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October 18, 2022; 99 (16) Editorial

Common Genetic Variants and Early Onset Stroke

Clues but No Answers

View ORCID ProfileJennifer Juhl Majersik, View ORCID ProfilePaul Lacaze
First published August 31, 2022, DOI: https://doi.org/10.1212/WNL.0000000000200822
Jennifer Juhl Majersik
From the Department of Neurology (J.J.M.), University of Utah, Salt Lake City; and Department of Epidemiology and Preventive Medicine (P.L.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
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  • ORCID record for Jennifer Juhl Majersik
Paul Lacaze
From the Department of Neurology (J.J.M.), University of Utah, Salt Lake City; and Department of Epidemiology and Preventive Medicine (P.L.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
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Common Genetic Variants and Early Onset Stroke
Clues but No Answers
Jennifer Juhl Majersik, Paul Lacaze
Neurology Oct 2022, 99 (16) 683-684; DOI: 10.1212/WNL.0000000000200822

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The incidence of stroke in young adults (early-onset stroke [EOS]) is increasing, and survivors face increased mortality risks and potentially decades living with a disability. Despite this, few studies focus on this population. In approximately 40% of people with EOS, the stroke is cryptogenic,2 and there are scant data from clinical trials to guide the selection of preventative strategies in this population because people with EOS are often excluded from trials. Genetic determinants of EOS have long been suspected, but remain elusive. Monogenic causes (e.g., CADASIL, Fabry disease, and sickle-cell disease) have been implicated in some people with EOS, but the proportion of overall EOS cases with established etiologies remains low.

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 691

  • Received April 4, 2022.
  • Accepted in final form April 21, 2022.
  • © 2022 American Academy of Neurology
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