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Seasonal influenza may transiently increase the risk of vascular events, including ischemic stroke (IS).1 Acute systemic inflammation may drive this relationship, possibly through endothelial dysfunction, atherosclerotic plaque instability, and a procoagulant state.2 It therefore stands to reason that influenza vaccination may diminish the associated stroke risk, but the evidence has been mixed. In 2 meta-analyses of observational studies, individuals who received the influenza vaccine were less likely to have a stroke, but the included studies were heterogenous, relatively small, and potentially limited by biases.3,4
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
See page 835
- Received July 5, 2022.
- Accepted in final form August 1, 2022.
- © 2022 American Academy of Neurology
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