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November 08, 2022; 99 (19) Editorial

Influenza Vaccination and Ischemic Stroke Prevention

Two for the Price of One

Dixon Yang, View ORCID ProfileMitchell S.V. Elkind
First published September 7, 2022, DOI: https://doi.org/10.1212/WNL.0000000000201265
Dixon Yang
From the Department of Neurology (D.Y., M.S.V.E.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York.
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Mitchell S.V. Elkind
From the Department of Neurology (D.Y., M.S.V.E.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York.
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Influenza Vaccination and Ischemic Stroke Prevention
Two for the Price of One
Dixon Yang, Mitchell S.V. Elkind
Neurology Nov 2022, 99 (19) 827-828; DOI: 10.1212/WNL.0000000000201265

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Seasonal influenza may transiently increase the risk of vascular events, including ischemic stroke (IS).1 Acute systemic inflammation may drive this relationship, possibly through endothelial dysfunction, atherosclerotic plaque instability, and a procoagulant state.2 It therefore stands to reason that influenza vaccination may diminish the associated stroke risk, but the evidence has been mixed. In 2 meta-analyses of observational studies, individuals who received the influenza vaccine were less likely to have a stroke, but the included studies were heterogenous, relatively small, and potentially limited by biases.3,4

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 835

  • Received July 5, 2022.
  • Accepted in final form August 1, 2022.
  • © 2022 American Academy of Neurology
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