD,
    5. Shunming Zhang, PhD,
    6. Yue Ma, PhD,
    7. Yabing Hou, PhD,
    8. Xinyu Zhang, PhD,
    9. Kaijun Niu, PhD,
    10. Yan Borné, PhD and
    11. Yaogang Wang, PhD
  1. Huiping Li, PhD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Shu Li, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Hongxi Yang, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Yuan Zhang, PhD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Shunming Zhang, PhD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Yue Ma, PhD,
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Yabing Hou, PhD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Xinyu Zhang, PhD,
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Kaijun Niu, PhD,
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Yan Borné, PhD and
  20. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Yaogang Wang, PhD
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden.
  1. Correspondence
    Dr. Wang wangyg{at}tmu.edu.cn
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