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The association between migraine and cardiovascular risk is well established but poorly understood.1 Migraine, especially with aura, is an independent risk factor for stroke and ischemic heart disease.1 Although potential migraine-related mechanisms may explain a specific brain vulnerability to ischemia, the pathophysiologic pathways leading to an increased risk of cardiovascular events remain unclear. Because of differences in methodology and definitions, current evidence is conflicting and does not provide unbiased support to the role of traditional risk factors as drivers of cardiovascular risk in patients with migraine.2
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
See page 687
- Received May 22, 2022.
- Accepted in final form June 22, 2022.
- © 2022 American Academy of Neurology
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